Bladmir S 50

BLADMIR S 50 is a medication manufactured by Alembic Pharmaceuticals Limited, primarily used for the management of overactive bladder (OAB) symptoms.

Name

• Brand Name: BLADMIR S 50 (also known as Bladmir-S 50 Tablet ER, Bladmir S 50 Tablet, Bladmir S 50 Combikit)

Composition

• Active Ingredients: Each tablet contains Mirabegron 50 mg and Solifenacin 5 mg.

Uses

BLADMIR S 50 is prescribed to manage the symptoms of an overactive bladder in adults. These symptoms include:

• Sudden urge to pass urine (urinary urgency)
• Increased frequency of passing urine
• Inability to control urine (urge incontinence or urine leakage)
• Increased night-time urination
• Dysuria (painful or difficult urination) It works by relaxing the bladder muscles, which increases the bladder's capacity and reduces involuntary contractions, thereby helping to control urination.

Dosage and Administration

• BLADMIR S 50 should be taken orally as directed by your doctor, usually once daily with a glass of water.
• It can be taken with or without food.
• Swallow the tablet whole; do not chew, crush, or divide it.
• It is advisable to take the medicine at the same time each day for optimal benefits.
• Do not exceed the prescribed dosage or stop taking the medicine without consulting your doctor.

Side Effects

Common side effects may include:

• Dry mouth
• Blurred vision
• Headache
• Dizziness
• Constipation
• Nausea, abdominal fullness, stomach pain, burping, heartburn
• Increased heart rate (fast heart rate)
• Urinary tract infection (UTI)
• High blood pressure (hypertension)
• Nasopharyngitis (inflammation of the nose and throat)
• Vomiting
• Retrograde ejaculation (in men)

If any of these side effects worsen or persist, consult your doctor.

Precautions

• Pregnancy: BLADMIR S 50 is not recommended during pregnancy unless considered necessary by a physician.
• Breastfeeding: The medicine is generally not recommended for breastfeeding women as it may pass into breast milk.
• Children: It is not suitable for use in children aged below 18 years.
• Medical Conditions: Inform your doctor if you have liver, kidney, or heart problems (including uncontrolled high blood pressure, heart failure, or abnormal heart rhythm), glaucoma, urinary retention, severe bowel problems (like toxic megacolon or gastric retention), myasthenia gravis, ulcerative colitis, or any bladder problems that obstruct urine flow.
• Allergies: Do not take BLADMIR S 50 if you are allergic to Mirabegron, Solifenacin, or any other ingredients in the medicine.
• Alcohol: Limit or avoid alcohol consumption as it may increase side effects such as dizziness and drowsiness.
• Driving and Operating Machinery: BLADMIR S 50 may cause blurred vision or dizziness; exercise caution when driving or operating machinery.
• Drug Interactions: Inform your doctor about all medicines you are taking, including herbal supplements. Potential interactions exist with medicines for fungal infections (e.g., ketoconazole), viral infections (e.g., ritonavir), high blood pressure (e.g., verapamil), other anticholinergic medicines (e.g., ipratropium), and certain antidepressants and antihistamines.

Storage

• Store BLADMIR S 50 in a cool, dry place, ideally between 20°C and 25°C.
• Protect from excessive heat, moisture, and light.
• Keep all medicines out of the reach and sight of children.

BLADMIR S 50 is a combination medication containing Mirabegron (50mg) and Solifenacin (5mg), used to treat symptoms of an overactive bladder.

What is BLADMIR S 50 used for?

BLADMIR S 50 is prescribed to treat symptoms associated with an overactive bladder (OAB). These symptoms can include frequent urination, an urgent and uncontrollable need to urinate, urinary incontinence (loss of bladder control), increased urination at night, and sometimes painful or difficult urination (dysuria).

How does BLADMIR S 50 work?

This medicine combines two active ingredients: Mirabegron and Solifenacin. Mirabegron is a beta-3 adrenergic receptor agonist that works by relaxing the detrusor muscle in the bladder as it stores urine, increasing its capacity and reducing involuntary contractions. Solifenacin is an antimuscarinic (anticholinergic) that blocks specific receptors (primarily M3) in the bladder muscles, further relaxing them and decreasing the urge and frequency of urination. Together, they help to control bladder function and reduce OAB symptoms.

What is the usual dosage of BLADMIR S 50?

The typical dosage for BLADMIR S 50 Tablet ER is one tablet taken once daily. It can be taken with or without food, but it's often recommended to take it at the same time each day to maintain consistent medication levels in your body. Always follow your doctor's prescribed dose and duration.

What are the possible side effects of BLADMIR S 50?

Common side effects can include dry mouth, constipation, blurred vision, urinary tract infection, headache, dizziness, drowsiness, nausea, stomach pain, and dry eyes.

Serious side effects are less common but require immediate medical attention. These may include severe allergic reactions (e.g., rash, swelling of the face, lips, tongue, or throat, difficulty breathing), inability to empty the bladder (urinary retention), severe stomach pain or constipation lasting more than three days, symptoms of heat exhaustion or heat stroke, or irregular/fast heartbeat.

Is BLADMIR S 50 safe during pregnancy or breastfeeding?

Pregnancy: BLADMIR S 50 is generally not recommended during pregnancy because there isn't enough information to confirm its safety for an unborn baby. If you are pregnant or planning to become pregnant, discuss this with your doctor to determine if the benefits outweigh the potential risks.

Breastfeeding: It is unknown how much of BLADMIR S 50 passes into breast milk. An alternative medication might be preferred, especially for newborns or premature infants, due to the drug's long half-life. Long-term use could potentially reduce milk production. Monitor the infant for any signs of decreased milk intake or anticholinergic effects like constipation. Consult your doctor or pharmacist if you are breastfeeding.

Can BLADMIR S 50 be taken with other medications?

BLADMIR S 50 can interact with certain other medications. For example, co-administration with strong CYP3A4 inhibitors (like ketoconazole) can increase the levels of Solifenacin in your body, and your doctor may need to adjust the dose, typically not exceeding 25 mg Mirabegron / 5 mg Solifenacin per day. It can also interact with drugs metabolized by CYP2D6 (e.g., thioridazine, flecainide) and medications that prolong the QT interval. Always inform your doctor about all prescription and over-the-counter medicines, vitamins, and herbal products you are taking.

What precautions should be taken while using BLADMIR S 50?

Do not take BLADMIR S 50 if you have an allergy to its ingredients, urinary retention (inability to empty your bladder), gastric retention (slow emptying of your stomach), or uncontrolled narrow-angle glaucoma.

Use with caution if you have a history of heart rhythm problems (QT prolongation), severe kidney or liver disease, stomach or bowel problems (especially severe constipation), or bladder outlet obstruction. This medicine may cause dizziness, drowsiness, or blurred vision, so avoid driving or operating heavy machinery until you know how it affects you. It may also reduce your body's ability to sweat, increasing the risk of heat stroke; avoid extreme heat exposure. Discuss grapefruit juice and alcohol consumption with your doctor, as they may increase side effects.

What happens if a dose of BLADMIR S 50 is missed?

If you miss a dose of BLADMIR S 50, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule the next day. Do not take a double dose to make up for a missed one.

How should BLADMIR S 50 be stored?

Store BLADMIR S 50 tablets at room temperature, typically between 68°F to 77°F (20°C to 25°C). Keep it away from heat, moisture, and direct light. Temporary exposure to temperatures between 59°F and 86°F (15°C and 30°C) is acceptable. If you have the oral suspension, store it in its original bottle and discard any unused medicine 28 days after opening.