Consticalo- 2

CONSTICALO-2 by TORRENT PHARMA

• Name: CONSTICALO-2 (Brand Name).

• Composition: CONSTICALO-2 contains Prucalopride (2 mg) as its active ingredient. It is classified as a selective serotonin-4 (5-HT4) receptor agonist. Prucalopride works by stimulating the 5-HT4 receptors in the gastrointestinal tract, which enhances acetylcholine release and promotes peristalsis, thereby increasing gut motility and facilitating bowel movements.

• Uses: CONSTICALO-2 is primarily used for the management of chronic idiopathic constipation (CIC) in adults. It is prescribed when other laxatives have not provided adequate relief, helping to restore natural bowel movement, ease the passage of stools, and improve overall gut health and quality of life.

• Dosage and Administration: The typical recommended dosage for adults is 2 mg once daily. CONSTICALO-2 tablets can be taken orally with or without food, at any time of the day, swallowed whole without crushing or chewing. The exact dose and duration of treatment should be determined by a healthcare professional based on the individual's condition and response. It is crucial not to exceed the prescribed dosage.

• Side Effects: Common side effects may include headache, nausea, abdominal pain, decreased appetite, dizziness, dyspepsia (indigestion), and diarrhea. Most of these side effects are usually temporary and resolve with time. If side effects persist or worsen, medical consultation is advised.

• Precautions:

  • Allergies: Avoid taking CONSTICALO-2 if you are allergic to Prucalopride or any of its components.
  • Gastrointestinal Conditions: It is contraindicated in patients with intestinal obstruction, perforation, or severe inflammatory conditions of the intestinal tract such as Crohn's disease or ulcerative colitis.
  • Organ Impairment: Use with caution in patients with kidney or liver disease, as dose adjustments may be necessary.
  • Pregnancy and Breastfeeding: CONSTICALO-2 is not recommended during pregnancy; women of childbearing potential should use effective contraception during treatment. Breastfeeding is also not recommended while on this medication.
  • Driving and Machine Operation: CONSTICALO-2 may cause dizziness and tiredness, particularly at the beginning of treatment. Patients should avoid driving or operating heavy machinery until they know how the medicine affects them.
  • Children: The safety and efficacy of CONSTICALO-2 have not been established in children under 18 years of age, so its use is not recommended in this population.
  • Other Interactions: Alcohol consumption should be avoided. If severe diarrhea occurs, it may reduce the effectiveness of oral contraceptive pills. Mood changes and suicidal thoughts have been reported in some cases; report any such symptoms to your doctor.

• Storage: Store CONSTICALO-2 tablets at room temperature, ideally below 30°C. Keep the medicine away from direct sunlight, heat, and moisture. Always store it out of reach of children.

CONSTICALO-2 by TORRENT PHARMA is a medication used to treat chronic constipation in adults. Below are some frequently asked questions and their answers regarding this medicine.

What is CONSTICALO-2 used for?

CONSTICALO-2 (Prucalopride) is used to treat chronic idiopathic constipation in adults. This condition involves infrequent, difficult, or incomplete bowel movements without an identifiable cause, especially when other laxatives have not provided sufficient relief. It helps improve overall gut motility.

How does CONSTICALO-2 work?

CONSTICALO-2 contains prucalopride, which is a selective 5-HT4 receptor agonist. It works by stimulating the release of acetylcholine, a chemical messenger that increases intestinal motility and facilitates bowel movements. This action helps to restore the normal functioning of the bowel.

What is the usual dosage for CONSTICALO-2?

For adults, the typical recommended dose of CONSTICALO-2 is 2 mg once daily, taken with or without food. Your doctor may prescribe a lower dose of 1 mg once a day if you are over 65 years old or have severe kidney or liver disease. It is not recommended for individuals under 18 years of age.

What are the possible side effects of CONSTICALO-2?

Common side effects include headache, nausea, diarrhea, abdominal pain, decreased appetite, dizziness, and indigestion. Other possible side effects may include fatigue, abnormal bowel sounds, vomiting, and flatulence. These side effects are usually temporary and often resolve as your body adjusts to the medicine. If they persist or worsen, consult your doctor.

Is CONSTICALO-2 safe during pregnancy or breastfeeding?

CONSTICALO-2 is generally not recommended during pregnancy, and women of childbearing potential should use reliable contraception while taking this medication. If you become pregnant during treatment, inform your doctor immediately. Breastfeeding is also not recommended as prucalopride can pass into breast milk.

Can CONSTICALO-2 be taken with other medications?

CONSTICALO-2 can interact with other medications. Anticholinergic drugs (like atropine) may counteract its effects on gut motility. Antifungal medicines (such as ketoconazole) can increase the concentration of prucalopride in your body, potentially enhancing side effects. Combining it with serotonergic medicines (like SSRIs) may increase the risk of serotonin syndrome. If severe diarrhea occurs, oral contraceptive pills may become less effective, and additional contraceptive methods are advised. Always inform your doctor about all other medications you are taking.

What precautions should be taken while using CONSTICALO-2?

You should not take CONSTICALO-2 if you are allergic to prucalopride or any of its ingredients, are on renal dialysis, or suffer from conditions like gut wall perforation or obstruction, or severe inflammatory intestinal diseases (e.g., Crohn's disease, ulcerative colitis, toxic megacolon/megarectum). Caution is advised for individuals with kidney or liver disease, and your doctor may adjust the dose. It may cause dizziness and tiredness, especially on the first day, so be careful when driving or operating machinery. Stay well-hydrated, particularly if you experience diarrhea. Consult your doctor if your constipation does not improve after four weeks of treatment.

What happens if a dose of CONSTICALO-2 is missed?

If you miss a dose of CONSTICALO-2, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

How should CONSTICALO-2 be stored?

CONSTICALO-2 should be kept at room temperature, ideally below 30°C. It should be protected from direct sunlight and moisture. Always keep the medicine out of the reach and sight of children and pets.