Trinexovas 40 Mg Tablet (15 Tab)

TRINEXOVAS 40 MG TABLET

TRINEXOVAS 40 MG TABLET, manufactured by Macleods Pharmaceuticals Ltd., is a combination medication primarily prescribed for the management of hypertension (high blood pressure). It helps to effectively lower blood pressure, thereby reducing the risk of associated cardiovascular complications like heart attack and stroke.

• Name:

  • Brand Name: TRINEXOVAS 40 MG TABLET
  • Common Name: Chlorthalidone + Cilnidipine + Olmesartan

• Composition:

  • Each tablet contains:
    • Chlorthalidone (12.5 mg)
    • Cilnidipine (10 mg)
    • Olmesartan Medoxomil (40 mg)

• Uses: TRINEXOVAS 40 MG TABLET is used to treat:

  • Hypertension (high blood pressure) in adults, particularly when a single medication is insufficient for adequate blood pressure control. It works by relaxing blood vessels, improving blood flow, and helping the body eliminate excess water and certain electrolytes.

• Dosage and Administration:

  • Take this medicine in the dose and duration as advised by your doctor.
  • It should be swallowed whole with a glass of water. Do not chew, crush, or break the tablet.
  • It is recommended to take TRINEXOVAS 40 MG TABLET with food at the same time each day to ensure optimal effectiveness and avoid stomach upset.
  • Due to its diuretic effect, it is advisable to refrain from taking it within four hours of bedtime to avoid increased urination at night.
  • Do not discontinue the medication without consulting your doctor, as abrupt cessation can increase the risk of heart attack or stroke.

• Side Effects:

  • Common Side Effects: Headache, dizziness, tiredness or weakness, nausea, peripheral oedema (swelling of legs/hands), increased urination frequency, dry mouth, stomach pain, constipation, altered blood lipid levels, and taste changes.
  • Serious Side Effects: Low blood pressure (hypotension), swelling of face, lips, eyelids, tongue, hands and feet, muscle pain, skin rash, and hyperkalemia (increased potassium levels in the blood) which can lead to cardiac rhythm irregularities.

• Precautions:

  • Inform your doctor if you have known allergies to any of its components or other sulfonamides or angiotensin-receptor blockers.
  • Exercise caution in patients with kidney disease, liver disease (not recommended for severe liver impairment), heart failure, low blood pressure, and diabetes.
  • Avoid consuming alcohol as it may intensify side effects like dizziness and lightheadedness.
  • Grapefruit juice should be avoided as it can interact with cilnidipine.
  • Not recommended for use during pregnancy or breastfeeding.
  • Avoid potassium-rich foods and potassium supplements unless advised by your doctor due to the risk of hyperkalemia.
  • Regular monitoring of blood pressure, kidney function, electrolyte levels, and blood sugar is advisable.

• Storage:

  • Store below 30°C.

TRINEXOVAS 40 MG TABLET (15 TAB) by MACLEODS PHARMACEUTICALS LTD. is a combination medication used to manage high blood pressure. Here are some frequently asked questions and their answers:

What is TRINEXOVAS 40 MG TABLET used for?

TRINEXOVAS 40 MG TABLET is primarily used to treat essential hypertension (high blood pressure) in adults. It is often prescribed for patients who require multiple medications to effectively control their blood pressure. By lowering blood pressure, it helps reduce the risk of cardiovascular complications such as heart attacks and strokes.

How does TRINEXOVAS 40 MG TABLET work?

This medicine is a combination of three active ingredients: Olmesartan Medoxomil, Cilnidipine, and Chlorthalidone. Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB), relaxes and widens blood vessels by blocking the action of angiotensin II. Cilnidipine, a calcium channel blocker (CCB), also relaxes blood vessels by blocking calcium entry into heart and vessel cells. Chlorthalidone, a thiazide-like diuretic, works by increasing the excretion of water and sodium from the kidneys, which helps reduce blood volume and overall blood pressure. Together, these components synergistically lower blood pressure and reduce the heart's workload.

What is the usual dosage for TRINEXOVAS 40 MG TABLET?

Typically, one tablet is taken once daily, preferably at the same time each day. It can be taken with or without food. However, since it contains a diuretic, it's generally advised to avoid taking it within four hours of going to bed to prevent frequent urination during the night. Your doctor will determine the appropriate dose and duration based on your condition and how you respond to the medication.

What are the possible side effects of TRINEXOVAS 40 MG TABLET?

Common side effects may include dizziness, headache, tiredness or weakness, nausea, peripheral oedema (swelling of legs/hands), and increased urination. More serious side effects, though less common, can include severe low blood pressure, allergic reactions (like swelling of the face, lips, or tongue), and electrolyte imbalances (such as high potassium levels or changes in sodium). If you experience persistent or severe side effects, or any signs of an allergic reaction or irregular heartbeat, seek immediate medical attention.

Is TRINEXOVAS 40 MG TABLET safe during pregnancy or breastfeeding?

No, TRINEXOVAS 40 MG TABLET is generally not recommended for use during pregnancy or if you are planning to become pregnant, as it may harm the unborn baby. It is also not recommended for breastfeeding women, as components of the medicine may pass into breast milk, and its effects on the infant are unknown. Always consult your doctor for alternative, safer treatment options if you are pregnant or breastfeeding.

Can TRINEXOVAS 40 MG TABLET be taken with other medications?

TRINEXOVAS 40 MG TABLET can interact with several other medications. For instance, co-administration with aliskiren, lithium, NSAIDs (non-steroidal anti-inflammatory drugs), certain potassium-sparing diuretics, and potassium supplements should be done with caution or avoided. It may also interact with other blood pressure-lowering medicines, digoxin, cimetidine, rifampicin, and some antifungal medications. Always inform your doctor about all prescription drugs, over-the-counter medicines, and herbal supplements you are taking to prevent potential drug interactions.

What precautions should be taken while taking TRINEXOVAS 40 MG TABLET?

Avoid consuming alcohol and grapefruit juice while on this medication, as they can intensify side effects or increase drug levels in your body. Exercise caution if you have underlying conditions such as kidney disease, liver disease, heart failure, diabetes, or gout, as dosage adjustments or close monitoring may be necessary. Regular monitoring of your blood pressure, kidney function, and electrolyte levels is recommended. Do not drive or operate heavy machinery if you experience dizziness or tiredness. It is not recommended for children and should be used with caution in elderly patients (65 years and above).

What happens if a dose of TRINEXOVAS 40 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should TRINEXOVAS 40 MG TABLET be stored?

Store TRINEXOVAS 40 MG TABLET in a cool and dry place, typically below 30°C. Keep it away from direct sunlight, heat, and moisture. Ensure it is kept out of the reach of children and pets.