Pregabid D 75/20

PREGABID D 75/20 by INTAS PHARMACEUTICALS LTD

Name

• Brand Name: PREGABID D 75/20 Capsule (or Capsule DR)

Composition

PREGABID D 75/20 is a combination medicine containing two active ingredients:

• Pregabalin: 75 mg. This belongs to an anticonvulsant class of drugs.
• Duloxetine: 20 mg. This is a selective serotonin and norepinephrine reuptake inhibitor (SNRI).

Uses

PREGABID D 75/20 is primarily prescribed for the management of pain and other associated symptoms.

• Neuropathic Pain: Including diabetic neuropathic pain (nerve damage due to diabetes), postherpetic neuralgia (pain after shingles), spinal cord injury, and other nerve-related pain conditions. It works by interfering with pain signals and improving nerve conduction.
• Fibromyalgia: A chronic condition characterized by widespread musculoskeletal pain and tenderness.
• Associated Symptoms: It can also help improve sleep disturbances and mood changes often linked with chronic pain conditions. Duloxetine, one of its components, is also used to treat depression and anxiety disorders.

Dosage and Administration

• PREGABID D 75/20 should be taken orally, exactly as prescribed by your doctor.
• It can be taken with or without food.
• Swallow the capsule whole with a glass of water; do not chew, crush, or break it.
• For optimal results and to maintain a consistent level of medication, it is advisable to take it at the same time each day.
• Do not exceed the recommended dose, as this may increase the risk of side effects or overdose.
• Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms such as dizziness, tingling sensation, sleep disturbances, restlessness, nausea, vomiting, headache, or excessive sweating. Your doctor will likely reduce the dosage gradually.

Side Effects

Common side effects may include:

• Dizziness, drowsiness, tiredness, headache
• Nausea, constipation, dry mouth, loss of appetite
• Increased sweating, burning sensation
• Blurred vision, difficulty in concentrating
• Weight gain, swelling of hands and feet, uncoordinated body movements
• Insomnia (difficulty in sleeping), ejaculation disorder, erectile dysfunction

Serious side effects, though less common, or symptoms of overdose may include:

• Mood changes, memory problems, confusion, anxiety, reduced sexual drive
• Increased suicidal thoughts, particularly in children and young adults.
• Autonomic instability, coma, excessive sleepiness, muscle twitching, numbness, seizures, somnolence, speech disturbances, syncope, tachycardia, and vomiting (in case of overdose).

If any side effects persist or worsen, consult your healthcare provider.

Precautions

• Allergies: Avoid if allergic to Pregabalin, Duloxetine, or any other components of the medicine.
• Medical Conditions: Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, heart conditions, diabetes, fluctuating blood pressure, or are at risk of hyponatremia (low sodium levels).
• Pregnancy and Breastfeeding: Consult your doctor before using PREGABID D 75/20 if you are pregnant, planning a pregnancy, or breastfeeding.
• Children and Elderly: Not recommended for use in children below 18 years of age due to increased risk of suicidal tendencies. Use with caution in elderly patients (over 65 years), as dose adjustments may be required due to a higher risk of side effects.
• Alcohol Interaction: Avoid or limit alcohol consumption while taking this medicine, as it can increase side effects such as drowsiness, dizziness, blurred vision, and may increase the risk of liver damage.
• Driving and Machinery: PREGABID D 75/20 may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how the medicine affects you.
• Drug Interactions: Inform your doctor about all other medicines, supplements, or herbal products you are currently taking to avoid potential drug interactions. Specific interactions include those with medicines for brain-related disorders, oxycodone, blood thinners, and it is contraindicated with monoamine oxidase inhibitors.
• Food Interactions: Avoid consuming grapefruit or grapefruit juice as it may increase the levels of the medication in your bloodstream.
• Dependence: Pregabalin has a potential for abuse and dependence; take only as prescribed.
• Monitoring: Regular monitoring by your doctor is recommended, especially for blood pressure during the first month of treatment. Report any unusual changes in mood or behavior immediately.

Storage

• Store PREGABID D 75/20 in a cool and dry place.
• Protect from direct sunlight, moisture, and heat.
• Maintain storage at room temperature, typically between 10°C to 25°C or below 30°C.
• Keep out of the sight and reach of children and pets.

Here are frequently asked questions about PREGABID D 75/20 by INTAS PHARMACEUTICALS LTD, along with concise answers:

What is PREGABID D 75/20 used for?

PREGABID D 75/20 is a combination medicine primarily used to treat neuropathic pain, which is pain caused by nerve damage due to conditions like diabetes, shingles (herpes zoster infection), or spinal cord injury. It is also prescribed for the management of fibromyalgia and can help with associated anxiety disorders.

How does PREGABID D 75/20 work?

This medicine contains two active ingredients: Pregabalin and Duloxetine. Pregabalin is an anticonvulsant that works by modulating calcium channels on nerve cells, which reduces the release of neurotransmitters that send pain signals. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) that increases the levels of serotonin and norepinephrine in the brain. These chemical messengers help regulate mood and pain. Together, they work synergistically to relieve nerve pain and can also improve sleep and mood disturbances often associated with chronic pain.

What is the usual dosage for PREGABID D 75/20?

The dosage and duration of PREGABID D 75/20 are determined by your doctor based on your medical condition and response to treatment. The capsules should be swallowed whole with water, and should not be crushed, chewed, or broken. It can be taken with or without food. To achieve the best results and maintain a consistent level of the medicine in your body, it is advisable to take it at the same time each day. Never exceed the prescribed dose.

What are the possible side effects of PREGABID D 75/20?

Common side effects may include dizziness, sleepiness, tiredness, nausea, dry mouth, constipation, headache, weight gain, swelling in your hands or feet, blurred vision, and difficulty concentrating. Less common or more serious side effects can include mood changes, increased risk of suicidal thoughts (especially in young adults), abnormal bleeding, and low sodium levels. If any side effects persist or worsen, or if you experience any severe reactions, consult your doctor immediately.

Is PREGABID D 75/20 safe during pregnancy or breastfeeding?

PREGABID D 75/20 is generally not recommended during pregnancy or breastfeeding unless specifically prescribed by a doctor who has carefully weighed the potential benefits against the risks. There is limited safety information regarding its use during pregnancy, and animal studies have shown harmful effects on developing babies. The medicine can also pass into breastmilk and may harm the infant.

Can PREGABID D 75/20 be taken with other medications?

PREGABID D 75/20 can interact with several other medications. It should not be taken with monoamine oxidase inhibitors (MAOIs), a class of antidepressants, as this can increase the risk of severe side effects. Concurrent use with other central nervous system depressants, such as opioids or benzodiazepines, can enhance sedative effects, leading to increased drowsiness and dizziness. Taking it with blood thinners like aspirin, warfarin, or nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of abnormal bleeding. Always inform your doctor about all other medications, supplements, and herbal products you are currently taking to avoid potential drug interactions.

What precautions should be taken while taking PREGABID D 75/20?

Avoid consuming alcohol while taking PREGABID D 75/20, as it can increase side effects like dizziness, drowsiness, and impaired thinking. Due to potential drowsiness and dizziness, it is advised not to drive or operate heavy machinery until you know how the medicine affects you. Do not stop taking PREGABID D 75/20 abruptly, as this can lead to withdrawal symptoms such as headache, mood swings, irritability, or dizziness. Use with caution if you have kidney or liver problems, glaucoma, heart disease, or diabetes. Your doctor may need to adjust the dose or monitor your condition closely. Regular monitoring for mood changes or suicidal thoughts is also recommended. It is also advisable to avoid grapefruit and grapefruit juice.

What happens if a dose of PREGABID D 75/20 is missed?

If you miss a dose of PREGABID D 75/20, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should PREGABID D 75/20 be stored?

Store PREGABID D 75/20 at room temperature, typically between 20-25°C or below 30°C. Keep it in a dry place, away from moisture, heat, and direct sunlight. Ensure it is kept out of the sight and reach of children and pets.