Pregalin Nt 50/10mg Tab

PREGALIN NT 50/10MG Tablet

Name

Brand Name: PREGALIN NT 50/10MG Tablet Manufacturer: TORRENT PHARMACEUTICALS LTD

Composition

Each tablet contains:

• Pregabalin: 50 mg
• Nortriptyline: 10 mg

Uses

PREGALIN NT 50/10MG Tablet is a combination medicine primarily used for the management of neuropathic pain. Neuropathic pain is a chronic condition caused by nerve damage or a malfunctioning nervous system, leading to sensations like burning, shooting, stabbing, or electric shock-like pain. It is specifically indicated for:

• Diabetic peripheral neuropathy
• Postherpetic neuralgia
• Pain associated with spinal cord injury
• Fibromyalgia
• Generalized Anxiety Disorder (GAD)
• Epilepsy (as adjunctive therapy for partial seizures)
• Depression and other mood disorders

Dosage and Administration

PREGALIN NT 50/10MG Tablet should be taken exactly as directed by your physician. It can be taken with or without food. Swallow the tablet whole with a glass of water; do not crush, break, or chew it. It is advisable to take the medicine at the same time each day to maintain consistent levels in the body. Do not stop taking this medicine abruptly without consulting your doctor, as it may lead to withdrawal symptoms.

Side Effects

Common side effects of PREGALIN NT 50/10MG Tablet may include:

• Dizziness
• Sleepiness/Drowsiness
• Nausea
• Blurred vision
• Peripheral oedema (swelling of lower legs and hands)
• Weight gain
• Dry mouth
• Constipation
• Headache
• Difficulty in urination
• Confusion
• Tiredness and weakness
• Uncoordinated body movements
• Increased heart rate
• Orthostatic hypotension (sudden lowering of blood pressure on standing)

Serious side effects to monitor for include allergic reactions (e.g., swelling of face, lips, tongue), severe dizziness, breathing difficulty, and unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Consult your doctor if any side effects persist or worsen.

Precautions

• Alcohol: Avoid consuming alcohol, as it can increase drowsiness and dizziness.
• Driving & Operating Machinery: Due to potential drowsiness, dizziness, and blurred vision, avoid driving or operating heavy machinery until you understand how the medication affects you.
• Pregnancy & Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor, as safety information is limited and it may harm the baby.
• Pre-existing Conditions: Inform your doctor if you have heart problems, liver disease, kidney disease, diabetes, bipolar syndrome, or a history of angioedema.
• Drug Interactions: Inform your doctor about all medications you are taking, especially other antidepressants (including MAO inhibitors in the last 14 days) or cough/cold medicines containing adrenaline-like drugs.
• Children: Not recommended for use in children below 18 years of age as safety and effectiveness have not been established.
• Abrupt Discontinuation: Do not stop the medication suddenly, as it can lead to withdrawal symptoms. The dose should be gradually reduced under medical supervision.

Storage

Store PREGALIN NT 50/10MG Tablet in a cool and dry place, away from direct sunlight. Keep it out of sight and reach of children and pets. Recommended storage temperature is between 10ºC to 25ºC or below 30ºC.

What is PREGALIN NT 50/10MG TAB used for?

PREGALIN NT 50/10MG TAB is a combination medicine primarily used for the management of neuropathic pain, which is pain caused by nerve damage or a malfunctioning nervous system. This includes conditions such as diabetic peripheral neuropathy, postherpetic neuralgia (nerve pain after shingles), fibromyalgia, and pain associated with spinal cord injury. It may also be used in the treatment plan for certain types of epilepsy and chronic low back pain.

How does PREGALIN NT 50/10MG TAB work?

This medicine combines two active ingredients: Pregabalin (an anti-convulsant/analgesic) and Nortriptyline (a tricyclic antidepressant). Pregabalin works by reducing the release of certain chemicals in the brain that transmit pain signals across the nervous system, essentially dampening the amplified pain signals from damaged nerves. Nortriptyline increases the levels of specific nerve transmitters, such as serotonin and noradrenaline, in the brain. These neurotransmitters help regulate mood and reduce the pain messages reaching the brain. Together, they provide a synergistic effect to alleviate neuropathic pain.

What is the usual dosage for PREGALIN NT 50/10MG TAB?

The dosage of PREGALIN NT 50/10MG TAB should be strictly as advised by your doctor, based on your clinical condition and response to treatment. It is typically taken at the same time each day, and can be consumed with or without food. The tablet should be swallowed whole with water; do not crush, break, or chew it. Never take more than the prescribed dose, and do not stop the medication suddenly without consulting your doctor, as this can lead to withdrawal symptoms.

What are the possible side effects of PREGALIN NT 50/10MG TAB?

Common side effects include dizziness, sleepiness/drowsiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain, and dry mouth. Other possible side effects can be constipation, aggression, headache, nasal congestion, insomnia, difficulty in urination, tiredness, uncoordinated body movements, shakiness, increased heart rate, and sudden lowering of blood pressure on standing (orthostatic hypotension). Most of these side effects are usually temporary and resolve over time, but you should consult your doctor if they persist or become bothersome.

Is PREGALIN NT 50/10MG TAB safe during pregnancy or breastfeeding?

During Pregnancy: PREGALIN NT 50/10MG TAB is generally not recommended during pregnancy due to limited information regarding its safety for the developing baby. If you are pregnant or become pregnant while taking this medication, inform your doctor immediately, who will assess the benefits versus risks.

During Breastfeeding: It is recommended not to breastfeed while taking PREGALIN NT 50/10MG TAB, as its components may pass into breast milk and potentially harm the nursing infant. Your doctor will advise whether to discontinue breastfeeding or the medication.

Can PREGALIN NT 50/10MG TAB be taken with other medications?

It is crucial to inform your doctor about all prescription and over-the-counter medicines, herbal products, and supplements you are currently taking or plan to take to avoid potential drug interactions. PREGALIN NT 50/10MG TAB should not be taken with Monoamine Oxidase Inhibitors (MAOIs), a class of antidepressants, and a gap of at least 14 days is required between stopping MAOIs and starting this medicine. Caution is also advised with cough-cold medicines containing adrenaline-like drugs (e.g., ephedrine), other medications that cause drowsiness (such as antihistamines, sleep aids, muscle relaxants, or narcotic pain relievers), and drugs that increase serotonin levels (like certain antidepressants or St. John's wort) due to increased risk of side effects like serotonin syndrome.

What precautions should be taken while using PREGALIN NT 50/10MG TAB?

This medication may cause drowsiness and dizziness, so avoid driving or operating heavy machinery until you understand how it affects you. Alcohol consumption should be avoided as it can increase drowsiness and dizziness. Do not stop taking the medicine abruptly, as it can lead to withdrawal symptoms such as anxiety, sleep difficulties, headache, nausea, and even seizures; your doctor will guide you on gradually reducing the dose. Inform your doctor if you have pre-existing conditions like heart problems, liver or kidney disease, diabetes, glaucoma, bipolar disorder, or a history of seizures. It is also important to monitor for any unusual mood changes or suicidal thoughts and report them to your doctor immediately. This medicine is not recommended for children as its safety and effectiveness have not been established.

What happens if a dose of PREGALIN NT 50/10MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can increase the risk of side effects. Missing doses can potentially lead to a rise in blood pressure or trigger seizures if you are taking it for epilepsy.

How should PREGALIN NT 50/10MG TAB be stored?

PREGALIN NT 50/10MG TAB should be stored in a cool and dry place, away from direct sunlight and moisture. Maintain a storage temperature between 10ºC to 25ºC or below 30ºC. Always keep the medicine out of the sight and reach of children and pets.