Brivgard 50

BRIVGARD 50, manufactured by Lupin Ltd., contains Brivaracetam, an antiepileptic medication used to manage partial-onset seizures in individuals with epilepsy.

Here are some frequently asked questions about BRIVGARD 50:

What is BRIVGARD 50 used for?

BRIVGARD 50 is used to treat partial-onset seizures in adults and children aged one month and older who have epilepsy. It can be used alone or in combination with other antiepileptic drugs.

How does BRIVGARD 50 work?

BRIVGARD (Brivaracetam) is believed to work by binding with high affinity to synaptic vesicle protein 2A (SV2A) in the brain. This action helps to suppress abnormal electrical activity in the nerve cells, thereby reducing the frequency and severity of seizures.

What is the usual dosage of BRIVGARD 50?

For adults aged 16 years and older, the typical starting dose is 50 milligrams (mg) twice a day. Your doctor may adjust the dose based on your response and tolerability, with doses usually not exceeding 100 mg twice a day (200 mg/day). For children aged 1 month to less than 16 years, the dose is determined by body weight and must be prescribed by a doctor. The tablets should be swallowed whole with liquid and can be taken with or without food.

What are the possible side effects of BRIVGARD 50?

Common side effects of BRIVGARD 50 include sleepiness, dizziness, fatigue, nausea, and vomiting. Some individuals may also experience irritability, anxiety, mood changes, and headaches. Serious side effects can include suicidal thoughts or behaviors, aggression, agitation, and severe allergic reactions (e.g., swelling of the face, lips, tongue, or throat, difficulty breathing). It's crucial to report any unusual changes in mood or behavior to your doctor immediately.

Is BRIVGARD 50 safe during pregnancy or breastfeeding?

Pregnancy: BRIVGARD 50 (Brivaracetam) is generally not recommended for use during pregnancy unless considered necessary by your doctor, as animal studies have shown potential harm to the developing fetus. There is limited data on its use in pregnant women, and caution is advised. If you become pregnant while taking this medicine, inform your healthcare provider immediately.

Breastfeeding: BRIVGARD 50 is generally not recommended during breastfeeding because it can pass into breast milk. It is best to consult your doctor to discuss the potential risks and benefits if you are breastfeeding or plan to breastfeed.

Can BRIVGARD 50 be taken with other medications?

BRIVGARD 50 can interact with certain other medications. For example, its levels may decrease when taken with other antiepileptic medicines like carbamazepine and phenytoin, potentially reducing its effectiveness. Antibiotics like rifampin can also reduce the levels of brivaracetam. Co-administration with Central Nervous System (CNS) depressants such as opioids, antidepressants, or anti-anxiety medicines can increase drowsiness and sedation. Always inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken with BRIVGARD 50?

It is very important that your doctor regularly monitors your progress, especially during the initial months of treatment, to adjust the dose and check for any unwanted effects. Do not stop taking BRIVGARD 50 abruptly, as this can lead to an increase in seizure frequency or even status epilepticus (seizures that won't stop). Since it can cause drowsiness, dizziness, or problems with coordination, avoid driving or operating heavy machinery until you know how the medicine affects you. Alcohol consumption should also be avoided as it can enhance these side effects. Inform your doctor if you have liver or kidney problems, depression, or a history of suicidal thoughts, as these conditions may require dose adjustments or careful monitoring.

What happens if a dose of BRIVGARD 50 is missed?

If you miss a dose of BRIVGARD 50, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double doses to make up for a missed one.

How should BRIVGARD 50 be stored?

Store BRIVGARD 50 tablets in a closed container at room temperature, away from heat, moisture, and direct light. Keep it out of the reach of children. If you are using the oral solution, discard any unused portion 5 months after first opening the bottle. Do not keep outdated medicine.