Diabetrol Sr

DIABETROL SR

DIABETROL SR, manufactured by Abbott, is a combination medication used for the management of type 2 diabetes mellitus in adults.

• Composition:

  • DIABETROL SR contains two active ingredients: Glibenclamide (typically 5 mg) and Metformin (typically 500 mg).
  • Glibenclamide, a sulfonylurea, stimulates insulin secretion from the pancreas. Metformin, a biguanide, primarily reduces glucose production in the liver, delays glucose absorption from the intestines, and enhances insulin sensitivity.

• Uses:

  • DIABETROL SR is prescribed to manage type 2 diabetes mellitus in adults when diet, exercise, and single-agent therapy are insufficient. It helps to enhance glycemic control and effectively lower blood glucose levels. It may also be indicated for maturity-onset diabetes and polycystic ovary syndrome.

• Dosage and Administration:

  • This medicine is taken orally, typically with meals, to minimize gastrointestinal side effects.
  • The tablet should be swallowed whole with water and not crushed, chewed, or broken.
  • Dosage and frequency (usually once or twice daily) are determined by a healthcare professional based on individual patient needs, age, body weight, and severity of the condition.

• Side Effects:

  • Common: Hypoglycemia (low blood sugar), which can present as sweating, dizziness, headache, shaking, increased hunger, or irritability. Gastrointestinal disturbances such as nausea, vomiting, diarrhea, stomach pain, flatulence, and altered taste are also common. Other common side effects include headache and weight gain.
  • Serious (Rare): Lactic acidosis (symptoms like severe abdominal pain, muscle cramps, vomiting, profound fatigue, difficulty breathing, decreased heartbeat, or reduced body temperature). Liver problems (e.g., jaundice, unusual fatigue). Long-term use may lead to vitamin B12 deficiency.

• Precautions:

  • DIABETROL SR is contraindicated in patients with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, severe allergic reactions to its components, or during pregnancy.
  • Avoid excessive alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
  • Caution is advised for patients with existing liver or kidney issues, and dosage adjustments may be necessary.
  • Regular monitoring of blood sugar levels is crucial. Patients should inform their doctor about all current medications to avoid potential drug interactions.
  • If dizziness or blurred vision occurs, activities like driving or operating machinery should be avoided. It is generally not recommended for breastfeeding mothers without medical consultation.

• Storage:

  • Store DIABETROL SR tablets at room temperature, ideally below 30°C (or 20-25°C).
  • Keep the medicine protected from moisture, heat, and direct sunlight.
  • Ensure it is kept out of the reach and sight of children and pets.
  • Always check the expiry date before use.

Here are some frequently asked questions about DIABETROL SR by Abbott:

What is DIABETROL SR used for?

DIABETROL SR is used to manage type 2 diabetes mellitus in adults. It is typically prescribed when diet, exercise, and single-agent therapy are not sufficient to control blood sugar levels. It helps to enhance glycemic control, especially in patients with higher baseline HbA1c levels.

How does DIABETROL SR work?

DIABETROL SR contains two active ingredients: Glibenclamide (5 mg) and Metformin (500 mg). Glibenclamide, a sulfonylurea, works by stimulating the beta cells in the pancreas to secrete more insulin. Metformin, a biguanide, primarily reduces glucose production in the liver, delays sugar absorption from the intestines, and enhances insulin sensitivity by increasing peripheral glucose uptake and use. The "SR" in DIABETROL SR stands for sustained release, which allows for a steady release of the medication over a prolonged period, potentially reducing dosing frequency.

What is the usual dosage for DIABETROL SR?

DIABETROL SR should be taken as prescribed by your doctor. It is usually taken orally with food, typically once or twice daily, at the same time each day, to minimize gastrointestinal side effects. Do not crush, chew, or break the tablet; swallow it whole with water. The exact dose and duration of therapy will depend on your age, body condition, and the severity of your diabetes.

What are the possible side effects of DIABETROL SR?

Common side effects of DIABETROL SR include hypoglycemia (low blood sugar levels), which can manifest as sweating, dizziness, headache, and shaking. Other common side effects may include nausea, vomiting, diarrhea, flatulence, abdominal pain, indigestion, altered taste, and headache. Serious but rare side effects can include lactic acidosis (characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing) and, with long-term use, vitamin B12 deficiency, which may cause anemia and nerve issues. It is crucial to consult your doctor if any side effects persist, worsen, or if you experience any serious symptoms.

Is DIABETROL SR safe during pregnancy or breastfeeding?

DIABETROL SR is generally contraindicated during pregnancy. If you are pregnant or planning to conceive, it is important to discuss this with your doctor as it may cause toxic effects to the fetus. For breastfeeding mothers, DIABETROL SR is not recommended as its components may pass into breast milk. It is advised to consult your doctor before using this medicine while breastfeeding to evaluate potential risks and benefits.

Can DIABETROL SR be taken with other medications?

DIABETROL SR can interact with various medications. It is important to inform your doctor about all medicines you are currently taking, including over-the-counter drugs, herbal supplements, and other antidiabetic medications (like insulin or glimepiride). Interactions can occur with medicines used for high blood pressure (e.g., diuretics, ACE inhibitors), high cholesterol (e.g., fenofibrate), corticosteroids, thyroid products, and oral contraceptives. Taking DIABETROL SR with certain antibiotics or pain medications like ibuprofen can also affect blood sugar levels.

What precautions should be taken while using DIABETROL SR?

Avoid excessive alcohol consumption while taking DIABETROL SR, as it can increase the risk of hypoglycemia and lactic acidosis. Caution is advised for patients with liver or kidney health issues, and dose adjustments may be necessary. It is contraindicated in severe kidney disease. Patients with heart failure, adrenal or pituitary insufficiency, or those who are severely dehydrated or malnourished should use this medicine with caution. DIABETROL SR is not suitable for type 1 diabetes mellitus. Regular monitoring of blood sugar levels is crucial, and it is recommended to carry a quick source of sugar (like glucose tablets or fruit juice) to manage potential hypoglycemia.

What happens if a dose of DIABETROL SR is missed?

If you forget to take a dose of DIABETROL SR, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should DIABETROL SR be stored?

DIABETROL SR tablets should be stored at room temperature, ideally below 30°C, and protected from moisture and heat. Keep the medicine out of the sight and reach of children and pets. Always check the expiry date and discard any unused or expired medicine properly.

What does the 'SR' in DIABETROL SR mean?

The 'SR' in DIABETROL SR stands for "Sustained Release". This formulation allows the active ingredients to be released slowly over an extended period, providing a steady therapeutic effect and often reducing the frequency of dosing compared to immediate-release formulations.