Nindanib 150mg

Nindanib 150mg, manufactured by Glenmark Pharmaceuticals Ltd, contains the active ingredient Nintedanib. It is a medication primarily used to treat certain chronic lung diseases and some types of cancer.

What is Nindanib 150mg used for?

Nindanib 150mg is used to treat adults with idiopathic pulmonary fibrosis (IPF), which is a chronic lung disease causing scarring of the lungs. It is also prescribed for other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, and to slow the decline in lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Additionally, it is used in the treatment of certain types of non-small cell lung cancer (NSCLC).

How does Nindanib 150mg work?

Nindanib 150mg is a type of medicine called a tyrosine kinase inhibitor (TKI). It works by blocking several growth factor receptors in the body, such as platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR), and vascular endothelial growth factor receptor (VEGFR). By inhibiting these receptors, Nindanib helps to reduce the proliferation and migration of fibroblasts, which are cells involved in the formation of scar tissue in the lungs. This action helps to slow down the scarring process in lung diseases and can inhibit the growth and spread of certain cancer cells.

What is the usual dosage for Nindanib 150mg?

The usual recommended dosage for Nindanib 150mg is one 150 mg capsule taken twice daily, approximately 12 hours apart. It should be swallowed whole with liquid and taken with food. Do not chew, crush, or open the capsules. Your doctor may adjust the dose or temporarily interrupt treatment if you experience side effects. The maximum daily dose is 300 mg.

What are the possible side effects of Nindanib 150mg?

Common side effects include diarrhea, nausea, vomiting, abdominal pain, decreased appetite, headache, and weight loss. More serious, though less common, side effects can include liver problems (e.g., yellowing of skin/eyes, dark urine, upper right abdominal pain), bleeding problems, high blood pressure, and gastrointestinal perforation. It is important to inform your doctor if you experience any persistent or severe side effects.

Is Nindanib 150mg safe during pregnancy or breastfeeding?

Nindanib 150mg is not recommended during pregnancy as it can cause birth defects or be harmful to an unborn baby. Women who are able to become pregnant must use highly effective birth control before starting, during, and for at least 3 months after treatment. It is also not recommended during breastfeeding, as it is unknown if the medication passes into breast milk and could potentially harm a nursing infant.

Can Nindanib 150mg be taken with other medications?

Nindanib 150mg can interact with other medications. It is important to inform your doctor about all prescription, over-the-counter, vitamin, and herbal supplements you are taking. Medications that affect certain enzymes (P-gp and CYP3A4 inducers/inhibitors), such as ketoconazole, erythromycin, rifampicin, carbamazepine, phenytoin, and St. John's wort, can alter the levels of Nindanib in your body. Taking Nindanib with blood-thinning medications may increase the risk of bleeding.

What precautions should be taken while taking Nindanib 150mg?

Before starting Nindanib, tell your doctor if you have liver problems, heart problems, bleeding problems, kidney issues, a history of blood clots, or if you have had recent surgery in your stomach area. Liver function tests will be performed before and regularly during treatment. Women of childbearing potential must use effective contraception. Smoking should be avoided as it may reduce the medicine's effectiveness. Also, avoid consuming grape juice while on this medication.

What happens if a dose of Nindanib 150mg is missed?

If you miss a dose of Nindanib 150mg, skip the missed dose and take your next dose at your regularly scheduled time. Do not take an extra dose or a double dose to make up for the missed one.

How should Nindanib 150mg be stored?

Nindanib 150mg capsules should be stored in a cool and dry place, typically below 25°C or 30°C. Protect the medication from direct sunlight and moisture. Keep it out of the sight and reach of children and pets.