Advog M 0.2 Plus

ADVOG M 0.2 PLUS Tablet

ADVOG M 0.2 PLUS Tablet, manufactured by Eris Lifesciences Limited, is a combination medication used for the management of type 2 diabetes mellitus in adults.

Composition Each tablet of ADVOG M 0.2 PLUS contains two active ingredients:

• Voglibose (0.2 mg): An alpha-glucosidase inhibitor that delays the breakdown and absorption of carbohydrates in the intestine, thereby preventing a sudden rise in blood sugar levels after meals.
• Metformin (500 mg): A biguanide that reduces glucose production by the liver, decreases glucose absorption from the intestines, and enhances the body's sensitivity to insulin, increasing peripheral glucose uptake and utilization.

Uses ADVOG M 0.2 PLUS Tablet is prescribed for:

• Controlling high blood sugar levels in adults with type 2 diabetes mellitus, especially when diet, exercise, and single-agent antidiabetic medicines are insufficient.
• Reducing the risk of cardiovascular complications in diabetic patients who already have heart disease.
• Assisting in maintaining a healthy lifestyle when complemented with regular exercise and a balanced diet.
• Helping to control post-meal high blood sugar levels.

Dosage and Administration ADVOG M 0.2 PLUS Tablet should be taken as directed by a doctor. It is typically consumed orally, often just before or with meals, particularly the first main meal of the day, to reduce the risk of gastrointestinal upset and optimize post-meal blood sugar control. Tablets should be swallowed whole with water, without crushing or chewing. Consistent daily timing is recommended for optimal benefits, and the prescribed dosage should not be exceeded. Regular blood sugar monitoring is crucial during treatment.

Side Effects Common side effects may include:

• Diarrhea
• Abdominal pain
• Nausea and vomiting
• Decreased appetite
• Metallic taste in the mouth
• Skin rash
• Flatulence
• Headache and dizziness

Serious, though rare, side effects include lactic acidosis, which presents with symptoms like muscle pain, difficulty breathing, and weakness. Hypoglycemia (low blood sugar) can occur, especially when used with other antidiabetic medicines or alcohol, or if meals are missed.

Precautions

• Allergy: Do not take if allergic to metformin, voglibose, or any other components of the tablet.
• Kidney/Liver Conditions: Caution is advised in patients with kidney or liver disease. It is contraindicated in severe renal impairment and acute/chronic metabolic acidosis.
• Alcohol: Excessive alcohol consumption should be avoided as it can increase the risk of lactic acidosis.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding due to limited safety data; consult a doctor.
• Drug Interactions: Inform your doctor about all medicines, supplements, or herbal products being taken, as interactions can occur with carbonic anhydrase inhibitors, cationic medicines, certain asthma medications, and diuretics, among others.
• Other Conditions: Contraindicated in patients with type 1 diabetes, diabetic ketoacidosis, cirrhosis, inflammatory bowel disease, colonic ulceration, or intestinal obstruction. Use with caution in older patients.

Storage Store in a cool and dry place, away from direct sunlight and moisture. Keep out of the sight and reach of children. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

Here are some frequently asked questions about ADVOG M 0.2 PLUS:

What is ADVOG M 0.2 PLUS used for?

ADVOG M 0.2 PLUS is a combination medicine primarily used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet, exercise, and a single diabetes medicine are not sufficient. Managing blood sugar is crucial to prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. It may also reduce the risk of cardiovascular disease in patients with type 2 diabetes and existing cardiovascular disease.

How does ADVOG M 0.2 PLUS work?

ADVOG M 0.2 PLUS contains two active ingredients: Metformin and Voglibose. Metformin works by reducing glucose production in the liver, slowing the absorption of glucose from the intestines, and improving the body's sensitivity to insulin. Voglibose is an alpha-glucosidase inhibitor that delays the digestion and absorption of carbohydrates in the intestine, thereby preventing a rapid rise in blood glucose levels after a meal. Together, they help to maintain stable blood sugar levels.

What is the usual dosage of ADVOG M 0.2 PLUS?

ADVOG M 0.2 PLUS should be taken exactly as prescribed by your doctor. It is typically taken orally, usually with or after a meal to help prevent nausea and abdominal discomfort. For optimal results, it should be taken consistently at the same time each day. Do not crush or chew the tablet, swallow it whole with a glass of water. Your doctor will determine the appropriate dose based on your health condition and response to the medication.

What are the possible side effects of ADVOG M 0.2 PLUS?

Common side effects of ADVOG M 0.2 PLUS can include diarrhea, nausea, vomiting, gas, indigestion, abdominal pain, headaches, decreased appetite, and changes in taste. Some individuals might also experience hypoglycemia (low blood sugar) when taking this medication in combination with other antidiabetic drugs, consuming alcohol, or missing meals. A rare but serious side effect is lactic acidosis, which requires immediate medical attention if symptoms like muscle pain, breathing difficulty, or weakness occur.

Is ADVOG M 0.2 PLUS safe during pregnancy or breastfeeding?

ADVOG M 0.2 PLUS is generally not recommended during pregnancy or breastfeeding due to limited information regarding its safety. Animal studies have indicated that metformin/voglibose may pass through breast milk and can impact carbohydrate absorption in the nursing offspring. It is important to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Can ADVOG M 0.2 PLUS be taken with other medications?

ADVOG M 0.2 PLUS can interact with other medicines, supplements, or herbal preparations. It's crucial to inform your doctor about all medications you are currently taking. Some medications that may interact include those used to reduce pain and swelling (like ibuprofen, celecoxib), asthma medications (like salbutamol, terbutaline), diuretics (like furosemide), carbonic anhydrase inhibitors (like topiramate, zonisamide), and certain cationic medicines (like amiloride, digoxin). Alcohol consumption should be avoided or limited as it can increase the risk of lactic acidosis.

What precautions should be taken while taking ADVOG M 0.2 PLUS?

Several precautions should be taken while on ADVOG M 0.2 PLUS. It is not suitable for individuals with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, heart failure, serious infections, or alcoholism. Regular monitoring of blood sugar levels is essential. Inform your doctor if you have any history of kidney disease, liver disease, heart problems, severe infections, trauma, or are scheduled for surgery or vaccination. Long-term therapy may reduce vitamin B12 absorption, so annual screening of B12 levels is recommended.

What happens if a dose of ADVOG M 0.2 PLUS is missed?

If you miss a dose of ADVOG M 0.2 PLUS, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should ADVOG M 0.2 PLUS be stored?

ADVOG M 0.2 PLUS should be stored in a cool and dry place, away from direct sunlight. It should be kept out of sight and reach of children. The recommended storage temperature is typically below 30°C (10°C to 25°C).