Daparyl V 10/100 Tablet

DAPARYL V 10/100 TABLET is a medication used to manage Type 2 Diabetes Mellitus in adults. It combines two active ingredients, Dapagliflozin and Vildagliptin, to help control blood sugar levels.

What is DAPARYL V 10/100 TABLET used for?

DAPARYL V 10/100 TABLET is primarily used to manage Type 2 Diabetes Mellitus in adults, especially when diet and exercise alone, or other medications like metformin, are not enough to control blood sugar. This medication helps lower high blood glucose levels, reducing the risk of serious complications associated with long-term uncontrolled diabetes, such as kidney damage, nerve damage, vision loss, and cardiovascular events. It also helps mitigate the risk of cardiovascular death and hospitalization due to heart failure, and assists in treating chronic kidney disease associated with Type 2 diabetes.

How does DAPARYL V 10/100 TABLET work?

DAPARYL V 10/100 TABLET contains two active ingredients: Dapagliflozin and Vildagliptin.

• Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by preventing the kidneys from reabsorbing glucose back into the bloodstream, leading to the excretion of excess glucose through urine. This process helps lower blood sugar levels and may also contribute to weight loss and blood pressure reduction.
• Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of natural substances called incretins, which stimulate insulin release from the pancreas after meals and decrease the amount of sugar produced by the liver, especially when blood sugar is high.

What is the usual dosage of DAPARYL V 10/100 TABLET?

DAPARYL V 10/100 TABLET should be taken exactly as prescribed by your doctor. It can be taken with or without food, usually once or twice daily. It is recommended to take the tablet whole with a glass of water and not to crush, break, or chew it. To maintain consistent blood sugar levels, try to take it at the same time each day. Your doctor will determine the appropriate dosage based on your medical condition and response to treatment. Do not stop taking it without consulting your doctor.

What are the possible side effects of DAPARYL V 10/100 TABLET?

Common side effects may include:

• Vomiting, nausea, abdominal pain, diarrhea
• Headache, dizziness, tremors, fatigue
• Frequent or increased urination
• Hypoglycemia (low blood sugar), especially if taken with other diabetes medications
• Genital yeast infections (vaginal inflammation, balanitis) and urinary tract infections (UTIs)
• Back pain
• Rash

More serious but less common side effects can include:

• Angioedema (swelling of face, throat, or tongue)
• Liver inflammation (yellowing of skin/eyes, nausea, loss of appetite, dark urine)
• Inflammation of the pancreas (severe stomach pain radiating to the back)
• Ketoacidosis
• Fournier's gangrene If you experience any unusual, severe, or persistent side effects, you should consult your doctor immediately.

Is DAPARYL V 10/100 TABLET safe during pregnancy or breastfeeding?

It is generally not recommended to take DAPARYL V 10/100 TABLET during pregnancy or while breastfeeding unless clearly needed and prescribed by a doctor, who will weigh the benefits against the risks. Limited information is available regarding its use in these situations, and moderate side effects have been reported during pregnancy and breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to consult your healthcare provider before starting this medication.

Can DAPARYL V 10/100 TABLET be taken with other medications?

DAPARYL V 10/100 TABLET can interact with certain medications. It is important to inform your doctor about all other medicines, including herbal remedies and supplements, you are currently taking to avoid possible interactions.

• Loop Diuretics (e.g., furosemide, bumetanide): May increase the diuretic effect and risk of dehydration.
• Insulin or Insulin Secretagogues (e.g., glipizide, glimepiride, sulfonylureas): Concurrent use may increase the risk of low blood sugar (hypoglycemia), and a dose adjustment may be needed.
• Mood Stabilizers (e.g., lithium): DAPARYL V may raise lithium levels in the blood, requiring regular monitoring.
• Statins (anti-lipid medications): Exposure to statins like simvastatin may increase.
• ACE inhibitors: May increase the risk of angioedema.
• Medicines used to reduce inflammation (e.g., prednisolone, hydrocortisone) and medicines for underactive thyroid (e.g., levothyroxine) or fits (e.g., phenytoin, phenobarbital) should also be discussed with your doctor.

What precautions should be taken while taking DAPARYL V 10/100 TABLET?

• Medical History: Inform your doctor if you have any liver, kidney, or heart disease, or a history of pancreatitis. This medicine is not recommended for individuals with severe kidney or liver disease, Type 1 diabetes, or metabolic acidosis.
• Dehydration: Drinking plenty of fluids can help prevent dehydration, especially due to increased urination.
• Alcohol: Avoid excessive alcohol consumption as it increases the risk of hypoglycemia (low blood sugar) and lactic acidosis.
• Driving and Operating Machines: DAPARYL V may cause dizziness, so drive or operate machines only if you are alert and feel well.
• Hygiene: Maintaining good hygiene can help prevent genital fungal infections, which are a common side effect.
• Children: This medicine is not recommended for children as its safety and effectiveness have not been established.
• Blood Sugar Monitoring: Regular monitoring of blood sugar levels is essential while on this medication.

What happens if a dose of DAPARYL V 10/100 TABLET is missed?

If you miss a dose of DAPARYL V 10/100 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for the missed one, as this could increase the risk of side effects or cause a rapid drop in blood sugar.

How should DAPARYL V 10/100 TABLET be stored?

Store DAPARYL V 10/100 TABLET in a cool and dry place, away from direct sunlight and moisture. Keep the medication out of the sight and reach of children and pets. Proper storage helps maintain the effectiveness of the medication.