Glura M Xr Forte Tablet (15 Tab)

GLURA M XR FORTE TABLET

GLURA M XR FORTE TABLET by ERIS LIFESCIENCES LIMITED is an extended-release oral antidiabetic medication. It is designed to help manage blood sugar levels in adults with type 2 diabetes mellitus.

Name

• Brand Name: GLURA M XR FORTE TABLET
• Common Name: Metformin and Sitagliptin Extended-Release Tablets

Composition

• Active Ingredients: Metformin and Sitagliptin. The "Forte" designation typically indicates a higher strength formulation, often 1000mg of Metformin and 100mg of Sitagliptin in this combination.
  • Metformin, a biguanide, works by decreasing glucose production in the liver, reducing intestinal glucose absorption, and improving the body's sensitivity to insulin.
  • Sitagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, increases the levels of certain natural substances that lower blood sugar when it is high. It stimulates the pancreas to release more insulin and decreases glucagon levels.

Uses GLURA M XR FORTE TABLET is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone are not sufficient to control blood sugar levels effectively, or when more than one oral antidiabetic medicine is required. This medication helps improve overall glycemic control, preventing serious complications of diabetes such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.

Dosage and Administration The dosage of GLURA M XR FORTE TABLET is determined by a healthcare professional based on the individual's condition, blood sugar levels, and response to treatment.

• It is typically taken orally, preferably with the evening meal to minimize stomach upset.
• The tablets should be swallowed whole with water and not crushed, chewed, or broken.
• Regular monitoring of blood sugar levels is crucial during treatment.

Side Effects Common side effects may include:

• Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
• Metallic taste
• Headache, sore throat, stuffy nose, and joint pain
• Hypoglycemia (low blood sugar), especially when taken with other diabetes medications like insulin or sulfonylureas.

Serious but rare side effects include:

• Lactic acidosis (symptoms include severe tiredness, difficulty breathing, stomach pain, muscle cramps, and feeling sick)
• Decreased vitamin B12 absorption with long-term use
• Allergic reactions (rash, itching, swelling)

Precautions

• Inform your doctor about any pre-existing health conditions, especially kidney, liver, or heart problems, pancreatitis, or low vitamin B12 levels.
• Not recommended for patients with severe, uncontrollable diabetes, type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver disease, congestive heart failure, alcoholism, shock, or problems with breathing or blood circulation.
• Caution is advised if you are pregnant, planning a pregnancy, or breastfeeding.
• Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis and hypoglycemia.
• Inform your doctor about all other medications, supplements, and herbal products being taken to avoid potential drug interactions (e.g., insulin, other antidiabetic medicines, diuretics, cationic medicines).
• Regular monitoring of blood sugar levels and kidney function is advised.

Storage

• Store at room temperature, ideally below 30°C.
• Keep in a cool, dry place, away from light and moisture.
• Ensure it is out of the sight and reach of children and pets.
• Do not use after the expiry date.

What is GLURA M XR FORTE TABLET used for?

GLURA M XR FORTE TABLET is used to treat Type 2 diabetes mellitus in adults. It helps control high blood sugar levels when diet and exercise alone are not sufficient. This medication aims to prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, and may reduce the risk of heart attack or stroke.

How does GLURA M XR FORTE TABLET work?

This medicine is a combination of two active ingredients: Sitagliptin and Metformin. Metformin works by reducing the amount of glucose (sugar) produced by the liver, decreasing the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin. Sitagliptin, a DPP-4 inhibitor, works by increasing the levels of natural substances called incretins, which help the pancreas produce more insulin when blood sugar levels are high and reduce the amount of sugar the liver makes. Together, these actions provide better control of blood sugar. The extended-release (XR) formulation allows for a sustained release of the medication, often permitting once-daily dosing.

What is the usual dosage for GLURA M XR FORTE TABLET?

The dosage of GLURA M XR FORTE TABLET is determined by your doctor based on your medical condition, blood sugar levels, and response to treatment. It should be taken exactly as prescribed. The tablet is typically swallowed whole with water, preferably with a meal (often the evening meal), and should not be crushed, split, or chewed.

What are the possible side effects of GLURA M XR FORTE TABLET?

Common side effects can include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, stomach pain, headache, upper respiratory tract infection, altered or metallic taste, and loss of appetite.

More serious, but rare, side effects include lactic acidosis (symptoms like muscle pain, dizziness, cold extremities, difficulty breathing, severe nausea, vomiting, and stomach pain) and Vitamin B12 deficiency with long-term use. If you experience any severe or persistent side effects, or symptoms of lactic acidosis, seek immediate medical attention.

Is GLURA M XR FORTE TABLET safe during pregnancy or breastfeeding?

GLURA M XR FORTE TABLET is generally not recommended for use during pregnancy and may be considered unsafe. Limited human studies are available, and animal studies have shown harmful effects on the developing baby.

Similarly, it is probably unsafe to use during breastfeeding as the drug may pass into breast milk and potentially harm the baby. It is crucial to consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can GLURA M XR FORTE TABLET be taken with other medications?

GLURA M XR FORTE TABLET can interact with other medicines. It's important to inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential interactions.

Specific interactions may occur with other antidiabetic medicines (increasing the risk of hypoglycemia), diuretics (like Furosemide, increasing the risk of lactic acidosis), certain cationic medicines (such as amiloride, digoxin, and ranitidine), beta-blockers, iodine contrast medium, corticosteroids, NSAIDs, and some antihypertensives.

What precautions should be taken while using GLURA M XR FORTE TABLET?

Avoid consuming alcohol while taking GLURA M XR FORTE TABLET as it can increase the risk of lactic acidosis and low blood sugar.

This medicine should be used with caution in patients with kidney disease, and is generally not recommended for severe kidney impairment or liver disease. It is not suitable for Type 1 diabetes, severe, uncontrollable diabetes, or in children under 18 years of age. Caution is advised for elderly patients. Inform your doctor if you have heart problems, pancreatitis, high blood cholesterol, severe infections, dehydration, or are scheduled for surgery. Regular monitoring of your blood sugar levels and kidney function is crucial during treatment.

What happens if a dose of GLURA M XR FORTE TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should GLURA M XR FORTE TABLET be stored?

Store GLURA M XR FORTE TABLET at room temperature, ideally below 30°C (or between 20-25°C). Keep it in its original container, tightly closed, in a dry place, and away from light and moisture. Always ensure the medicine is kept out of the reach of children and pets. Make sure to use the medication before its expiry date.