Azoran 25 Mg Tablet (25 Tab)

AZORAN 25 MG TABLET

AZORAN 25 MG TABLET, manufactured by RPG Life Sciences Limited, is an immunosuppressant medication.

• Name: Azoran 25 mg Tablet

• Composition: Each tablet contains Azathioprine 25 mg as the active ingredient.

• Uses:

  • Organ Transplant Rejection Prevention: It is primarily used with other medicines to prevent the body from rejecting transplanted organs such as kidneys, liver, heart, lung, or pancreas.
  • Rheumatoid Arthritis: It helps manage severe active rheumatoid arthritis by reducing pain, inflammation, stiffness, and slowing down joint damage.
  • Other Autoimmune Conditions: Azoran 25 Tablet is also used to treat various other autoimmune conditions where the immune system mistakenly attacks the body, including systemic lupus erythematosus, inflammatory bowel diseases (Crohn's disease and ulcerative colitis), autoimmune hepatitis, and certain severe skin or blood disorders.

• Dosage and Administration:

  • The dosage and frequency are determined by a healthcare provider based on the specific medical situation.
  • It can be taken with or without food, but if stomach upset occurs, it may be taken with food.
  • Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • Take the medicine regularly, ideally at the same time each day, and do not stop suddenly without consulting a doctor.

• Side Effects:

  • Common Side Effects: Nausea, vomiting, diarrhea, loss of appetite, stomach pain, headache, unusual fatigue, dizziness, tingling sensation, and sore throat.
  • Serious Side Effects: Decreased white blood cell count (leukopenia), increased bleeding tendency, bone marrow suppression, increased susceptibility to infections (viral, fungal, bacterial), and an increased risk of developing certain types of cancers (e.g., lymphoma, skin cancer).

• Precautions:

  • Pregnancy and Breastfeeding: It is not recommended during pregnancy or breastfeeding due to the risk of birth defects, miscarriages, and potential harm to the baby's immune system. Effective contraception is required during treatment and for 6 months after stopping.
  • Liver and Kidney Issues: Use with caution in patients with mild to moderate liver or kidney impairment, and dosage adjustments may be necessary. It is not recommended for severe liver disease.
  • Blood Disorders: Inform your doctor if you have severe blood disorders, bone marrow problems, or a deficiency in the TPMT enzyme, as Azoran can cause bone marrow suppression.
  • Infections: Due to its immune-suppressing effects, individuals may be more susceptible to infections. Avoid contact with people who have contagious illnesses.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of liver damage and worsen side effects.
  • Drug Interactions: Inform your doctor about all other medications being taken, especially xanthine oxidase inhibitors (e.g., allopurinol, febuxostat), anticoagulants (e.g., warfarin), aminosalicylates (e.g., sulfasalazine, mesalazine), antibiotics (e.g., cotrimoxazole, trimethoprim), and ACE inhibitors.
  • Monitoring: Regular blood tests are necessary to monitor blood cell counts and liver function.

• Storage: Store in a cool and dry place away from sunlight, typically below 25°C or 30°C. Keep out of sight and reach of children.

Here are the most frequently asked questions about AZORAN 25 MG TABLET:

What is Azoran 25 MG Tablet used for?

Azoran 25 MG Tablet is an immunosuppressant medicine primarily used to prevent the body from rejecting transplanted organs, such as kidneys, hearts, or livers. It is also used to manage various autoimmune and inflammatory conditions where the immune system mistakenly attacks the body's own tissues. These conditions include severe rheumatoid arthritis, autoimmune hepatitis, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, and certain severe inflammatory skin and blood disorders.

How does Azoran 25 MG Tablet work?

Azoran 25 MG Tablet contains Azathioprine, which is an immunosuppressant. It works by reducing the activity of the body's immune system. Specifically, it reduces the function of cells that cause inflammation, inhibits the synthesis of DNA, RNA, and proteins, and interferes with purine synthesis, all of which are crucial for the rapid multiplication of immune cells. This action helps to prevent the immune system from attacking a transplanted organ or from causing inflammation in autoimmune diseases.

What is the usual dosage for Azoran 25 MG Tablet?

The dosage of Azoran 25 MG Tablet varies depending on the medical condition and the patient's body weight. For adults, the usual starting dose ranges from 1 to 3 mg per kilogram of body weight per day, taken once or twice daily. In organ transplant prevention, initial doses might be 3-5 mg/kg/day, followed by a maintenance dose of 1-3 mg/kg/day. For rheumatoid arthritis, the dose may start lower (1 mg/kg/day) and be gradually increased. It can be taken with or without food, but taking it with or after meals may help reduce stomach upset. It should not be taken with milk or dairy products as they can reduce its effectiveness. Always follow your doctor's specific instructions.

What are the possible side effects of Azoran 25 MG Tablet?

Common side effects can include nausea, vomiting, diarrhea, loss of appetite, headaches, dizziness, unusual fatigue, stomach pain, sore throat, and increased liver enzymes. More serious side effects can occur due to its immunosuppressive nature, such as a lowered resistance to infections, decreased white blood cell count (leukopenia), bone marrow suppression, and an increased risk of developing certain cancers (e.g., skin cancer, lymphoma, leukemia). If you experience persistent or severe side effects, or signs of infection (fever, chills), unusual bleeding or bruising, or any changes in your skin, contact your doctor immediately.

Is Azoran 25 MG Tablet safe during pregnancy or breastfeeding?

No, Azoran 25 MG Tablet is generally not recommended during pregnancy (Pregnancy Category D) as it can cause birth defects and miscarriages. Women of childbearing potential should use effective contraception during treatment and for up to 3 months after stopping the medication. It is also not recommended for use during breastfeeding because the active ingredient, Azathioprine, can pass into breast milk and may adversely affect the nursing baby. Always discuss your pregnancy or breastfeeding status with your doctor.

Can Azoran 25 MG Tablet be taken with other medications?

Azoran 25 MG Tablet can interact with various other medications. It is crucial to inform your doctor about all prescription drugs, over-the-counter medicines, supplements, and herbal products you are currently taking or plan to take. Notable interactions include those with medicines for gout (like allopurinol), other immunosuppressants, blood thinners (like warfarin), aminosalicylates (e.g., sulfasalazine, mesalazine), certain antibiotics (like cotrimoxazole, trimethoprim), and ACE inhibitors. Combining Azoran with some of these can increase the risk of severe side effects like bone marrow suppression or alter the effectiveness of either drug. Live virus vaccines should generally be avoided while on Azoran.

What precautions should be taken while on Azoran 25 MG Tablet?

Several precautions are important when taking Azoran 25 MG Tablet. Do not take it if you are allergic to azathioprine or similar immunosuppressants. Inform your doctor if you have liver or kidney problems, serious blood disorders, immune system issues, bone marrow problems, untreated infections, immunodeficiency syndrome, or a condition where your body produces too little thiopurine methyltransferase (TPMT). Regular blood tests are essential to monitor your blood cell counts, and liver and kidney function. Due to an increased risk of skin cancer, avoid prolonged sun exposure and use protective clothing and sunscreen. Avoid consuming alcohol, as it can increase dizziness and liver-related side effects. Do not stop taking the medicine suddenly without consulting your doctor, as this can worsen your condition or lead to organ rejection.

What happens if a dose of Azoran 25 MG Tablet is missed?

If you miss a dose of Azoran 25 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose or extra doses to make up for the missed one, as this could lead to dangerous side effects. If you frequently miss doses, consider setting an alarm or asking your pharmacist for advice on how to remember your medication.

How should Azoran 25 MG Tablet be stored?

Azoran 25 MG Tablet should be stored at room temperature, typically below 25°C or 30°C, away from excessive moisture and light. Keep the tablets in their original, tightly closed container to protect them from damage. It is crucial to store this medicine out of the sight and reach of children to prevent accidental ingestion. Regularly check the expiration date and dispose of any unused or expired medication properly as advised by your pharmacist or local waste disposal company.