Arnicor 200

ARNICOR 200

ARNICOR 200 is a prescription medicine manufactured by Cipla Ltd., primarily used in the management of chronic heart failure.

• Composition: Each ARNICOR 200 tablet contains Sacubitril 97 mg and Valsartan 103 mg. Sacubitril is a neprilysin inhibitor, and Valsartan is an angiotensin II receptor blocker (ARB). This combination works by relaxing and widening blood vessels, thus making it easier for the heart to pump blood throughout the body.

• Uses: ARNICOR 200 is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction. It also aids in the management of hypertension and offers cardiovascular protection by lowering blood pressure and reducing the risk of heart-related issues.

• Dosage and Administration: The medication is taken orally. Tablets should be swallowed whole with water and not crushed, chewed, or broken. It can be taken with or without food, preferably at a consistent time each day. The recommended starting dose of ARNICOR is generally 49/51 mg twice-daily, with the dose doubled to the target maintenance dose of 97/103 mg (ARNICOR 200) twice daily after 2 to 4 weeks, as tolerated. Do not stop the medication abruptly without consulting a doctor.

• Side Effects: Common side effects include dizziness, light-headedness (low blood pressure), cough, nausea, diarrhea, fatigue, headache, and elevated potassium levels (hyperkalemia). More serious side effects, such as allergic reactions or chest pain, warrant immediate medical attention.

• Precautions: ARNICOR 200 is contraindicated in patients with an allergy to sacubitril or valsartan, severe liver disease, or during pregnancy and breastfeeding. It should not be taken with ACE inhibitors; a 36-hour washout period is required between these medications. Caution is advised for patients with kidney or moderate liver impairment. Avoid alcohol and potassium-rich foods or supplements unless directed by a healthcare professional. This medication may cause dizziness, so caution is needed when driving or operating machinery.

• Storage: Store ARNICOR 200 tablets in a cool, dry place, protected from direct sunlight, heat, and moisture, ideally below 30°C. Keep out of reach of children and pets.

Here are the most frequently asked questions about ARNICOR 200 by CIPLA HEALTH LIMITED:

What is ARNICOR 200 used for?

ARNICOR 200 is used to treat chronic heart failure in adults, specifically in patients with New York Heart Association (NYHA) Class II-IV heart failure and reduced ejection fraction. Its primary purpose is to reduce the risk of cardiovascular death and hospitalizations related to heart failure.

How does ARNICOR 200 work?

ARNICOR 200 is a combination medicine containing sacubitril and valsartan. Sacubitril is a neprilysin inhibitor, which works by increasing the levels of certain beneficial peptides in the body that relax blood vessels and reduce fluid retention. Valsartan is an angiotensin receptor blocker (ARB) that blocks the effects of a hormone that narrows blood vessels. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood throughout the body and reducing its workload.

What is the usual dosage of ARNICOR 200?

The recommended starting dose for ARNICOR (which may be a different strength than ARNICOR 200) is often 49/51 mg taken orally twice daily. The dose is typically doubled after 2 to 4 weeks to a target maintenance dose of 97/103 mg twice daily, as tolerated by the patient. ARNICOR 200 mg tablets usually contain 97 mg of sacubitril and 103 mg of valsartan. Always follow your doctor's specific instructions for dosage and duration. It can be taken with or without food, preferably at a fixed time each day.

What are the possible side effects of ARNICOR 200?

Common side effects include dizziness, low blood pressure (hypotension), elevated potassium levels in the blood (hyperkalemia), cough, and impaired kidney function. Other possible side effects may include nausea, diarrhea, tiredness, headache, weakness, and fainting. If any side effects worsen or persist, consult your doctor immediately.

Is ARNICOR 200 safe during pregnancy or breastfeeding?

No, ARNICOR 200 is not recommended and is considered unsafe during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. It is also not recommended for use by breastfeeding mothers. Inform your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.

Can ARNICOR 200 be taken with other medications?

ARNICOR 200 has significant drug interactions. It should not be taken with ACE inhibitors; a washout period of at least 36 hours is required between stopping an ACE inhibitor and starting ARNICOR 200. It should also be avoided with other angiotensin receptor blockers (ARBs) and aliskiren (especially in patients with diabetes or kidney disease). Caution is advised when taking it with potassium supplements, potassium-containing salt substitutes, NSAIDs (painkillers), lithium, and sildenafil. Always inform your doctor about all other medications, herbal preparations, and supplements you are currently taking.

What precautions should be taken with ARNICOR 200?

Regular monitoring of blood pressure, kidney function, and potassium levels is important while taking ARNICOR 200. To prevent dizziness from low blood pressure, rise slowly from a sitting or lying position. Avoid alcohol consumption, as it can increase dizziness. Inform your doctor if you have kidney or liver disease, dehydration, vomiting, diarrhea, or a history of angioedema (swelling of the face, lips, tongue, or throat).

What happens if a dose of ARNICOR 200 is missed?

If you miss a dose of ARNICOR 200, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ARNICOR 200 be stored?

ARNICOR 200 tablets should be stored in a cool, dry place, typically below 30°C (or between 10ºC and 25ºC), away from direct sunlight, heat, and moisture. Keep the medication out of the sight and reach of children and pets. Do not use the medicine after its expiry date.