Sacuhart 50 Tab

SACUHART 50 TABLET

SACUHART 50 TABLET, manufactured by Macleods Pharmaceuticals Ltd, is a prescription medicine used in the management of chronic heart failure.

• Name

  • Brand Name: SACUHART 50 TABLET
  • Common Name: Sacubitril and Valsartan

• Composition Each SACUHART 50 TABLET contains a combination of two active ingredients:

  • Sacubitril: 24 mg
  • Valsartan: 26 mg This combination belongs to a class of medicines known as Angiotensin Receptor Neprilysin Inhibitors (ARNI).

• Uses SACUHART 50 TABLET is primarily prescribed for:

  • Reducing the risk of cardiovascular death and hospitalization in adults with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.
  • Treatment of heart failure in adults and children above one year of age. It works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body and helping to reduce fluid retention.

• Dosage and Administration SACUHART 50 TABLET should be taken exactly as advised by your doctor.

  • Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
  • It can be taken with or without food, preferably at the same time each day to maintain consistency.
  • Do not exceed the recommended dose or stop taking the medicine without consulting your doctor, even if you feel better.

• Side Effects Common side effects may include:

  • Dizziness, light-headedness (low blood pressure)
  • Cough
  • Headache, tiredness, weakness, nausea
  • Signs of high levels of potassium in the blood (hyperkalemia), such as irregular heartbeat or muscle weakness
  • Decrease in renal function (impaired kidney function)
  • Diarrhea Serious but rare side effects include angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention.

• Precautions

  • Pregnancy: Contraindicated in early pregnancy and must not be used after the first 3 months of pregnancy due to serious harm to the baby.
  • Breastfeeding: Not recommended for use in breastfeeding women.
  • Allergy: Avoid if allergic to sacubitril, valsartan, or any other components.
  • Drug Interactions:
    • Do not take with ACE inhibitors (e.g., captopril, enalapril); wait at least 36 hours before or after taking an ACE inhibitor.
    • Avoid concomitant use with aliskiren, especially in patients with diabetes or kidney disease.
    • Caution with NSAIDs (painkillers), potassium supplements, potassium-containing salt substitutes, or heparin, as these may increase blood potassium levels or worsen kidney function.
    • Concomitant use with sildenafil can cause a further decrease in blood pressure.
  • Medical Conditions:
    • Use with caution in patients with liver disease (contraindicated in severe liver disease) and kidney disease.
    • Inform your doctor if you have a history of angioedema or diabetes.
  • Driving and Alcohol: May cause dizziness or tiredness; avoid driving or operating heavy machinery if affected. Alcohol consumption should be limited or avoided as it may worsen dizziness.
  • Diet: Limit salt intake and avoid potassium-rich foods unless advised by a doctor.

• Storage Store in a cool and dry place, away from direct sunlight and moisture. Keep out of the sight and reach of children. Typically stored below 25°C or 30°C.

SACUHART 50 TAB is a medication typically prescribed for chronic heart failure. It is a combination of two active ingredients, Sacubitril and Valsartan, which work together to improve heart function and reduce the risk of complications.

What is SACUHART 50 TAB used for?

SACUHART 50 TAB is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of hospitalization and death associated with this condition. The medication can also alleviate symptoms of heart failure such as breathlessness, fatigue, and ankle swelling. In some cases, it may be used in children aged one year and older with symptomatic heart failure.

How does SACUHART 50 TAB work?

SACUHART 50 TAB is a combination of Sacubitril and Valsartan. Sacubitril is a neprilysin inhibitor that works by relaxing and widening blood vessels, increasing the excretion of sodium and urine, and reducing fluid retention, thereby easing the heart's pumping action. Valsartan is an Angiotensin Receptor Blocker (ARB) that blocks the action of angiotensin II, a substance that causes blood vessels to constrict. By doing so, Valsartan relaxes blood vessels, lowers blood pressure, and reduces the workload on the heart. Together, these components help improve heart function and blood flow.

What is the usual dosage for SACUHART 50 TAB?

The dosage and frequency of SACUHART 50 TAB are determined by your doctor based on your medical condition and response to treatment. It can be taken with or without food, but it is recommended to take it at the same time each day for maximum benefit. The tablet should be swallowed whole with water and should not be chewed, crushed, or broken. Do not exceed the recommended dose.

What are the possible side effects of SACUHART 50 TAB?

Common side effects include dizziness, light-headedness (due to low blood pressure), cough, nausea, diarrhea, weakness, tiredness, headache, high potassium levels (hyperkalemia), and decreased kidney function. In rare cases, more serious side effects like angioedema (swelling of the face, lips, tongue, or throat, which can be life-threatening) may occur and require immediate medical attention. If you experience any severe or persistent side effects, you should inform your doctor.

Is SACUHART 50 TAB safe during pregnancy or breastfeeding?

Pregnancy: SACUHART 50 TAB is considered unsafe and is not recommended during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. If you become pregnant while taking this medication, stop taking it and contact your doctor immediately.

Breastfeeding: It is not recommended to take SACUHART 50 TAB while breastfeeding. Limited human data suggests that the drug may pass into breast milk and could be harmful to the baby.

Can SACUHART 50 TAB be taken with other medications?

SACUHART 50 TAB can interact with several other medications:

• ACE inhibitors: Do not take SACUHART 50 TAB within 36 hours before or after taking an ACE inhibitor (e.g., enalapril, lisinopril) due to an increased risk of a severe allergic reaction called angioedema.
• Aliskiren: Concomitant use with aliskiren (a blood pressure-lowering medicine) is contraindicated, especially in patients with diabetes or impaired kidney function, as it increases the risk of low blood pressure, high potassium levels, and decreased kidney function.
• Potassium supplements, potassium-sparing diuretics, or potassium-containing salt substitutes: These can increase the risk of high potassium levels in the blood when taken with SACUHART 50 TAB.
• NSAIDs (painkillers): May reduce the effectiveness of SACUHART 50 TAB and potentially worsen kidney function, especially in elderly, dehydrated patients, or those with kidney disease.
• Lithium: May increase lithium levels in the blood.
• Other blood pressure-lowering medications: Taking other antihypertensive drugs may further reduce blood pressure.
• Sildenafil: Can lead to a further decrease in blood pressure.

Always inform your doctor about all other medications, supplements, and herbal products you are taking to avoid potential drug interactions.

What precautions should be taken with SACUHART 50 TAB?

• Do not stop taking SACUHART 50 TAB without consulting your doctor, even if your symptoms improve, as heart failure requires long-term management.
• Inform your doctor if you have kidney or liver problems, diabetes, or a history of hereditary angioedema.
• Regular monitoring of blood pressure, kidney function, and potassium levels will be necessary while on this medication.
• Avoid alcohol consumption as it can increase the blood pressure-lowering effect and worsen dizziness.
• Avoid driving or operating heavy machinery if you experience dizziness or fatigue.
• Limit salt intake and avoid potassium-rich foods (like bananas and broccoli) unless specifically advised by your doctor.
• To prevent dizziness, rise slowly when moving from a sitting or lying position.

What happens if a dose of SACUHART 50 TAB is missed?

If you miss a dose of SACUHART 50 TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should SACUHART 50 TAB be stored?

SACUHART 50 TAB should be stored in a cool and dry place, away from direct sunlight. It is typically stored at room temperature, ideally between 10°C to 25°C or below 30°C. Keep the medication out of the sight and reach of children. Protect it from moisture and light.