Macrabonic Plus

MACRABONIC PLUS by ERIS LIFESCIENCES LIMITED

MACRABONIC PLUS is a medication manufactured by Eris Lifesciences Limited, designed to address various gastrointestinal issues.

Composition MACRABONIC PLUS contains a combination of two active ingredients:

• Rabeprazole (40mg): A proton pump inhibitor (PPI) that reduces the production of stomach acid.
• Levosulpiride (75mg): A prokinetic agent that enhances gastrointestinal motility and prevents the backflow of food and acid.

Uses This medicine is prescribed for the treatment of several acid-related and motility-related gastrointestinal conditions, including:

• Gastro-oesophageal Reflux Disease (GERD)
• Acidity and heartburn
• Zollinger-Ellison syndrome
• Helicobacter pylori infection
• Irritable Bowel Syndrome (IBS), particularly with bloating and delayed gastric emptying
• Indigestion and functional dyspepsia
• Duodenal and gastric ulcers

Dosage and Administration MACRABONIC PLUS is typically taken orally once daily. It is generally recommended to take the capsule on an empty stomach, at least 30 minutes to one hour before a meal, for optimal absorption. The capsule should be swallowed whole with a glass of water; it should not be chewed, crushed, or broken. The specific dosage and duration of treatment are determined by a physician based on the patient's condition and response to the medicine.

Side Effects Common side effects may include:

• Headache, dizziness, sleepiness, nervousness
• Nausea, vomiting, stomach pain, diarrhea, constipation, bloating, gas, abdominal pain
• Weakness or flu-like symptoms

Less common or serious side effects can include:

• Abnormal movements of body parts, stiff and jerky movements
• Increased breast size, abnormal milk production (galactorrhea), and absence of periods in females
• Low blood pressure, allergic reactions (rash, itching, swelling, difficulty breathing), frequent infections, skin blisters and rashes, mouth ulcers
• Prolonged use may lead to bone thinning (osteoporosis) and low magnesium levels (hypomagnesemia).

Precautions

• Contraindications: Do not take MACRABONIC PLUS if you are allergic to its components, have a history of fits or epilepsy, mental disorders affecting walking/balance, pheochromocytoma, or breast cancer.
• Pregnancy and Breastfeeding: This medicine should generally be avoided during pregnancy and breastfeeding, as it may be unsafe. Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.
• Alcohol: Avoid alcohol consumption during treatment, as it can intensify side effects like confusion, drowsiness, and increase stomach acid production.
• Driving: As MACRABONIC PLUS may cause dizziness or drowsiness, avoid driving or operating heavy machinery if you experience these symptoms.
• Other Conditions: Inform your doctor about any history of kidney or liver problems, gastrointestinal bleeding or obstruction, brain tumor, heart disease, low vitamin B12 levels, or any other significant medical conditions.
• Drug Interactions: Inform your doctor about all other medications you are taking, including antifungals (Ketoconazole, Itraconazole), antivirals (Atazanavir), antacids (Sucralfate), antihypertensives, Methotrexate, Tacrolimus, and Warfarin, as interactions may occur.

Storage Store MACRABONIC PLUS below 30°C (some sources specify below 25°C or 10-25°C). Keep it in a cool, dry place, away from direct sunlight and moisture. Ensure the medicine is kept out of the reach of children.

What is MACRABONIC PLUS used for?

MACRABONIC PLUS is primarily used to treat various gastrointestinal conditions related to excess stomach acid. These include Gastroesophageal Reflux Disease (GERD), acidity, heartburn, and intestinal, peptic, or duodenal ulcers. It is also prescribed for Irritable Bowel Syndrome (IBS), Zollinger-Ellison syndrome, indigestion, stomach gas, and bloating.

How does MACRABONIC PLUS work?

MACRABONIC PLUS is a combination medication containing Rabeprazole and Levosulpiride. Rabeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach by blocking the gastric proton pump. Levosulpiride is a prokinetic agent that increases the movement (motility) of the stomach and intestines and strengthens the lower esophageal sphincter, which helps prevent acid and food from flowing back into the food pipe. This combined action helps alleviate acidity and heartburn.

What is the usual dosage for MACRABONIC PLUS?

MACRABONIC PLUS should be taken exactly as prescribed by your doctor. It is typically taken once daily, preferably in the morning, on an empty stomach, at least 30 minutes to one hour before a meal. The capsule should be swallowed whole with a glass of water and not chewed, crushed, or broken. Your doctor will determine the appropriate dose and duration of treatment based on your specific condition and response to the medicine.

What are the possible side effects of MACRABONIC PLUS?

Common side effects may include nausea, stomach pain, diarrhea, flatulence (gas), constipation, headache, dizziness, weakness, sleepiness, and flu-like symptoms. Some individuals may also experience vomiting or abdominal pain. Prolonged use can lead to more serious effects such as bone thinning (osteoporosis), low magnesium levels (hypomagnesemia), and increased prolactin levels, which can cause painful menstrual periods, abnormal milk production, or breast enlargement. If any side effects persist or worsen, consult your doctor promptly.

Is MACRABONIC PLUS safe during pregnancy or breastfeeding?

MACRABONIC PLUS is generally not recommended during pregnancy as its components might harm the unborn baby. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, it is crucial to consult your doctor. Similarly, this medicine should not be taken while breastfeeding. You should discuss the risks and benefits with your doctor if you are a nursing mother.

Can MACRABONIC PLUS be taken with other medications?

MACRABONIC PLUS can interact with certain other medications. It is important to inform your doctor about all prescription and over-the-counter medicines, supplements, and herbal products you are currently taking. For example, medicines used to neutralize gastric acids (like sucralfate) should be taken at least two hours apart. It may interact with antifungals (e.g., ketoconazole, itraconazole), certain HIV medications (atazanavir), blood thinners (warfarin), and methotrexate. Combining it with antihypertensive medicines may lead to a drop in blood pressure.

What precautions should be taken while using MACRABONIC PLUS?

Avoid consuming alcohol while taking MACRABONIC PLUS, as it can worsen drowsiness and increase stomach acid production, potentially leading to stomach damage. Do not drive or operate heavy machinery if you experience dizziness, drowsiness, or reduced alertness. Inform your doctor if you have a history of liver or kidney disease, fits/epilepsy, mental disorders, heart conditions, or gastrointestinal bleeding or obstruction. Long-term use of this medicine may increase the risk of bone fractures and low magnesium levels; your doctor may recommend calcium and vitamin D supplements. This medicine is not recommended for children and adolescents under 18 years of age.

What happens if a dose of MACRABONIC PLUS is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should MACRABONIC PLUS be stored?

Store MACRABONIC PLUS below 30°C (or 25°C) in a cool and dry place, away from direct sunlight and moisture. Keep it in a tightly closed container and out of the reach and sight of children.