Ivabrad 7.5 Tablet

IVABRAD 7.5 TABLET

Name: Ivabrad 7.5 Tablet. The common name for the active ingredient is Ivabradine.

Composition: Each tablet contains Ivabradine 7.5 mg.

Uses: Ivabrad 7.5 Tablet is prescribed for adults for the symptomatic treatment of chronic stable angina pectoris (heart-related chest pain) and chronic heart failure. It is particularly indicated for patients with symptomatic stable angina pectoris whose heart rate is 70 beats per minute or above, or for chronic heart failure patients with a heart rate of 75 beats per minute or higher. This medication works by selectively inhibiting the If current in the sinoatrial node, which slows the heart rate and reduces the heart's oxygen demand, thereby improving blood flow and alleviating chest pain.

Dosage and Administration: Ivabrad 7.5 Tablet should be taken orally, preferably with food, twice daily (once in the morning and once in the evening). The dose and duration of treatment are determined by a healthcare professional based on the patient's condition. It is crucial to take the medicine at the same time daily and not to discontinue it abruptly without consulting a doctor, as this can worsen the condition. Dose adjustments may be necessary, aiming for a target resting heart rate between 50 and 60 beats per minute.

Side Effects:

• Common Side Effects: Headache, dizziness, blurred vision (luminous phenomena or enhanced brightness), slow heart rate (bradycardia), high blood pressure, atrial fibrillation, nausea, diarrhea, and abdominal pain.
• Serious Side Effects: Fainting and significant changes to your heartbeat may require urgent medical attention.

Precautions:

• Contraindications: Ivabrad 7.5 Tablet is not recommended for use if you have severe liver problems, low blood pressure (<90/50mm Hg), acute decompensated heart failure, sick sinus syndrome, third-degree AV block, or if your heart rate is controlled by a pacemaker. It is also contraindicated in cases of cardiogenic shock, acute myocardial infarction, or hypersensitivity to its ingredients.
• Pregnancy and Breastfeeding: This medicine is highly unsafe during pregnancy as it may harm the unborn baby, and it is not recommended during breastfeeding due to lack of safety information.
• Drug Interactions: Inform your doctor about all current medications, including herbal and supplement products. Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin, diltiazem, verapamil) is not recommended. Caution is advised with CYP3A4 inducers (e.g., rifampicin, phenytoin) and water pills, as they may cause reduced heartbeats. Avoid grapefruit juice while on this medication as it may increase its concentration in the body.
• General Warnings: Ivabrad 7.5 Tablet may cause dizziness or blurred vision, so avoid driving or operating machines if you experience these symptoms. Blood pressure and heart rate should be monitored regularly during treatment. It is not recommended for use in children below 18 years of age.

Storage: Store Ivabrad 7.5 Tablet at room temperature, below 30°C, protected from moisture and heat. Keep it out of reach and sight of children and pets.

IVABRAD 7.5 TABLET, manufactured by Lupin Ltd, contains Ivabradine (7.5mg) as its active ingredient. It is a heart rate lowering medication used to manage certain heart conditions.

What is IVABRAD 7.5 TABLET used for?

IVABRAD 7.5 TABLET is primarily used for the symptomatic treatment of chronic stable angina pectoris (heart-related chest pain) and chronic (long-term) heart failure. It helps to reduce the risk of hospitalization for worsening heart failure.

How does IVABRAD 7.5 TABLET work?

This medication works by selectively inhibiting a specific "pacemaker" current, known as the "funny" channel (I_f), in the sinoatrial node of the heart. This action slows down the heart rate without affecting the heart's pumping strength (contractility) or other electrical activities. By reducing the heart rate, it lowers the heart's oxygen demand and improves blood flow to the heart muscle, making it more efficient.

What is the usual dosage for IVABRAD 7.5 TABLET?

For adults, the usual starting dose is 5 mg taken twice daily with food. Your doctor may adjust the dose after two weeks to achieve a resting heart rate between 50 and 60 beats per minute. The maximum dose is typically 7.5 mg twice daily. For children weighing 40 kg or more, the initial dose is 2.5 mg twice daily, which can be adjusted up to a maximum of 7.5 mg twice daily. It is important to take this medicine with meals.

What are the possible side effects of IVABRAD 7.5 TABLET?

Common side effects include a slow heartbeat (bradycardia), which may cause dizziness, fainting, or shortness of breath. Other frequent side effects include luminous phenomena (temporary bright spots or flashes in vision), increased blood pressure, headache, and atrial fibrillation (an irregular heart rhythm). If you experience serious side effects like a very slow or irregular heartbeat, severe dizziness, or chest pain, seek immediate medical attention.

Is IVABRAD 7.5 TABLET safe during pregnancy or breastfeeding?

IVABRAD 7.5 TABLET is not considered safe during pregnancy as it can harm an unborn baby. Females who are able to become pregnant must use effective contraception during treatment. Breastfeeding is not recommended while taking this medication because Ivabradine is present in rat milk, and there is a potential risk to breastfed infants.

Can IVABRAD 7.5 TABLET be taken with other medications?

IVABRAD 7.5 TABLET has several important drug interactions. It should not be taken with strong CYP3A4 inhibitors, such as certain antifungal medications (e.g., ketoconazole, itraconazole), macrolide antibiotics (e.g., clarithromycin), medicines for HIV, nefazodone (for depression), or certain calcium channel blockers like diltiazem and verapamil, as these can significantly increase ivabradine levels and risk of bradycardia. Concomitant use with other drugs that slow heart rate, such as beta-blockers, digoxin, or amiodarone, requires careful monitoring of heart rate. Grapefruit and grapefruit juice should be avoided.

What precautions should be taken while using IVABRAD 7.5 TABLET?

Before taking IVABRAD 7.5 TABLET, inform your doctor if you have a resting heart rate below 60 bpm, very low blood pressure, decompensated heart failure, certain heart rhythm disorders (e.g., sick sinus syndrome, 3rd-degree AV block) without a pacemaker, or severe liver problems, as this medicine may be contraindicated. Visual changes, such as temporary brightness, can occur, so exercise caution when driving or operating machinery, especially at night or in areas with sudden light changes. Regular monitoring of your heart rate and blood pressure is important during treatment.

What happens if a dose of IVABRAD 7.5 TABLET is missed?

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the forgotten dose.

How should IVABRAD 7.5 TABLET be stored?

Store IVABRAD 7.5 TABLET at room temperature, typically between 68°F to 77°F (20°C to 25°C), away from heat, moisture, and direct light. Keep it in a closed container and out of the reach of children and pets. Do not freeze the medicine.