Preva As 75 Mg Tablet (15 Tab)

PREVA AS 75 MG TABLET (15 TAB)

PREVA AS 75 MG TABLET, manufactured by INTAS PHARMACEUTICALS LTD., is an antiplatelet medication designed to prevent the formation of harmful blood clots.

• Composition Each tablet contains Aspirin (Acetylsalicylic Acid) 75 mg and Clopidogrel 75 mg.

• Uses PREVA AS 75 MG TABLET is prescribed to reduce the risk of cardiovascular events such as heart attacks and strokes. It is used in patients with acute coronary syndrome, those who have experienced a recent heart attack or stroke, and for post-heart attack care or after procedures like coronary artery bypass graft (CABG) surgery or stent placement. The medicine also helps prevent deep vein thrombosis and pulmonary embolism.

• Dosage and Administration The typical dosage is one tablet daily, taken orally with food at the same time each day. It should be swallowed whole with a glass of water; do not crush, chew, or break the tablet. The dosage and duration of treatment should be strictly followed as prescribed by a doctor.

• Side Effects Common side effects include nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhea, stomach pain, indigestion, and heartburn. More serious side effects, such as excessive or prolonged bleeding, black tarry stools, blood in urine, signs of stroke, liver damage, or allergic reactions, should be reported to a doctor immediately.

• Precautions This medicine increases the risk of bleeding, so caution is advised during activities like shaving or using sharp objects. Alcohol consumption should be avoided as it can increase the chances of stomach bleeding. Inform your doctor if you have allergies to aspirin, liver or kidney disease, bleeding disorders, stomach ulcers, or respiratory problems. It is generally not recommended during pregnancy or breastfeeding without consulting a doctor. Avoid taking other NSAIDs concurrently without medical advice. Do not stop taking the medicine abruptly.

• Storage Store PREVA AS 75 MG TABLET in a cool and dry place, protected from direct sunlight and moisture. Keep it out of sight and reach of children and pets, typically below 30°C.

What is PREVA AS 75 MG TABLET used for?

PREVA AS 75 MG TABLET is a combination medication used to prevent blood clots. It is primarily prescribed to reduce the risk of serious cardiovascular events such as heart attacks and strokes in individuals who have a history of these conditions, or those at high risk due to conditions like unstable angina or peripheral artery disease. It is also used after certain heart procedures, such as coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) with stent placement, to prevent clots from forming within the graft or stent. This medication is for preventive treatment and is not recommended for emergency use, such as during an ongoing heart attack.

How does PREVA AS 75 MG TABLET work?

PREVA AS 75 MG TABLET contains two antiplatelet agents: Aspirin and Clopidogrel. Aspirin works by irreversibly inhibiting the cyclooxygenase (COX) enzyme, which reduces the production of thromboxane A2, a substance that causes platelets to clump together and form blood clots. Clopidogrel works through a different mechanism by blocking the binding of adenosine diphosphate (ADP) to its specific platelet receptor, which also inhibits platelet aggregation. By combining these two mechanisms, PREVA AS 75 MG TABLET effectively prevents blood clots from forming and helps maintain smooth blood flow in the arteries.

What is the usual dosage for PREVA AS 75 MG TABLET?

The typical dosage for PREVA AS 75 MG TABLET is one tablet (75mg Aspirin and 75mg Clopidogrel) taken once daily. It is important to follow your doctor's instructions precisely and take the medication at the same time each day to maintain a consistent level of medicine in your body. The tablets should be swallowed whole with water and should not be crushed, broken, or chewed, especially if they are enteric-coated, as this coating helps protect your stomach. It can be taken with or without food, though taking it with food may help reduce stomach discomfort.

What are the possible side effects of PREVA AS 75 MG TABLET?

Common side effects of PREVA AS 75 MG TABLET include an increased risk of bleeding (such as easy bruising, nosebleeds, or gastrointestinal bleeding), stomach upset (like nausea, vomiting, abdominal pain, indigestion, and heartburn), and diarrhea.

Less common but serious side effects can include severe allergic reactions (e.g., skin rash, swelling of the face, lips, throat, or tongue, and difficulty breathing), liver damage, or a type of stroke caused by bleeding (hemorrhagic stroke). If you experience severe or persistent side effects, such as black or tarry stools, vomiting blood, severe stomach pain, or unusual bleeding or bruising, seek immediate medical attention.

Is PREVA AS 75 MG TABLET safe during pregnancy or breastfeeding?

Pregnancy: Low-dose aspirin may be prescribed by your doctor or midwife during pregnancy, particularly if you are at high risk of conditions like pre-eclampsia. However, high-dose aspirin is generally not recommended, especially during the last trimester, as it can cause serious complications for the baby's circulation, kidneys, and potentially affect labor and delivery. Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, should generally be avoided from 20 weeks gestation onwards due to the risk of fetal kidney problems. Always consult your doctor before taking this medicine if you are pregnant or planning a pregnancy.

Breastfeeding: Low-dose aspirin (75-150mg daily) is generally considered compatible with breastfeeding by many experts, as only small amounts pass into breast milk. However, high or regular analgesic doses of aspirin are typically not recommended for breastfeeding mothers due to a possible link with Reye's syndrome in infants, especially if the infant has a viral infection. Paracetamol or ibuprofen are usually preferred for pain relief during breastfeeding. Always consult your doctor before using PREVA AS 75 MG TABLET while breastfeeding.

Can PREVA AS 75 MG TABLET be taken with other medications?

PREVA AS 75 MG TABLET can interact with several other medications, increasing the risk of side effects, particularly bleeding. It is crucial to inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins.

Key interactions include:

• Other NSAIDs (e.g., ibuprofen, naproxen): Concomitant use can significantly increase the risk of stomach bleeding and ulcers.
• Anticoagulants (blood thinners like warfarin, heparin, apixaban, rivaroxaban): Taking these with PREVA AS 75 MG TABLET dramatically increases the risk of bleeding.
• SSRIs (certain antidepressants like citalopram, fluoxetine, sertraline): These can also increase the risk of bleeding when taken with aspirin.
• Certain medications for high blood pressure (e.g., ACE inhibitors, diuretics) or epilepsy (e.g., phenytoin): Interactions may occur.
• Herbal supplements: Some, like feverfew, garlic, ginger, and ginkgo biloba, can increase bleeding risk.
• Alcohol: Drinking alcohol regularly while taking this medication can also increase the risk of stomach bleeding.

Always discuss potential drug interactions with your doctor or pharmacist.

What precautions should be taken while taking PREVA AS 75 MG TABLET?

Several precautions should be observed when taking PREVA AS 75 MG TABLET:

• Allergies: Do not take this medicine if you are allergic to aspirin, clopidogrel, other salicylates, or other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen.
• Bleeding Disorders/Ulcers: This medication is not recommended if you have active bleeding, a history of bleeding disorders (like haemophilia), or current/recurrent stomach or intestinal ulcers or bleeding.
• Children and Adolescents: Aspirin should not be given to children or adolescents under 16 years of age without medical supervision, especially if they have a fever, flu symptoms, or chickenpox, due to the rare but life-threatening risk of Reye's syndrome.
• Underlying Medical Conditions: Exercise caution and inform your doctor if you have severe liver or kidney problems, asthma (aspirin can worsen symptoms), or uncontrolled high blood pressure.
• Surgery/Dental Procedures: Inform your doctor or dentist that you are taking this medication before any surgery or dental treatment, as it can increase bleeding time.
• Dehydration: Avoid dehydration while taking this medicine, as it may worsen kidney function.
• Not for Pain/Fever: This low-dose medication is for preventing blood clots and is not suitable for relieving pain or reducing fever.

What happens if a dose of PREVA AS 75 MG TABLET is missed?

If you miss a dose of PREVA AS 75 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

How should PREVA AS 75 MG TABLET be stored?

PREVA AS 75 MG TABLET should be stored in a cool, dry place, typically below 25°C. Keep the tablets in their original packaging to protect them from moisture and light. Always ensure the medicine is kept out of the sight and reach of children. Do not use the medicine after the expiry date printed on the carton.