Ondero Met 2.5mg/500mg Tablet

Ondero Met 2.5mg/500mg Tablet, manufactured by Lupin Ltd., is a combination medication containing Linagliptin (2.5mg) and Metformin (500mg). It is primarily prescribed for adults to manage Type 2 Diabetes Mellitus.

What is Ondero Met 2.5mg/500mg Tablet used for?

Ondero Met 2.5mg/500mg Tablet is used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is often prescribed when diet, exercise, and a single medication (like Metformin alone) are not sufficient to achieve adequate blood sugar control. By improving glycemic control, it helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and the risk of heart attack or stroke.

How does Ondero Met 2.5mg/500mg Tablet work?

This medicine combines two active ingredients: Linagliptin and Metformin, which work together to lower blood sugar.

• Linagliptin (a DPP-4 inhibitor) increases the production of insulin from the pancreas and reduces the hormones that raise blood sugar levels, specifically after meals. It helps the body produce more insulin only when required.
• Metformin (a biguanide) works by lowering glucose production in the liver, delaying the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin. Together, they help control both fasting and post-meal blood sugar levels.

What is the usual dosage?

The typical dosage is usually one tablet once or twice daily, taken with meals to minimize gastrointestinal side effects. Your doctor will determine the appropriate dose based on your condition, blood sugar levels, and other medications you are taking. It is important to take it at the same time each day for the best results and not to crush, chew, or break the tablet; swallow it whole with water.

What are the possible side effects?

Common side effects can include hypoglycemia (low blood glucose levels), dizziness, sweating, hunger pangs, dry mouth, skin changes, altered taste, nausea, diarrhea, stomach pain, headache, and upper respiratory symptoms. A rare but serious side effect associated with Metformin is lactic acidosis, which can be fatal if not treated. Symptoms include unusual muscle pain, trouble breathing, stomach pain, vomiting, and feeling very weak or tired. Long-term use of Metformin can also lead to Vitamin B12 deficiency.

Is it safe during pregnancy or breastfeeding?

Ondero Met 2.5mg/500mg Tablet is generally not recommended during pregnancy as there is definite evidence of risk to the developing baby. It is also considered unsafe during breastfeeding as components of the medicine are known to pass into breast milk and may cause toxicity to the baby. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can it be taken with other medications?

Ondero Met 2.5mg/500mg Tablet can interact with certain other medicines.

• Other antidiabetic medications (e.g., sulfonylureas and insulin): Concurrent use can increase the risk of hypoglycemia (low blood sugar).
• Diuretics (e.g., furosemide): May increase the risk of lactic acidosis due to dehydration.
• Corticosteroids, thyroxine, water pills, anti-tuberculosis medicines, anti-HIV medicines, anti-hypertensive drugs, anti-epileptic drugs, antidepressants, painkillers, antibiotics, and oral contraceptives can also interact, potentially altering the medicine's potency or increasing side effects. Always inform your doctor about all medicines, over-the-counter drugs, and herbal preparations you are taking.

What precautions should be taken?

• Kidney and Liver Function: Inform your doctor if you have kidney or liver problems, as impaired function can increase the risk of side effects, including lactic acidosis. Regular monitoring of kidney function is advised.
• Alcohol Consumption: Avoid excessive alcohol intake, as it can lower blood sugar and significantly increase the risk of lactic acidosis.
• Pancreatitis: Inform your doctor if you have a history of pancreatitis, as linagliptin may cause inflammation of the pancreas.
• Surgery: Your doctor may decrease your dosage or stop the medication before surgery to reduce the risk of lactic acidosis.
• Type 1 Diabetes and Diabetic Ketoacidosis: This medicine is not for treating Type 1 diabetes or diabetic ketoacidosis.
• Hypoglycemia: Be aware of the symptoms of low blood sugar and carry a fast-acting source of sugar (e.g., fruit juice, hard candy) for immediate relief. Don't skip meals.
• Vitamin B12 Deficiency: Long-term use may cause Vitamin B12 deficiency; your doctor may advise monitoring and supplementation.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can increase the risk of side effects.

How should it be stored?

Store Ondero Met 2.5mg/500mg Tablet in a cool and dry place, below 30°C, away from direct sunlight and heat. Keep it out of sight and reach of children.