Mesacol Cr 500 Mg Tablet (10 Tab)
Mesalazine (500mg)
Source ID: 249884
Description
MESACOL CR 500 MG TABLET
Mesacol CR 500 mg Tablet is a medication manufactured by Sun Pharmaceutical Industries Ltd., primarily used in the management of inflammatory bowel diseases.
Composition The active ingredient in Mesacol CR 500 mg Tablet is Mesalazine (also known as Mesalamine or 5-Aminosalicylic Acid) in a controlled-release formulation, with each tablet containing 500 mg. Mesalazine is an anti-inflammatory drug belonging to the aminosalicylate class.
Uses Mesacol CR 500 mg Tablet is prescribed for the treatment and management of mild to moderate:
- Ulcerative Colitis: A chronic inflammatory bowel disease that causes inflammation and ulcers in the lining of the large intestine (colon and rectum). It helps reduce symptoms such as diarrhea, rectal bleeding, and stomach pain by reducing inflammation. It may also help prevent further flare-ups.
- Crohn's Disease: Another type of inflammatory bowel disease that can affect any part of the digestive tract. It is used in mild to moderate cases to reduce inflammation and manage flare-ups.
Dosage and Administration Mesacol CR 500 mg Tablet should be taken exactly as prescribed by your doctor.
- Swallow the tablet whole with a glass of water.
- Do not crush, chew, or break the tablet, as it may alter drug release.
- It can generally be taken with or without food; however, some sources suggest taking it one hour before food or two hours after food, or with food for optimal absorption.
- Consistency in taking the medication as recommended is essential to prevent symptoms from returning or worsening. Do not stop the medication suddenly without consulting your doctor.
Side Effects Common side effects may include:
- Diarrhea
- Stomach pain / Abdominal pain
- Headache
- Nausea and Vomiting
- Flatulence (gas)
- Itching and rash
Serious, though less common, side effects include severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis, or an acute intolerance syndrome (characterized by cramping, severe stomach pain, bloody and excessive stools, fever, headache, and rash). If any side effects persist, worsen, or if severe symptoms occur, consult your doctor immediately.
Precautions
- Allergies: Do not take Mesacol CR 500 mg Tablet if you are allergic to Mesalazine, salicylates (such as aspirin, ibuprofen, diclofenac), or sulfasalazine.
- Kidney/Liver Impairment: Use with caution in patients with kidney or liver disease. It is not recommended in cases of severe kidney or liver failure. Your doctor may monitor kidney and liver functions before and during treatment.
- Pregnancy and Breastfeeding: Consult your doctor before using this medicine if you are pregnant, planning a pregnancy, or breastfeeding. It should be used with caution and only if clearly necessary, as Mesalazine can pass into breast milk in small amounts.
- Elderly and Children: Use with caution in elderly patients. It is generally not recommended for children below 6 years of age due to lack of safety and efficacy data.
- Other Medical Conditions: Inform your doctor if you have a history of lung problems (e.g., asthma), heart problems (such as inflammation of the heart), active peptic ulcer, blood disorders, or narrowing/blockage of the stomach/gut.
- Drug Interactions: Inform your doctor about all other medications you are taking, including herbal preparations and supplements. Mesacol CR may interact with sulfasalazine, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen, azathioprine, mercaptopurine, and blood thinners like warfarin. Avoid taking antacids concurrently as it may worsen inflammation.
Storage Store Mesacol CR 500 mg Tablet in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of the reach and sight of children. Store below 30°C (or between 10°C to 25°C).
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Frequently Asked Questions
Here are frequently asked questions about Mesacol CR 500 mg Tablet:
What is Mesacol CR 500 mg Tablet used for?
Mesacol CR 500 mg Tablet is an anti-inflammatory medicine primarily used to treat mild to moderate ulcerative colitis, a chronic inflammatory bowel disease that affects the large intestine. It helps manage symptoms like diarrhea, rectal bleeding, and stomach pain, and can also be used to maintain remission and in some cases, manage Crohn's disease.
How does Mesacol CR 500 mg Tablet work?
Mesacol CR 500 mg Tablet contains Mesalazine (also known as mesalamine), which is an aminosalicylate. It works by locally reducing inflammation in the intestines. It does this by inhibiting the production of certain chemical messengers, such as prostaglandins and leukotrienes, that cause pain and swelling. Mesalazine also acts as an antioxidant and helps regulate immune cells, thereby reducing inflammation and promoting healing in the intestinal lining.
What is the usual dosage for Mesacol CR 500 mg Tablet?
The exact dosage of Mesacol CR 500 mg Tablet is determined by your doctor, depending on your specific condition and response to treatment. It should be taken exactly as prescribed. The tablets should be swallowed whole with a glass of water, and not crushed, chewed, or broken, as this can alter the drug's release. It is generally recommended to take this medicine with food.
What are the possible side effects of Mesacol CR 500 mg Tablet?
Common side effects can include headache, nausea, diarrhea, abdominal pain, rash, flatulence (gas), and dyspepsia (indigestion). Most of these are usually mild and temporary. More serious, but rare, side effects can include severe allergic reactions (e.g., swelling of the face, tongue, or throat), worsening of colitis symptoms, or kidney or liver problems. If you experience any severe or persistent side effects, you should consult your doctor.
Is Mesacol CR 500 mg Tablet safe during pregnancy or breastfeeding?
Pregnancy: Mesacol CR 500 mg Tablet is generally not recommended during pregnancy unless the potential benefits outweigh the risks. It is crucial to discuss this with your doctor if you are pregnant or planning to conceive. Breastfeeding: Small amounts of mesalazine pass into breast milk. Caution is advised, and you should consult your doctor before using this medicine while breastfeeding. Your doctor will weigh the benefits and risks, and if prescribed, monitor the infant for symptoms like diarrhea.
Can Mesacol CR 500 mg Tablet be taken with other medications?
Mesacol CR 500 mg Tablet can interact with certain other medications. For example, taking it with azathioprine or 6-mercaptopurine may increase the risk of blood disorders. It can also increase the effect of coumarin-type anticoagulants like warfarin. Antacids or adsorbents might reduce the absorption of mesalazine. Always inform your doctor about all prescription, over-the-counter, and herbal medications you are taking to avoid potential interactions.
What precautions should be taken while using Mesacol CR 500 mg Tablet?
Before taking Mesacol CR 500 mg Tablet, inform your doctor if you have any kidney or liver problems, lung diseases (like asthma), heart conditions, stomach blockages, or known allergies to mesalazine, salicylates (like aspirin), or sulfasalazine. Your doctor may monitor your kidney, liver, blood, and lung functions periodically during treatment. It is also advised to drink plenty of water to help prevent kidney stone formation. Do not stop taking the medicine abruptly without consulting your doctor. It is not recommended for children under 6 years of age.
What happens if a dose of Mesacol CR 500 mg Tablet is missed?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Consistency is important for the effectiveness of the medication.
How should Mesacol CR 500 mg Tablet be stored?
Mesacol CR 500 mg Tablet should be stored in a cool, dry place, typically below 30°C, and protected from direct sunlight, heat, and moisture. Keep the medicine in its original packaging until use and ensure it is kept out of the reach of children. Always check the expiry date and use the medicine before that point.