Isaz D Cap

ISAZ D CAP

ISAZ D CAP is a medication manufactured by ISAKURA HEALTHCARE DIV..

• Name:

  • Brand Name: ISAZ D CAP (also referred to as Isaz D 30mg/40mg Capsule)

• Composition: ISAZ D CAP is a combination medicine containing two active ingredients:

  • Domperidone (30 mg)
  • Esomeprazole (40 mg)

• Uses: This medication is prescribed to treat various gastrointestinal conditions, including:

  • Gastroesophageal Reflux Disease (GERD)
  • Acidity and Heartburn
  • Gastric and Duodenal Ulcers
  • Zollinger-Ellison Syndrome
  • Erosive Esophagitis (inflammation of the food pipe)
  • Nausea and Vomiting Domperidone acts as a prokinetic, enhancing stomach and intestinal movement, while Esomeprazole is a proton pump inhibitor that reduces stomach acid production.

• Dosage and Administration: ISAZ D CAP should be taken on an empty stomach, preferably before the first meal of the day. It should be swallowed whole with a glass of water, without crushing, breaking, or chewing. Adhere strictly to the dose and duration advised by your doctor.

• Side Effects: Common side effects may include:

  • Diarrhea
  • Stomach pain
  • Flatulence (gas)
  • Dry mouth
  • Headache
  • Dizziness In rare cases, it may increase the risk of irregular heartbeat, especially in patients over 60.

• Precautions:

  • Do not use if hypersensitive to domperidone, esomeprazole, or any inactive ingredients.
  • Use with caution in patients with kidney or liver disease; dose adjustment may be necessary.
  • Consult a doctor if pregnant or breastfeeding.
  • May decrease alertness or affect vision; avoid driving or activities requiring focus if these symptoms occur.
  • Avoid alcohol, as it can increase drowsiness and stomach acid production.
  • Inform your doctor about all other medications you are taking to prevent potential drug interactions (e.g., with CYP3A4 inhibitors, pH-dependent medications, antiplatelet medicines).

• Storage: Store ISAZ D CAP in its original container at room temperature, ideally between 15°C and 30°C. Keep it protected from direct sunlight and moisture, and out of the reach of children.

ISAZ D CAP, manufactured by ISAKURA HEALTHCARE DIV., is a combination medication containing Domperidone and Esomeprazole. It is commonly prescribed to manage various gastrointestinal issues by reducing stomach acid and improving digestive tract movement.

Here are some frequently asked questions about ISAZ D CAP:

What is ISAZ D CAP used for?

ISAZ D CAP is primarily used to treat gastroesophageal reflux disease (GERD), commonly known as acid reflux, and indigestion. It helps alleviate symptoms such as heartburn, stomach pain, irritation, acid reflux, and regurgitation. Additionally, it is prescribed for stomach and duodenal ulcers, Zollinger-Ellison syndrome (a condition involving excessive stomach acid production), and erosive esophagitis (inflammation of the food pipe). The medication also aids in relieving nausea and vomiting.

How does ISAZ D CAP work?

ISAZ D CAP combines two active ingredients: Esomeprazole and Domperidone. Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach by blocking an enzyme responsible for acid secretion. Domperidone is a prokinetic agent that enhances the movement of the stomach and intestines, which helps food pass more easily through the digestive tract and controls vomiting.

What is the usual dosage and how should it be taken?

The dose and duration of ISAZ D CAP should be followed as advised by your doctor. It is typically taken once daily, before the first meal of the day, or on an empty stomach, preferably in the morning. The capsule should be swallowed whole with a glass of water and should not be chewed, crushed, or broken.

What are the possible side effects of ISAZ D CAP?

Common side effects include diarrhea, stomach pain, flatulence, dry mouth, headache, and dizziness. These side effects are usually temporary and tend to resolve over time. More serious, though less common, side effects can include an increased risk of irregular heartbeat (serious arrhythmias), particularly in patients over 60. Long-term use may lead to a deficiency of minerals like magnesium and vitamin B12, and might increase the risk of bone fractures. There's also a reported association with Clostridium difficile-associated diarrhea and, in rare cases, fundic gland polyps. If any side effects persist or worsen, consult your doctor.

Is ISAZ D CAP safe during pregnancy or breastfeeding?

During pregnancy, ISAZ D CAP may be considered unsafe, as animal studies have indicated potential harmful effects on the developing baby, although human studies are limited. Your doctor will weigh the benefits against any potential risks before prescribing it.

Regarding breastfeeding, there is conflicting information. Some sources suggest that the drug may not pass into breastmilk in significant amounts and might not be harmful to the baby, while others advise against breastfeeding while using Domperidone or state that ISAZ D CAP is unsafe during breastfeeding. Therefore, it is crucial to consult your doctor if you are pregnant or breastfeeding to determine the safest course of action.

Can ISAZ D CAP be taken with other medications?

ISAZ D CAP can interact with several medications. It should be used with caution or avoided with:

• CYP3A4 inhibitors: such as ketoconazole, itraconazole, clarithromycin, and erythromycin, as they can increase the risk of QT prolongation.
• pH-dependent medications: such as digoxin, ketoconazole, and iron salts, as its effect on stomach acid levels can alter their absorption.
• Antiplatelet medicines: like clopidogrel, as it may reduce their blood-thinning effect.
• HIV medicines: including atazanavir, nelfinavir, ritonavir, and saquinavir, as ISAZ D CAP might affect their absorption or reduce their effectiveness.
• Other drugs: such as bromocriptine, certain heart medications (especially those for irregular heartbeat), MAOI antidepressants (e.g., phenelzine, isocarboxazid), other mood medicines (e.g., mesoridazine, thioridazine), painkillers (e.g., codeine, morphine), erlotinib, and methotrexate.

Always inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken?

You should inform your doctor if you have kidney or liver disease, as dose adjustments may be needed, and the medicine is generally not recommended for moderate to severe liver disease. Caution is also advised for individuals with heart conditions, such as QT prolongation or cardiac arrhythmias, or a prolactin-releasing pituitary tumor (prolactinoma).

Avoid consuming alcohol while taking ISAZ D CAP, as it can increase stomach acid production and worsen acidity/heartburn. The medication may cause decreased alertness, affected vision, sleepiness, or dizziness, so avoid driving or operating machinery until you know how it affects you. ISAZ D CAP is not recommended for children as its safety has not been established. Long-term use requires monitoring for potential risks like low magnesium/B12 levels and bone fractures. Inform your doctor if you have stomach problems like bleeding or intestinal blockage.

What happens if a dose is missed?

If you miss a dose of ISAZ D CAP, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.

How should it be stored?

ISAZ D CAP should be stored in its original container, tightly closed, at room temperature (ideally between 15°C and 30°C). Protect the medicine from direct sunlight and moisture to maintain its efficacy. Always keep it out of sight and reach of children.