AZMARDA 200 MG TABLET is a prescription medicine manufactured by J.B. Chemicals & Pharmaceuticals Ltd..

Name

• Brand Name: AZMARDA 200 MG TABLET
• Common Name: Sacubitril/Valsartan

Composition

Each AZMARDA 200 MG TABLET contains a combination of two active ingredients:

• Sacubitril: 97 mg
• Valsartan: 103 mg

This combination belongs to a class of medications known as Angiotensin Receptor-Neprilysin Inhibitors (ARNIs).

Uses

AZMARDA 200 MG TABLET is primarily used to treat:

• Heart Failure: Specifically, chronic heart failure with reduced ejection fraction (HFrEF) in adults, helping to reduce the risk of cardiovascular death and hospitalization. It aids the heart in pumping blood more efficiently by relaxing and widening blood vessels.
• Hypertension Management: It may also be used to manage hypertension (high blood pressure), reducing the risk of heart-related issues.

Dosage and Administration

AZMARDA 200 MG TABLET should be taken exactly as prescribed by a physician.

• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It can be taken with or without food.
• It is often recommended to take it at the same time each day for maximum benefit and to maintain consistent levels in the body.
• Do not exceed the recommended dose or stop taking the medicine without consulting your doctor.

Side Effects

Common side effects may include:

• Dizziness, light-headedness (due to low blood pressure)
• Cough
• Nausea, diarrhea, stomach pain
• Headache, tiredness, weakness
• Increased potassium levels in the blood (hyperkalemia)
• Impaired renal function

Serious side effects, though rare, may include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat). Seek immediate medical attention if these occur.

Precautions

• Allergies: Do not take if allergic to sacubitril, valsartan, or any components of the medicine.
• Pregnancy and Breastfeeding: Contraindicated in pregnant and breastfeeding women due to potential harm to the baby.
• Kidney/Liver Disease: Use with caution in patients with kidney or liver diseases. Regular monitoring of kidney function may be required. Not recommended for severe liver disease.
• Low Blood Pressure: May cause orthostatic hypotension; rise slowly from sitting or lying positions.
• Potassium Levels: Avoid potassium supplements and potassium-rich foods unless advised by a doctor, as it can increase blood potassium levels.
• Drug Interactions: Inform your doctor about all medications, especially other heart or blood pressure medications (e.g., ACE inhibitors like Ramipril, aliskiren), lithium, and potassium-containing supplements, as interactions can occur. Do not take within 36 hours of taking an ACE inhibitor.
• Driving: May cause dizziness or tiredness; exercise caution while driving or operating machinery.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Maintain at room temperature, ideally not exceeding 30°C.
• Keep out of the sight and reach of children.
• Store in the original package to protect from moisture.

AZMARDA 200 MG TABLET (7 TAB) FAQs

What is Azmarda 200 mg Tablet used for?

Azmarda 200 mg Tablet is primarily used to treat heart failure in adults, particularly chronic heart failure with reduced ejection fraction (HFrEF). It helps reduce the risk of hospitalization and death in affected individuals. It may also be used to manage hypertension (high blood pressure) and provide cardiovascular protection. This medication is also indicated for symptomatic heart failure in pediatric patients aged one year and older.

How does Azmarda 200 mg Tablet work?

Azmarda 200 mg Tablet is a combination of two active ingredients: sacubitril and valsartan, belonging to a class of medications called Angiotensin Receptor-Neprilysin Inhibitors (ARNI). Sacubitril works by increasing the levels of certain beneficial peptides in the body that relax and widen blood vessels, enhance sodium excretion, and reduce strain on the heart. Valsartan, an angiotensin receptor blocker (ARB), relaxes blood vessels by blocking the effects of angiotensin II, a hormone that causes blood vessels to constrict. Together, these actions make it easier for the heart to pump blood throughout the body, improving heart function and reducing blood pressure.

What is the usual dosage of Azmarda 200 mg Tablet?

Your doctor will determine the appropriate dose and duration of treatment based on your medical condition and response to the medicine. It is crucial to take Azmarda 200 mg Tablet exactly as prescribed by your physician. The tablet should be swallowed whole with water and can be taken with or without food. It is often recommended to take it at the same time each day to help maintain consistent levels in your body. Never alter the prescribed dosage or stop taking the medicine without consulting your doctor. For pediatric patients weighing over 50 kg, the recommended dose is Sacubitril 97 mg/Valsartan 103 mg twice daily.

What are the possible side effects of Azmarda 200 mg Tablet?

Common side effects may include cough, dizziness, nausea, diarrhea, weakness, and low blood pressure (hypotension). Other reported side effects include headache, stomach pain, impaired kidney function, and high potassium levels in the blood (hyperkalemia). If you experience severe or persistent side effects, or notice swelling of the face, lips, tongue, or throat, consult your doctor immediately.

Is Azmarda 200 mg Tablet safe during pregnancy or breastfeeding?

No, Azmarda 200 mg Tablet is not recommended during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. It is also contraindicated for breastfeeding women, as it may pass into breast milk. If you are pregnant, planning to conceive, or breastfeeding, you must consult your doctor before taking this medicine.

Can Azmarda 200 mg Tablet be taken with other medications?

Azmarda 200 mg Tablet can interact with other medications, potentially increasing the risk of side effects or reducing effectiveness. It should not be taken with ACE inhibitors (like enalapril or captopril), and there should be a gap of at least 36 hours before or after taking an ACE inhibitor. Co-administration with aliskiren (a medication for high blood pressure) is also not recommended, particularly in patients with diabetes or kidney disease. Caution is advised when used with potassium-sparing diuretics (e.g., spironolactone, amiloride), NSAIDs (e.g., ibuprofen), and potassium supplements, as these can increase potassium levels or affect kidney function. Always inform your doctor about all prescription, over-the-counter, herbal, and vitamin supplements you are currently taking.

What precautions should be taken?

Inform your doctor if you have kidney or liver diseases, diabetes, low blood pressure, or a history of angioedema (swelling of the face, lips, tongue, or throat). This medicine may cause dizziness or tiredness, so avoid driving or operating heavy machinery until you know how it affects you. To avoid dizziness upon standing, get up slowly from a sitting or lying position. Regular monitoring of blood pressure, kidney function, and potassium levels is often advised during treatment. Avoid consuming potassium-rich foods or potassium-containing salt substitutes without consulting your doctor, as this can lead to high potassium levels. Alcohol consumption should be approached with caution as it may enhance blood pressure-lowering effects.

What happens if a dose is missed?

If you miss a dose of Azmarda 200 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten tablet.

How should Azmarda 200 mg Tablet be stored?

Azmarda 200 mg Tablet should be stored at room temperature, ideally not exceeding 30°C. Keep it in its original package to protect it from direct sunlight, heat, moisture, and dampness. Ensure the medicine is kept out of the sight and reach of children and pets. Always check the expiry date and use the medicine before it expires.