Pangraf 1.0 Mg Capsule (10 Cap)

PANGRAF 1.0 MG CAPSULE is an immunosuppressant medication, manufactured by Mankind Pharma Ltd., primarily used to prevent organ rejection in transplant recipients.

Name

• Brand Name: Pangraf 1.0 MG Capsule
• Common Name: Tacrolimus

Composition

Each hard gelatin capsule contains Tacrolimus IP 1.0 mg as the active ingredient.

Uses

PANGRAF 1.0 MG CAPSULE is prescribed to prevent organ rejection in patients who have received an allogenic kidney, liver, or heart transplant. It works by weakening the body's immune system, preventing it from attacking the new organ.

Dosage and Administration

The dosage of PANGRAF 1.0 MG CAPSULE is individualized and determined by a doctor based on the patient's condition and response. It is generally recommended to take the capsules on an empty stomach, at least one hour before or two to three hours after a meal, with water. The daily dose is typically administered in two divided doses. Capsules should be swallowed whole and not chewed or broken.

Side Effects

Common side effects include tremor, headache, insomnia, nausea, vomiting, diarrhea, abdominal pain, hypertension (high blood pressure), and peripheral edema. More serious side effects can include kidney damage, increased blood sugar levels (hyperglycemia), hyperkalemia, and an increased risk of infections, lymphoma, and skin cancer.

Precautions

PANGRAF 1.0 MG CAPSULE should be used with caution in patients with kidney, liver, or heart problems, diabetes, or high blood pressure. It is unsafe to consume alcohol with this medicine, as it may increase adverse effects. Patients should avoid live vaccinations and limit exposure to sunlight and UV light due to an increased risk of skin malignancies. Inform your doctor if you are pregnant, breastfeeding, or taking other medications, including herbal preparations like St. John's wort. This medicine may cause visual or neurological disturbances, so caution is advised when driving or operating machinery.

Storage

Store PANGRAF 1.0 MG CAPSULE at room temperature, ideally below 25°C or 30°C. Keep the medicine protected from light and moisture, and out of reach of children.

PANGRAF 1.0 MG CAPSULE (containing Tacrolimus) is an immunosuppressant medicine primarily used to prevent organ rejection in patients who have undergone a transplant (e.g., liver, kidney, or heart). It works by weakening the body's immune system to stop it from attacking the transplanted organ.

Here are some frequently asked questions about PANGRAF 1.0 MG CAPSULE:

What is Pangraf 1.0 MG Capsule used for?

Pangraf 1.0 MG Capsule is primarily used to prevent the rejection of transplanted organs, such as the liver, kidney, or heart, by the body's immune system. It is an immunosuppressant that helps the body accept the new organ.

How does Pangraf 1.0 MG Capsule work?

Pangraf 1.0 MG Capsule contains Tacrolimus, which is a calcineurin inhibitor. It works by suppressing the activity of the immune system, specifically by inhibiting T-lymphocyte activation and proliferation. This reduces the body's immune response, preventing it from attacking and rejecting the transplanted organ.

What is the usual dosage for Pangraf 1.0 MG Capsule?

The dosage of Pangraf 1.0 MG Capsule is determined by your doctor based on the type of transplant, your body weight, and your individual response to the medication. It is typically taken twice daily, usually on an empty stomach, at least one hour before or two to three hours after a meal, to ensure maximal absorption. It's crucial to follow your doctor's instructions precisely and never alter the dosage without consultation.

What are the possible side effects of Pangraf 1.0 MG Capsule?

Common side effects can include tremor, headache, insomnia, nausea, vomiting, diarrhea, abdominal pain, high blood pressure (hypertension), and increased blood sugar levels (hyperglycemia). More serious side effects can involve kidney damage, infections, high potassium levels (hyperkalemia), and an increased risk of certain cancers. It's important to report any persistent or worsening side effects to your doctor.

Is Pangraf 1.0 MG Capsule safe during pregnancy or breastfeeding?

Pangraf 1.0 MG Capsule is generally not recommended during pregnancy as it may cause harm to the unborn baby. It also passes into breast milk and may be harmful to a nursing infant, so breastfeeding is generally advised against while taking this medicine. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Pangraf 1.0 MG Capsule be taken with other medications?

Pangraf 1.0 MG Capsule can interact with several medications. For instance, antifungals (like ketoconazole, itraconazole) can increase its levels in the blood, while anticonvulsants (like phenytoin, carbamazepine) can reduce them. Other medications such as certain antibiotics, antivirals, anti-HIV drugs, and some heart or blood pressure medications can also interact. It's crucial to inform your doctor about all medicines, herbal preparations (especially St. John's wort), and supplements you are taking to avoid potential interactions.

What precautions should be taken while taking Pangraf 1.0 MG Capsule?

Avoid consuming grapefruit or grapefruit juice, as it can increase the levels of tacrolimus in your blood. Alcohol consumption should also be avoided as it may aggravate side effects like visual and neurological disturbances. Regular monitoring of blood pressure, blood sugar, and kidney function is essential. Due to its immunosuppressive nature, you may be more susceptible to infections and have an increased risk of skin cancer; therefore, avoid excessive sun exposure and use protective clothing and sunscreen. Live vaccines should generally be avoided.

What happens if a dose of Pangraf 1.0 MG Capsule is missed?

If you miss a dose of Pangraf 1.0 MG Capsule, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one. Always consult your doctor if you have any doubts.

How should Pangraf 1.0 MG Capsule be stored?

Pangraf 1.0 MG Capsule should be stored at room temperature, ideally below 25°C or below 30°C, and protected from light and moisture. Keep the medicine out of the sight and reach of children and pets. Ensure it is used before the expiry date printed on the packaging.