Sitazit M Er 500mg Tab

SITAZIT M ER 500MG Tablet

SITAZIT M ER 500MG Tablet is a prescription medication manufactured by Glenmark Pharmaceuticals Ltd. (GLENMARK-HEALTHEON CARE DIV) designed for the management of Type 2 Diabetes Mellitus.

• Name:

  • Common Name: SITAZIT M ER 500MG Tablet
  • Brand Name: SITAZIT M ER 500MG

• Composition:

  • Active Ingredients: Sitagliptin (100 mg) and Metformin (500 mg).
    • Metformin, a biguanide, works by reducing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin.
    • Sitagliptin, a DPP-4 inhibitor, increases the levels of incretin hormones, which stimulate insulin release from the pancreas and decrease glucagon levels, particularly after meals.

• Uses: SITAZIT M ER 500MG Tablet is primarily used for:

  • Controlling high blood sugar levels in adults with Type 2 Diabetes Mellitus, in conjunction with a healthy diet and regular exercise.
  • Improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
  • Preventing serious complications associated with diabetes, such as kidney damage, blindness (retinopathy), nerve damage (neuropathy), diabetic foot ulcer, and reduced risk of heart attack or stroke.

• Dosage and Administration:

  • Take SITAZIT M ER 500MG Tablet with food as prescribed by your doctor.
  • It is typically taken twice daily, but the dosage may be adjusted by your doctor based on your blood sugar levels and condition.
  • Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
  • For best results, take it at the same time each day.

• Side Effects: Common side effects may include:

  • Low blood sugar (hypoglycemia), especially when taken with other anti-diabetic medicines (characterized by dizziness, sweating, hunger pangs, dry mouth, headache, palpitations).
  • Gastrointestinal issues: nausea, vomiting, diarrhea, stomach pain, abdominal bloating, changes in taste.
  • Upper respiratory tract infection, nasopharyngitis (common cold), headache, sore throat.
  • Rare but serious side effects include lactic acidosis (symptoms: vomiting, stomach pain, breathing difficulty, tiredness, muscle cramps, decreased body temperature, decreased heartbeat).

• Precautions:

  • Inform your doctor about any existing health conditions, such as severe kidney or liver disease, heart problems, pancreatitis, or low vitamin B12 levels.
  • Avoid alcohol consumption as it can increase the risk of lactic acidosis.
  • Not recommended for people with severe, uncontrolled diabetes, Type 1 Diabetes Mellitus, diabetic ketoacidosis, or if undergoing certain medical procedures requiring injected dye.
  • Pregnant or breastfeeding women should consult their doctor before using this medicine.
  • Regular monitoring of blood sugar levels and kidney function is crucial.
  • May cause dizziness or sleepiness; avoid driving or operating machinery if affected.

• Storage:

  • Store at a temperature not above 30°C in a cool and dry place.
  • Keep it out of the reach of children and pets.
  • Store in its original container, tightly closed, and away from sunlight and moisture.

1. What is SITAZIT M ER 500MG TAB used for?

SITAZIT M ER 500MG TAB is a combination medication primarily used to treat Type 2 diabetes mellitus in adults. It helps to control high blood sugar levels as an adjunct to diet and exercise. Managing blood sugar is crucial to prevent serious complications of diabetes like kidney damage, blindness, nerve problems, and reduced risk of heart attack or stroke.

2. How does SITAZIT M ER 500MG TAB work?

This medicine contains two active ingredients: Sitagliptin and Metformin.

• Sitagliptin (100mg) works by increasing the levels of natural substances called incretins, which help control blood sugar by increasing insulin release from the pancreas, especially after meals, and decreasing the amount of sugar the liver makes.
• Metformin (500mg, extended-release) reduces the amount of glucose produced by your liver, slows down the absorption of sugars from the intestines, and enhances the body's sensitivity to insulin, helping your body use insulin more effectively.

3. What is the usual dosage of SITAZIT M ER 500MG TAB?

The dosage of SITAZIT M ER 500MG TAB should be individualized as directed by your doctor. It is typically taken once daily with food, preferably in the evening, to help reduce potential gastrointestinal side effects. Do not exceed the prescribed dose without consulting your doctor.

4. How should SITAZIT M ER 500MG TAB be taken?

Take SITAZIT M ER 500MG TAB by mouth with water. It should be taken with food, ideally at the start of a meal, to minimize stomach upset. It is important to swallow the tablets whole and not to crush, cut, or chew them.

5. What are the possible side effects of SITAZIT M ER 500MG TAB?

Common side effects may include diarrhea, nausea, vomiting, upset stomach, headache, and upper respiratory tract infections. Hypoglycemia (low blood sugar) can occur, especially if taken with other diabetes medications. More serious, but rare, side effects include lactic acidosis (a build-up of acid in the blood), pancreatitis (inflammation of the pancreas), heart failure, kidney injury, and low vitamin B12 levels.

6. Is SITAZIT M ER 500MG TAB safe during pregnancy or breastfeeding?

SITAZIT M ER 500MG TAB is generally not recommended during pregnancy, as there is limited information on its effects on a developing baby, and metformin components could cause harm to the unborn baby. For breastfeeding mothers, the sitagliptin component is not usually recommended as it's unknown how much passes into breast milk. Metformin does pass into breast milk in tiny amounts but has not been linked to side effects in breastfed babies. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as they may recommend alternative treatments.

7. Can SITAZIT M ER 500MG TAB be taken with other medications?

SITAZIT M ER 500MG TAB can interact with several medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking. Particular caution is needed with:

• Other anti-diabetic medicines, including insulin or sulfonylureas, due to an increased risk of low blood sugar.
• Alcohol, as it can increase the risk of lactic acidosis.
• Certain contrast agents used for imaging scans (CT or X-rays).
• Cationic medicines like amiloride, digoxin, and morphine.
• Medicines affecting glycemic control such as corticosteroids, thiazides, and oral contraceptives.

8. What precautions should be taken while taking SITAZIT M ER 500MG TAB?

Before taking this medication, inform your doctor if you have kidney, liver, or heart disease, a history of pancreatitis, or if you frequently consume alcohol. Regular monitoring of kidney function and blood sugar levels is essential. You may need to temporarily stop taking this medication before surgery or imaging scans. Stay well-hydrated to prevent dehydration. Watch for symptoms of lactic acidosis (muscle pain, trouble breathing, stomach pain, unusual tiredness) or pancreatitis (severe stomach pain, nausea, vomiting) and seek immediate medical attention if they occur.

9. What should I do if I miss a dose of SITAZIT M ER 500MG TAB?

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

10. How should SITAZIT M ER 500MG TAB be stored?

Store SITAZIT M ER 500MG TAB at room temperature, typically between 20 and 25 degrees Celsius (68 and 77 degrees Fahrenheit). Keep it in a closed container, away from heat, moisture, and direct light. Ensure it is kept out of the reach of children.