Vymada 200 (box)

VYMADA 200

Name

VYMADA 200 (Box) is the brand name for a medicine manufactured by Novartis India Limited. Its common name is Vymada 200mg Tablet.

Composition

Each Vymada 200mg Tablet contains two active ingredients:

• Sacubitril: 97 mg
• Valsartan: 103 mg

Uses

VYMADA 200 is primarily used to manage symptomatic chronic heart failure with reduced ejection fraction (HFrEF) in adults. It helps reduce the risk of cardiovascular death and hospitalisation due to heart failure by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body.

Dosage and Administration

Vymada 200mg Tablet is taken orally, typically with or without food. It is recommended to take the tablet at the same time each day for maximum benefit. The tablets should be swallowed whole and not chewed, crushed, or broken. The recommended target dose is usually 200 mg twice daily, though the starting dose can vary (e.g., 50 mg or 100 mg twice daily) and is adjusted by a doctor based on patient response and other factors.

Side Effects

Common side effects may include:

• Hypotension (low blood pressure)
• Hyperkalaemia (high potassium levels in the blood)
• Cough
• Dizziness
• Renal impairment/renal failure (decreased kidney function) Other possible side effects include nausea, diarrhoea, headache, fatigue, stomach pain, and weakness. Serious side effects like angioedema can also occur.

Precautions

• Contraindications: Vymada 200mg Tablet should not be taken if there is a history of angioedema (swelling of face, lips, tongue, or throat) related to previous ACE inhibitor or ARB therapy. It is contraindicated in severe liver impairment, pregnancy, and breastfeeding. Do not start Vymada within 36 hours of discontinuing an ACE inhibitor. Concomitant use with aliskiren is contraindicated in diabetic patients.
• Warnings: Caution is advised in patients with kidney problems, low sodium levels, and dehydration. It may cause dizziness, affecting the ability to drive or operate heavy machinery. Regular monitoring of blood pressure, kidney function, and potassium levels is recommended during treatment. Avoid potassium supplements and potassium-rich foods.
• Alcohol: Caution is advised as alcohol consumption can increase dizziness.

Storage

Store Vymada 200mg Tablet at room temperature, ideally below 30°C. Keep it in the original packaging to protect it from moisture and out of the sight and reach of children.

Here are frequently asked questions about VYMADA 200 (Sacubitril/Valsartan), a medication manufactured by NOVARTIS INDIA LIMITED, along with concise answers:

What is VYMADA 200 used for?

VYMADA 200 mg Tablet is primarily used to manage symptomatic chronic heart failure with reduced ejection fraction (HFrEF) in adults. It helps improve heart function, reduce symptoms like breathlessness and fatigue, and lower the risk of cardiovascular death and hospitalization due to heart failure.

How does VYMADA 200 work?

VYMADA 200 is a combination medicine containing sacubitril and valsartan, an angiotensin receptor neprilysin inhibitor (ARNI). Sacubitril inhibits the enzyme neprilysin, which helps increase beneficial peptides that relax blood vessels, excrete sodium, and increase urination. Valsartan blocks angiotensin II type-1 (AT1) receptors, preventing the constriction of blood vessels and reducing water and salt retention. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood throughout the body.

What is the usual dosage for VYMADA 200?

The usual recommended target dose is 200 mg twice daily. Patients typically start with a lower dose, such as 50 mg or 100 mg twice daily, which is then gradually increased by the doctor every 2-4 weeks based on the patient's response and tolerance, until the target dose is achieved. VYMADA 200 mg tablets can be taken with or without food.

What are the possible side effects of VYMADA 200?

Common side effects of VYMADA 200 mg Tablet include low blood pressure (hypotension), dizziness, cough, and increased potassium levels in the blood (hyperkalemia). Other potential side effects may include nausea, diarrhea, stomach pain, headache, and impaired kidney function. If severe or persistent side effects occur, it is important to consult a doctor.

Is VYMADA 200 safe during pregnancy or breastfeeding?

No, VYMADA 200 mg Tablet is generally considered unsafe during pregnancy and is contraindicated. It may cause harm to the unborn baby. Breastfeeding women should also avoid using VYMADA 200 mg Tablet, as it is probably unsafe and the medicine may pass into breast milk and harm the baby.

Can VYMADA 200 be taken with other medications?

VYMADA 200 interacts with several medications. It should not be taken with ACE inhibitors; a gap of at least 36 hours is required before starting or stopping either medication. Concomitant use with aliskiren is also contraindicated, especially in diabetic patients or those with impaired kidney function. Other interacting medications include potassium-sparing diuretics (like spironolactone), NSAIDs (like ibuprofen), and lithium, which can increase the risk of side effects such as hyperkalemia or kidney problems. Always inform your doctor about all medicines, herbal preparations, and supplements you are currently taking.

What precautions should be taken with VYMADA 200?

Patients with a history of angioedema related to ACE inhibitor or ARB therapy, severe liver disease, or those with diabetes using aliskiren should not take VYMADA 200 mg Tablet. Regular monitoring of blood pressure, kidney function, and potassium levels is advised during treatment. It can cause dizziness, so caution is advised when driving or operating machinery. A low-salt diet and regular, gentle exercise can complement the treatment.

What happens if a dose of VYMADA 200 is missed?

If you miss a dose of VYMADA 200 mg Tablet, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the forgotten tablet.

How should VYMADA 200 be stored?

VYMADA 200 mg Tablet should be stored at room temperature, ideally below 30°C. Keep it in its original packaging to protect it from moisture and out of reach of children. Always use the medicine before its expiration date.