Eurepa Mf 1 Mg Tablet (10 Tab)

EUREPA MF 1 MG TABLET

EUREPA MF 1 MG TABLET is an oral anti-diabetic medication manufactured by Torrent Pharmaceuticals Ltd. It is a combination therapy designed to manage type 2 diabetes mellitus in adults.

Composition

• Repaglinide: 1 mg
• Metformin Hydrochloride: 500 mg

Uses

EUREPA MF 1 MG TABLET is primarily used for the management of type 2 diabetes mellitus in adults. It is typically prescribed when diet and exercise alone, or monotherapy with either repaglinide or metformin, are insufficient to achieve adequate blood sugar control. This medication helps to control blood glucose levels and reduces the risk of long-term diabetes-related complications affecting the eyes, kidneys, nerves, and heart.

Repaglinide, a meglitinide, stimulates the pancreas to release more insulin, especially after meals, helping to control post-meal blood sugar spikes. Metformin, a biguanide, reduces glucose production in the liver, decreases sugar absorption from the gut, and enhances the body's sensitivity to insulin, improving glucose uptake and utilization by body tissues.

Dosage and Administration

The dosage of EUREPA MF 1 MG TABLET should be individualized based on the patient's current regimen, effectiveness, and tolerability, as determined by a healthcare provider.

• Administration: The tablets are taken orally. They should be swallowed whole with a glass of water, usually 15-30 minutes before a meal. Do not crush, chew, or break the tablet.
• Frequency: It can be administered 2 to 3 times a day.
• Missed Dose: If a meal is skipped, the dose meant for that meal should also be skipped.
• Maximum Dose: No more than 4 mg Repaglinide/1000 mg Metformin Hydrochloride should be taken per meal, with a maximum daily dose of 10 mg Repaglinide/2500 mg Metformin Hydrochloride.

Side Effects

Common side effects include:

• Hypoglycemia (low blood sugar), with symptoms like shakiness, sweating, confusion, dizziness, and blurry vision.
• Diarrhea.
• Nausea and vomiting.
• Abdominal pain/discomfort.
• Headache.
• Joint pain (arthralgia).
• Respiratory tract infections (cough, sore throat, runny nose).
• Taste disturbance.

Serious side effects, though rare, can include:

• Lactic acidosis, especially in patients with kidney, heart, or liver conditions. Symptoms may include fatigue, breathing difficulty, increased sleepiness, irregular heartbeat, and severe stomach upset.
• Severe allergic reactions.
• Abnormal liver tests.

Precautions

• Hypoglycemia: Patients should be aware of hypoglycemia symptoms and carry a fast-acting source of glucose.
• Alcohol: Avoid excessive alcohol intake as it increases the risk of lactic acidosis and hypoglycemia.
• Pregnancy: Caution is advised; consult a doctor. It may be unsafe during pregnancy.
• Breastfeeding: Caution is recommended; likely unsafe during breastfeeding.
• Kidney Impairment: Use with caution and dose adjustment may be required. Not recommended in severe renal disease due to increased risk of lactic acidosis.
• Liver Impairment: Use with caution and dose adjustment may be required. Not recommended in severe hepatic impairment.
• Drug Interactions: Inform your doctor about all other medications, especially lipid-regulating medicines (e.g., gemfibrozil), anti-epileptic medications (e.g., carbamazepine), calcium channel blockers (e.g., nifedipine), thiazide diuretics, ACE inhibitors, corticosteroids, anabolic steroids, and oral contraceptives, as they can interact with EUREPA MF 1 MG TABLET.
• Other Conditions: Not recommended for type 1 diabetes, diabetic ketoacidosis, metabolic acidosis, or severe cardiac/respiratory failure. Caution is advised in patients with congestive heart failure.
• Driving: Ability to drive may be affected by very low or very high blood sugar levels. Use caution.

Storage

Store at room temperature (10-30°C).EUREPA MF 1 MG TABLET is an oral anti-diabetic medication manufactured by Torrent Pharmaceuticals Ltd., used for the management of type 2 diabetes mellitus in adults.

Name

• Brand Name: EUREPA MF 1 MG TABLET
• Common Name: Repaglinide and Metformin Hydrochloride Tablets

Composition

• Active Ingredients: Each film-coated tablet contains Repaglinide 1 mg and Metformin Hydrochloride 500 mg.

Uses

EUREPA MF 1 MG TABLET is prescribed to improve glycemic control in adults with type 2 diabetes mellitus. It is particularly indicated when diet and exercise alone, or monotherapy with either repaglinide or metformin, are insufficient to adequately control blood sugar levels. This combination medication helps prevent high blood sugar, which can lead to serious complications such as kidney damage, blindness, nerve problems, and loss of limbs.

Repaglinide, a meglitinide, stimulates the pancreas to release more insulin, especially after meals, thereby managing post-meal blood sugar spikes. Metformin, a biguanide, works by decreasing glucose production in the liver, reducing sugar absorption from the gut, and enhancing the body's sensitivity to insulin, allowing cells to utilize glucose more effectively.

Dosage and Administration

The dosage of EUREPA MF 1 MG TABLET is individualized based on the patient's current regimen, effectiveness, and tolerability.

• Route: Oral.
• Timing: Tablets should generally be taken 15-30 minutes before meals. If a meal is skipped, the dose meant for that meal should also be skipped.
• Method: Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
• Frequency: Can be administered 2 to 3 times a day.
• Maximum Dose: The maximum daily dose is 10 mg Repaglinide/2500 mg Metformin Hydrochloride, with no more than 4 mg Repaglinide/1000 mg Metformin Hydrochloride per meal.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood sugar), characterized by shakiness, sweating, confusion, dizziness, and blurred vision.
• Diarrhea.
• Nausea, vomiting, and abdominal pain.
• Headache.
• Joint pain.
• Respiratory tract infections (e.g., cough, sore throat).
• Taste disturbance.

Serious Side Effects (rare but require immediate medical attention):

• Lactic acidosis, particularly in patients with kidney, heart, or liver issues.
• Severe allergic reactions.
• Abnormal liver function tests.

Precautions

• Hypoglycemia: Patients should be educated on recognizing and managing symptoms of low blood sugar, and always carry a fast-acting source of glucose.
• Alcohol: Avoid consuming alcohol, as it can increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy and Breastfeeding: EUREPA MF 1 MG TABLET is generally not recommended during pregnancy and breastfeeding. Consult a doctor for guidance.
• Kidney and Liver Impairment: Use with caution. Not recommended in severe kidney or liver disease due to increased risk of lactic acidosis and potential impact on drug metabolism.
• Drug Interactions: Inform your doctor about all other medications, including lipid-regulating medicines (e.g., gemfibrozil), anti-epileptic medications (e.g., carbamazepine), calcium channel blockers (e.g., nifedipine), corticosteroids, and certain blood pressure medications, as interactions can occur.
• Contraindications: Not recommended for type 1 diabetes mellitus, diabetic ketoacidosis, metabolic acidosis, or patients with severe cardiac or respiratory failure.
• Driving: Blood sugar fluctuations can affect the ability to drive or operate machinery. Exercise caution.

Storage

Store EUREPA MF 1 MG TABLET at room temperature, typically below 30°C.

What is EUREPA MF 1 MG TABLET used for?

EUREPA MF 1 MG TABLET is a combination medicine primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone are insufficient to control blood sugar levels, or when monotherapy with either repaglinide or metformin is not providing adequate glycemic control.

How does EUREPA MF 1 MG TABLET work?

This medicine contains two active ingredients: Repaglinide and Metformin. Repaglinide works by stimulating the pancreas to release more insulin, particularly after meals, which helps to control post-meal blood sugar spikes. Metformin, a biguanide, primarily functions by decreasing glucose production in the liver, reducing the absorption of glucose from the intestines, and improving the body's sensitivity to insulin, allowing cells to utilize glucose more effectively.

What is the usual dosage of EUREPA MF 1 MG TABLET?

The dosage of EUREPA MF 1 MG TABLET is individualized by your doctor based on your current blood sugar levels and response to the medication. It is typically taken 2 to 3 times a day with meals, usually within 15 minutes before a meal, but can be taken up to 30 minutes prior. The maximum daily dose should not exceed 10 mg of repaglinide and 2500 mg of metformin, with no more than 4 mg repaglinide and 1000 mg metformin per meal.

What are the possible side effects of EUREPA MF 1 MG TABLET?

Common side effects can include low blood sugar (hypoglycemia), diarrhea, nausea, vomiting, abdominal pain, headache, and taste disturbances. A serious but rare side effect is lactic acidosis, particularly in patients with kidney disease, heart disease, or septicemia. If you experience any severe or unusual symptoms, consult your doctor immediately.

Is EUREPA MF 1 MG TABLET safe during pregnancy or breastfeeding?

EUREPA MF 1 MG TABLET is generally not recommended for use during pregnancy as its potential harm to an unborn baby is not fully known. For breastfeeding women, caution is advised, and it is considered probably unsafe to use this medicine. It is important to consult your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Can EUREPA MF 1 MG TABLET be taken with other medications?

EUREPA MF 1 MG TABLET can interact with certain medications. For instance, lipid-regulating medicines like gemfibrozil can increase the effect of repaglinide, potentially leading to a higher risk of low blood sugar, and concomitant use with gemfibrozil is contraindicated. Anti-epileptic medications (e.g., carbamazepine) may decrease its effectiveness, while calcium channel blockers (e.g., nifedipine) can enhance its glucose-lowering effects. It is crucial to inform your doctor about all medications, supplements, and herbal products you are taking. Avoid excessive alcohol intake while on this medication as it can increase the risk of lactic acidosis and hypoglycemia.

What precautions should be taken while using EUREPA MF 1 MG TABLET?

Take this medicine with caution if you have a history of kidney disease, liver disease, or congestive heart failure, as these conditions can increase the risk of side effects like lactic acidosis. Regular monitoring of blood glucose levels, kidney function, and liver function is recommended by your doctor. Be aware of the symptoms of hypoglycemia (e.g., sweating, shaking, dizziness) and carry a source of fast-acting glucose.

What happens if a dose of EUREPA MF 1 MG TABLET is missed?

If you miss a dose of EUREPA MF 1 MG TABLET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you skip a meal, you should also skip the dose meant to be taken before that meal.

How should EUREPA MF 1 MG TABLET be stored?

EUREPA MF 1 MG TABLET should be stored at room temperature, ideally not exceeding 30°C. Keep it protected from light and moisture, and always store it out of the reach of children.