Civono 20 Mg Tab

CIVONO 20 MG TAB

CIVONO 20 MG TAB by CIPLA HEALTH LTD. is a medication primarily used for managing various gastrointestinal disorders by reducing stomach acid production.

Name

• Brand Name: Civono 20 Tablet
• Common Name: Vonoprazan 20 mg Tablet

Composition

• Active Ingredient: Vonoprazan 20 mg
• Class: Potassium-competitive acid blocker (PCAB)

Uses Civono 20 Tablet is prescribed for:

• Reflux esophagitis, erosive esophagitis, and associated heartburn
• Gastric ulcers and duodenal ulcers
• Prevention of recurrence of gastric or duodenal ulcers, especially during the use of low-dose aspirin or NSAIDs
• Treatment of Helicobacter pylori infection, usually in combination with antibiotics like clarithromycin and/or amoxicillin
• Gastroesophageal reflux disease (GERD)

Dosage and Administration

• Typically taken once or twice daily, as directed by a doctor.
• Can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not break, crush, or chew it.
• For best results, try to take it at the same time each day.
• Avoid lying down immediately after taking the medication to prevent acid reflux.

Side Effects

• Common Side Effects: Diarrhea, bloating, stomach pain, nausea, indigestion, high blood pressure, and urinary tract infection. Stomach inflammation may also occur.
• Serious Side Effects (consult doctor): Kidney problems, Clostridioides difficile-associated diarrhea, bone fractures, severe skin reactions, low vitamin B12 levels, low magnesium levels, or fundic gland polyps (stomach growths).

Precautions

• Inform your doctor about any allergies to Civono 20 Tablet or its ingredients.
• Pregnancy and Breastfeeding: Consult your doctor before use, as information is limited or caution is advised.
• Alcohol: Avoid alcohol consumption as it may reduce the effectiveness of the medicine and delay ulcer healing.
• Drug Interactions: Inform your doctor about all other medications (including Rilpivirine, Nelfinavir, Atazanavir, iron salts, Ketoconazole) and herbal supplements you are taking, as interactions can occur.
• Medical Conditions: Discuss pre-existing conditions such as gastric malignancy, kidney or liver disease, bone issues, vitamin B12 deficiency, or low magnesium, calcium, or potassium levels with your doctor.
• Lifestyle: Avoid spicy, acidic, fatty foods, caffeine, and smoking. Maintaining a healthy weight and eating smaller, frequent meals can help.

Storage

• Store in a cool and dry place, protected from sunlight and moisture.
• Keep the medicine out of the sight and reach of children.
• Store below 30°C.

What is CIVONO 20 MG TAB used for?

CIVONO 20 MG TAB, containing Vonoprazan, is used to treat and manage various acid-related gastrointestinal conditions. This includes healing damage to the esophagus caused by excess stomach acid (erosive esophagitis), alleviating associated heartburn, treating gastric ulcers and duodenal ulcers. It is also prescribed in combination with antibiotics like clarithromycin and/or amoxicillin to eradicate Helicobacter pylori (H. pylori) infection, a common cause of stomach ulcers.

How does CIVONO 20 MG TAB work?

CIVONO 20 MG TAB works by reducing the amount of acid produced in the stomach. Its active ingredient, Vonoprazan, is a potassium-competitive acid blocker (P-CAB). It functions by inhibiting the H+/K+-ATPase enzyme, also known as the proton pump, in the stomach lining's parietal cells. This enzyme is responsible for the final step of acid production. By blocking this pump, Vonoprazan effectively reduces stomach acid secretion, helping to heal ulcers and relieve symptoms like heartburn and acid reflux. Unlike some other acid-reducing medications, Vonoprazan does not require stomach acid for activation and can accumulate in stomach cells regardless of their activity, binding to the proton pumps temporarily for effective action.

What is the usual dosage for CIVONO 20 MG TAB?

CIVONO 20 MG TAB is typically taken once daily, or as directed by your doctor. It can be taken with or without food. The tablet should be swallowed whole with a glass of water and should not be crushed or chewed. It is important to adhere to the prescribed dosage and complete the full course of treatment, even if symptoms improve.

What are the possible side effects of CIVONO 20 MG TAB?

Common side effects may include stomach inflammation, diarrhea, bloating, stomach pain, nausea, indigestion, high blood pressure, and urinary tract infection. These side effects are usually mild and temporary.

More serious, though less common, side effects can include kidney problems, Clostridioides difficile-associated diarrhea, bone fractures, severe skin reactions, low vitamin B12 levels, low magnesium levels, or fundic gland polyps (stomach growths). If you experience severe or persistent side effects, or any signs of serious reactions, consult your doctor immediately.

Is CIVONO 20 MG TAB safe during pregnancy or breastfeeding?

CIVONO 20 MG TAB is generally not recommended during pregnancy or while breastfeeding. Limited safety information is available for its use in pregnant women. If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to consult your doctor to assess the potential risks and benefits before taking this medication.

Can CIVONO 20 MG TAB be taken with other medications?

Yes, CIVONO 20 MG TAB can interact with certain medications. It is important to inform your doctor about all prescription, over-the-counter, herbal, and vitamin supplements you are currently taking to prevent potential drug interactions. Notable interactions include:

• Antiretrovirals such as rilpivirine, atazanavir, and nelfinavir, as Vonoprazan can reduce stomach acidity and potentially alter their absorption, affecting effectiveness and safety.
• CYP3A Substrates like verapamil or cyclosporine, as Vonoprazan weakly inhibits CYP3A enzymes, which might increase the concentration of these medications in the body.
• CYP2C19 Substrates such as clopidogrel, citalopram, and cilostazol, as Vonoprazan inhibits CYP2C19 enzymes, potentially altering their metabolism.
• Strong or Moderate CYP3A4 Inducers like phenytoin, which can reduce Vonoprazan exposure and potentially decrease its effectiveness.
• Iron salts, as Vonoprazan may reduce the absorption of iron.

What precautions should be taken while taking CIVONO 20 MG TAB?

Before taking CIVONO 20 MG TAB, inform your doctor if you have any allergies to its ingredients or other medications. Also, disclose any pre-existing medical conditions, especially liver or kidney disorders, osteopenia (bone mass loss), osteoporosis, or low levels of magnesium, calcium, or potassium in your blood. Caution is advised in patients with gastric malignancy, as Vonoprazan may mask its symptoms.

Avoid consuming alcohol and smoking while on this medication, as they can increase stomach acid production and worsen your condition or reduce the effectiveness of the tablet. It is also advisable to avoid spicy, fatty, and acidic foods that can trigger acid reflux. Do not lie down immediately after taking the medication to prevent acid reflux.

What happens if a dose of CIVONO 20 MG TAB is missed?

If you miss a dose of CIVONO 20 MG TAB, take it as soon as you remember, provided it is within 12 hours of the scheduled dose. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. If you are taking it for H. pylori infection, a missed dose should be taken within 4 hours.

How should CIVONO 20 MG TAB be stored?

CIVONO 20 MG TAB should be stored below 30ºC (86ºF). Keep it in a cool and dry place, protected from light and moisture. Always ensure the medicine is kept out of the sight and reach of children and pets. Do not use the medicine after its expiry date.