Duzela M 20 Mg Capsule (10 Cap)

DUZELA M 20 MG CAPSULE

DUZELA M 20 MG CAPSULE is a combination medication manufactured by Sun Pharmaceutical Industries Ltd..

• Name:

  • Brand Name: Duzela M 20 Capsule DR, DUZELA M 20 MG CAPSULE.
  • Common Name: Duloxetine and Methylcobalamin Capsules.

• Composition:

  • Each capsule contains Duloxetine 20 mg and Methylcobalamin 1.5 mg. Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI), and Methylcobalamin is a form of Vitamin B12.

• Uses: DUZELA M 20 MG CAPSULE is prescribed for a variety of conditions, primarily focusing on neuropathic pain and mood disorders.

  • Neuropathic Pain: Including diabetic peripheral neuropathy (nerve damage due to diabetes), chronic musculoskeletal pain, and pain associated with shingles or spinal cord injury.
  • Mood Disorders: Major Depressive Disorder and Generalized Anxiety Disorder.
  • Other Conditions: Fibromyalgia and moderate to severe stress urinary incontinence in women.

• Dosage and Administration:

  • DUZELA M 20 MG CAPSULE should be taken orally, with or without food, as directed by a doctor.
  • It is recommended to take the capsule at the same time daily to maintain consistent medicine levels in the body.
  • Capsules should be swallowed whole and not crushed, chewed, or broken.
  • The full treatment course should be completed, and the medication should not be stopped abruptly without consulting a doctor, as this can lead to withdrawal symptoms.

• Side Effects:

  • Common Side Effects: Nausea, dry mouth, headache, constipation, drowsiness, insomnia (difficulty sleeping), ejaculation disorder, erectile dysfunction, low libido (decreased sexual desire), increased sweating, dizziness, blurred vision, fatigue, and changes in weight. These often resolve over time.
  • Serious Side Effects: Allergic reactions, severe skin reactions (e.g., Stevens-Johnson syndrome), signs of liver disease (dark urine, yellowing of skin/eyes, upper right abdominal pain), abnormal mood or behavior changes including suicidal thoughts, agitation, tremors, seizures, hallucinations, heart palpitations, fainting, gastrointestinal issues (e.g., vomiting blood), abnormal vaginal bleeding, chest pain, and low sodium levels.

• Precautions:

  • Contraindications: Not recommended for patients with severe liver or kidney disease, uncontrolled narrow-angle glaucoma, or those taking monoamine oxidase inhibitors (MAOIs).
  • Specific Warnings:
    • Pregnancy and Breastfeeding: Use during pregnancy is generally discouraged unless necessary, and breastfeeding women should avoid this medicine as it can pass into breast milk.
    • Children and Elderly: Not recommended for children and adolescents under 18; older patients (above 65) should use it with caution.
    • Alcohol: Avoid alcohol consumption as it may aggravate side effects and increase the risk of liver injury.
    • Activities Requiring Alertness: May cause drowsiness or dizziness, so caution is advised when driving or operating heavy machinery.
    • Pre-existing Conditions: Inform your doctor about any history of heart issues, high blood pressure, kidney disease, liver disease, seizures, mania, bipolar disorder, glaucoma, bleeding disorders, or risk of hyponatremia (low sodium levels).
    • Suicidal Thoughts: Closely observe for any changes in mood or behavior due to the increased risk of suicidal thoughts.
    • Drug Interactions: Inform your doctor about all current medications, especially other antidepressants, blood thinners, ciprofloxacin, dextromethorphan, and diuretics.
    • Diabetes: Use with caution in diabetic patients due to potential alteration in blood glucose levels; monitoring is necessary.

• Storage:

  • Store in dry conditions at room temperature, preferably below 30°C.
  • Keep out of sight and reach of children, and away from direct sunlight.

DUZELA M 20 MG CAPSULE is a combination medication containing Duloxetine (20mg) and Methylcobalamin (1.5mg). It is primarily used to manage various conditions, including neuropathic pain, mood disorders, and certain chronic pain conditions.

What is DUZELA M 20 MG CAPSULE used for?

DUZELA M 20 MG CAPSULE is prescribed for several conditions, including chronic pain caused by nerve damage (neuropathic pain) due to diabetes, shingles, or spinal cord injury. It is also used to treat major depressive disorder, generalized anxiety disorder (GAD), fibromyalgia, and chronic muscle or joint pain. In some cases, it may be used to manage moderate to severe stress urinary incontinence in women.

How does DUZELA M 20 MG CAPSULE work?

This medicine works through its two active ingredients. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), increases the levels of natural chemical messengers (serotonin and norepinephrine) in the brain. This helps regulate mood and pain signals. Methylcobalamin, a form of Vitamin B12, is essential for rejuvenating and protecting damaged nerve cells by assisting in the production of myelin, a protective layer around nerve fibers. This improves nerve conduction and helps repair damaged nerves.

What is the usual dosage for DUZELA M 20 MG CAPSULE?

The dosage of DUZELA M 20 MG CAPSULE is determined by your doctor based on your age, health condition, and how you respond to the treatment. It is usually advised to take the capsule once daily, with or without food, and at the same time each day to maintain consistent medicine levels in your body. Do not crush, chew, or break the capsule; swallow it whole with a glass of water.

What are the possible side effects of DUZELA M 20 MG CAPSULE?

Common side effects may include nausea, constipation, headache, difficulty sleeping (insomnia), ejaculation disorder, erectile dysfunction, decreased sexual desire, dizziness, dry mouth, increased sweating, fatigue, weight changes, drowsiness, and loss of appetite.

More serious, but less common, side effects can include suicidal thoughts or behavior, severe skin reactions, liver problems (such as yellowing of the skin or eyes, dark urine, or upper right abdominal pain), allergic reactions, agitation, tremors, seizures, hallucinations, changes in blood pressure, low blood sodium levels, abnormal bleeding, and vision problems. If you experience any severe or persistent side effects, or any unusual changes in mood or behavior, contact your doctor immediately.

Is DUZELA M 20 MG CAPSULE safe during pregnancy or breastfeeding?

Pregnancy: The use of DUZELA M 20 MG CAPSULE during pregnancy is generally discouraged unless absolutely necessary and prescribed by a doctor, as animal studies have shown potential adverse effects on the baby. Breastfeeding: It is advisable to avoid this medicine while breastfeeding as it can pass into breast milk. Always consult your doctor to discuss the potential risks and benefits.

Can DUZELA M 20 MG CAPSULE be taken with other medications?

DUZELA M 20 MG CAPSULE can interact with other medications. It should not be taken within 14 days after or 5 days before taking monoamine oxidase inhibitors (MAOIs), such as rasagiline, selegiline, or linezolid, due to the risk of serious drug interactions. Caution is advised if you are taking medications that affect blood clotting, diuretics, Ciprofloxacin, or Dextromethorphan. Always inform your doctor about all other medications, herbal remedies, and supplements you are currently taking to avoid potential adverse effects.

What precautions should be taken while using DUZELA M 20 MG CAPSULE?

Do not stop taking DUZELA M 20 MG CAPSULE abruptly, even if your symptoms improve, as this can lead to withdrawal symptoms. Report any unusual changes in mood or behavior, especially suicidal thoughts, to your doctor immediately. Use with caution if you have a history of liver or kidney disease, heart conditions, high blood pressure, glaucoma, seizures, mania, bipolar disorder, bleeding disorders, or diabetes. This medicine may cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you. Regular medical check-ups might be necessary to monitor blood pressure, blood sugar levels, and sodium levels. Avoiding alcohol consumption while on this medication is also advised as it may worsen certain side effects and increase the risk of liver injury.

What happens if a dose of DUZELA M 20 MG CAPSULE is missed?

If you miss a dose of DUZELA M 20 MG CAPSULE, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. It is important to complete the full course of treatment as prescribed by your doctor.

How should DUZELA M 20 MG CAPSULE be stored?

DUZELA M 20 MG CAPSULE should be stored in a cool and dry place, below 30°C, away from direct sunlight and moisture. Keep this medicine out of the sight and reach of children and pets.