Zavamet 500 Tablet

ZAVAMET 500 TABLET

Name:

• Brand Name: ZAVAMET 500 TABLET
• Common Name: Vildagliptin and Metformin combination

Composition: ZAVAMET 500 TABLET is a fixed-dose combination medication. Each tablet contains:

• Vildagliptin: 50 mg
• Metformin Hydrochloride: 500 mg

Uses: ZAVAMET 500 TABLET is prescribed for the management of type 2 diabetes mellitus in adults. It is used when diet and exercise alone, or vildagliptin or metformin individually, are insufficient to control blood sugar levels. This medication helps to improve glycemic control and reduce the risk of diabetes-related complications such as kidney damage, eye damage, nerve problems, and cardiovascular issues.

Dosage and Administration: This medicine should be taken orally, typically twice daily, preferably with meals to minimize stomach upset. The tablet should be swallowed whole and not crushed, chewed, or broken. Dosage depends on the patient's condition, blood sugar levels, and other medications being taken, and should always be as advised by a doctor. It is crucial not to discontinue the medication without consulting a doctor.

Side Effects: Common Side Effects:

• Nausea, vomiting, stomach pain
• Diarrhea, constipation
• Headache, dizziness
• Low blood sugar (hypoglycemia), especially when used with insulin or sulfonylureas, or with inadequate calorie intake
• Loss of appetite, metallic taste
• Joint pain, tiredness
• Swollen hands, ankles, or feet (oedema)

Serious Side Effects:

• Lactic acidosis (rare but serious, symptoms include vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, severe tiredness)
• Symptoms of an inflamed pancreas (severe and persistent abdominal pain with or without nausea or vomiting)

Precautions:

• Contraindications: Avoid use if allergic to any components. Contraindicated in patients with severe kidney or liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis. Not recommended for type 1 diabetes mellitus or in children and adolescents under 18 years of age.
• Pregnancy and Breastfeeding: Not recommended for pregnant or breastfeeding women; consult a doctor for advice.
• Alcohol: Avoid alcohol consumption as it may increase the risk of lactic acidosis and low blood sugar.
• Driving: Use with caution as blood sugar fluctuations can affect driving ability.
• Interactions: Inform your doctor about all medicines and supplements you are taking. Regular monitoring of kidney function, liver enzymes, and blood sugar levels is essential.

Storage: Store in a cool and dry place, away from direct sunlight, at or below 30°C. Keep out of sight and reach of children. Store in the original container, securely sealed.

Here are some frequently asked questions about ZAVAMET 500 TABLET:

What is ZAVAMET 500 TABLET used for?

ZAVAMET 500 TABLET is a combination medicine primarily used to manage Type 2 Diabetes Mellitus in adults. It is prescribed when diet and exercise alone, or other single antidiabetic medicines, are not sufficient to control blood sugar levels. It helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.

How does ZAVAMET 500 TABLET work?

ZAVAMET 500 TABLET contains two active ingredients: Metformin and Vildagliptin. Metformin, a biguanide, works by lowering the production of glucose in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Vildagliptin, a DPP-4 inhibitor, works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels (glucagon). Together, they provide better control of blood sugar, reducing both fasting and post-meal sugar levels.

What is the usual dosage for ZAVAMET 500 TABLET?

ZAVAMET 500 TABLET is typically taken orally, usually twice daily with meals, or as directed by your doctor. It should be swallowed whole with water and not crushed, chewed, or broken. The exact dose and duration will depend on your medical condition, blood sugar levels, and response to treatment, as determined by your doctor.

What are the possible side effects of ZAVAMET 500 TABLET?

Common side effects of ZAVAMET 500 TABLET can include hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, hunger pangs, dry mouth, changes in taste, nausea, vomiting, diarrhea, stomach pain, headache, and upper respiratory symptoms. A rare but serious side effect called lactic acidosis (too much lactic acid in the blood) can occur, with symptoms like extreme tiredness, weakness, deep and rapid breathing, stomach pain, nausea, and vomiting. If you experience any severe or persistent side effects, contact your doctor immediately.

Is ZAVAMET 500 TABLET safe during pregnancy or breastfeeding?

ZAVAMET 500 TABLET is generally not recommended during pregnancy, as there is limited information about its safety, and animal studies have shown harmful effects on the developing baby. It is also probably unsafe to use during breastfeeding, as its components are known to pass into breast milk and may harm the baby. Always consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can ZAVAMET 500 TABLET be taken with other medications?

ZAVAMET 500 TABLET can interact with certain medications. Inform your doctor about all medicines and supplements you are taking. Critical interactions include those with metformin (one of the components) and certain imaging agents containing iodine (like iobitridol and iopamidol). Other medications that may interact include glucocorticoids (e.g., dexamethasone), beta-2 agonists (e.g., albuterol), diuretics (e.g., furosemide), NSAIDs (e.g., ibuprofen), ACE inhibitors (e.g., enalapril), sulfonylureas, insulin, and some medicines for heart problems and high blood pressure.

What precautions should be taken while taking ZAVAMET 500 TABLET?

Before taking ZAVAMET 500 TABLET, inform your doctor if you have liver, kidney, or heart problems, a history of pancreatitis, or low vitamin B12 levels. Avoid alcohol consumption, as it can dangerously lower blood sugar and increase the risk of lactic acidosis. Regular monitoring of blood sugar levels, kidney function, and liver enzymes is essential during treatment. Do not stop the medication abruptly without consulting your doctor, as this can lead to increased blood sugar levels and potential complications. It is not recommended for patients under 18 years of age.

What happens if a dose of ZAVAMET 500 TABLET is missed?

If you miss a dose of ZAVAMET 500 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one, as this may increase the risk of side effects.

How should ZAVAMET 500 TABLET be stored?

ZAVAMET 500 TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it in its original container, tightly closed, and out of sight and reach of children and pets. Do not use the medicine if it has passed its expiry date.