Xafinact 100mg Tablet

XAFINACT 100MG TABLET

XAFINACT 100MG TABLET by SUN PHARMA LABORATORIES LTD. is a medication primarily used in the management of Parkinson's disease.

Name

• Brand Name: XAFINACT 100MG TABLET
• Common Name: Safinamide 100mg Tablet

Composition

• Active Ingredient: Safinamide (100 mg)

Uses XAFINACT 100MG TABLET is prescribed for the management of Parkinson's disease in adults. It is commonly used as an add-on therapy, particularly for patients experiencing "off" episodes where standard medications become less effective, leading to worsened symptoms. The medication helps improve motor function, reduce tremors, muscle stiffness, and difficulty with movement by increasing dopamine levels in the brain, thereby enhancing overall quality of life.

Dosage and Administration The tablet should be swallowed whole with a glass of water, without crushing or chewing. It can be taken with or without food, preferably in the morning and at the same time each day to maintain consistent levels in the body. The exact dosage and duration are determined by a healthcare professional based on individual patient factors. It is crucial not to stop the medication abruptly, as this can lead to adverse effects like confusion, stiff muscles, and high fever.

Side Effects

• Common Side Effects: Cough, flu-like symptoms, insomnia (difficulty sleeping), involuntary muscle movement (dyskinesia), falls, nausea, dizziness, headache, depression, indigestion, joint pain, peripheral edema, urinary infections, and orthostatic hypotension (sudden drop in blood pressure upon standing).
• Serious Side Effects (Seek immediate medical attention): Blurred vision, fainting, chest pain, difficulty swallowing, signs of hypertensive crisis (e.g., anxiety, blurred vision, seizures), signs of neuroleptic malignant syndrome (e.g., confusion, muscle rigidity, high body temperature), and serotonin syndrome (e.g., confusion, hypertension, stiff muscles, hallucinations).

Precautions

• Contraindications: Not recommended for individuals with hypersensitivity to Safinamide, severe liver problems, or certain eye conditions like albinism, retinal degeneration, uveitis, inherited retinopathy, or severe progressive diabetic retinopathy.
• Interactions: Avoid concurrent use with other MAO inhibitors, opioid drugs (e.g., meperidine, tramadol), antidepressants, cyclobenzaprine, amphetamines, methylphenidate, St. John's Wort, and dextromethorphan due to the risk of serious adverse reactions like serotonin syndrome or hypertensive crisis.
• Dietary: Minimize or avoid high-protein diets as they can lead to an unsafe rise in blood pressure.
• Specific Populations: Consult a doctor if pregnant or breastfeeding. Use with caution in patients with kidney problems, mild to moderate liver impairment, schizophrenia, bipolar disorder, psychosis, high or low blood pressure, dyskinesia, or sleep problems. Driving or operating machinery should be avoided if experiencing dizziness or drowsiness.

Storage Store below 30°C, at controlled room temperature between 20°C to 25°C. Keep away from moisture, heat, and light, and do not freeze. Keep out of sight and reach of children and pets.

XAFINACT 100MG TABLET is a medication primarily used in the management of Parkinson's disease. It contains Safinamide, which works to improve motor symptoms and reduce "off" episodes in patients.

Here are some frequently asked questions about XAFINACT 100MG TABLET:

What is XAFINACT 100MG TABLET used for?

XAFINACT 100MG TABLET is used to treat Parkinson's disease in adults. It is often used as an add-on therapy, either alone or in combination with other anti-Parkinson medications like Levodopa, particularly in mid-late stage patients or to manage periods when standard medication loses effectiveness ("off" episodes). This medicine helps to provide better control of body movements, reducing symptoms such as tremors, stiffness, and difficulty with walking, coordination, and balance.

How does XAFINACT 100MG TABLET work?

XAFINACT 100MG TABLET contains Safinamide, which belongs to a group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine, a natural chemical messenger in the brain that is essential for controlling movement. By blocking the MAO-B enzyme that breaks down dopamine, Safinamide enhances dopamine levels, thereby improving motor function and reducing symptoms of Parkinson's disease.

What is the usual dosage for XAFINACT 100MG TABLET?

It is recommended to take XAFINACT 100MG TABLET once daily, preferably in the morning, at the same time each day, or as advised by your doctor. The tablet can be taken with or without food. It should be swallowed whole with a glass of water and not crushed, chewed, or broken. Your doctor will determine the correct dose and duration based on your age, body weight, and the severity of your condition.

What are the possible side effects of XAFINACT 100MG TABLET?

Common side effects may include cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, peripheral oedema, dizziness, headache, nausea, involuntary muscle movements (dyskinesia), and falls. More serious side effects, though less common, can include signs of hypertensive crisis (sudden severe increase in blood pressure with symptoms like anxiety, blurred vision, seizures), neuroleptic malignant syndrome (confusion, sweating, muscle rigidity, high body temperature), or serotonin syndrome (confusion, stiff muscles, hallucinations). If side effects persist, worsen, or if you experience any severe or unusual symptoms, consult your doctor immediately.

Is XAFINACT 100MG TABLET safe during pregnancy or breastfeeding?

XAFINACT 100MG TABLET is generally not recommended for use during pregnancy or in women planning for pregnancy, as it may be unsafe and animal studies have shown harmful effects on the developing baby. Women of childbearing potential should use effective contraceptive measures while taking this medicine. Similarly, it is not recommended for use in breastfeeding mothers, as it may pass into breast milk and is considered potentially unsafe. In both cases, your doctor will weigh the potential benefits and risks before prescribing.

Can XAFINACT 100MG TABLET be taken with other medications?

XAFINACT 100MG TABLET can be taken alone or in combination with other medicines for Parkinson's disease. However, it can interact with several medications. It should not be used concurrently or within 14 days of discontinuing other monoamine oxidase (MAO) inhibitors (such as selegiline, rasagiline, phenelzine, isocarboxazid, tranylcypromine), as this can increase the risk of high blood pressure and serotonin syndrome. Caution is also advised when taken with antidepressants (e.g., SSRIs, SNRIs, TCAs like fluoxetine, venlafaxine) and opioid pain medications (e.g., pethidine, tramadol, methadone) due to the potential risk of serotonin syndrome. Medicines used for cold or cough (e.g., dextromethorphan, ephedrine, pseudoephedrine) may also interact. Always inform your doctor about all prescription, over-the-counter, nutritional supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken while using XAFINACT 100MG TABLET?

Do not stop taking XAFINACT 100MG TABLET suddenly without consulting your doctor, as abrupt discontinuation can lead to adverse effects such as confusion, stiff muscles, and high fever. Use with caution if you have liver or kidney problems (it is contraindicated in severe liver impairment) or certain mental health disorders like schizophrenia, bipolar disorder, or psychosis. It is not recommended for patients with specific eye conditions, including albinism, retinal degeneration, uveitis, inherited retinopathy, or severe progressive diabetic retinopathy. XAFINACT 100MG TABLET may cause dizziness and sleepiness, or affect your vision, so avoid driving or operating heavy machinery until you know how the medicine affects you. It is also advisable to reduce or avoid a high-protein diet (e.g., meat, poultry, dairy products) as it may lead to an unsafe rise in blood pressure. Alcohol consumption should be avoided or limited as it can cause excessive drowsiness. Regular blood pressure monitoring is recommended.

What happens if a dose of XAFINACT 100MG TABLET is missed?

If you miss a dose of XAFINACT 100MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important not to skip any doses and to complete the full course of treatment as prescribed by your doctor, even if you start to feel better.

How should XAFINACT 100MG TABLET be stored?

XAFINACT 100MG TABLET should be stored at controlled room temperature, typically below 30°C or between 20°C to 25°C. Keep the medicine out of sight and reach of children and pets. It should be kept away from moisture, heat, and light, and should not be frozen.