Egolix 150 Mg

EGOLIX 150 MG

EGOLIX 150 MG is a prescription medication designed for the management of moderate to severe pain associated with endometriosis. It is manufactured by Sun Pharmaceutical Industries Ltd..

• Name:

  • Brand Name: EGOLIX
  • Common Name: Elagolix (also marketed under Orilissa, Endoreg in some regions)

• Composition: Each film-coated tablet contains Elagolix Sodium INN equivalent to 150 mg of Elagolix.

• Uses: EGOLIX is indicated for the management of moderate to severe pain associated with endometriosis. This includes symptoms such as pelvic pain, menstrual cramps, and pain during intercourse (dyspareunia). It works as a GnRH receptor antagonist, suppressing luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn lowers estrogen and progesterone levels, thus reducing endometrial tissue growth and associated pain.

• Dosage and Administration: Pregnancy should be excluded before starting EGOLIX, and treatment should begin within 7 days from the onset of menses. EGOLIX 150 mg is typically taken once daily, with or without food, for up to 24 months. For patients with moderate hepatic impairment, treatment duration should be limited to 6 months.

• Side Effects: Common side effects include hot flushes, night sweats, headache, nausea, insomnia, amenorrhea (absence of menstrual periods), anxiety, arthralgia (joint pain), mood changes, and bone loss. Serious side effects can include elevated hepatic transaminase, new onset or worsening depression, and suicidal ideation.

• Precautions: EGOLIX is contraindicated in pregnant women due to the risk of early pregnancy loss. It is also contraindicated in individuals with known osteoporosis or severe hepatic impairment, and with concomitant use of strong OATP1B1 inhibitors (e.g., cyclosporine, gemfibrozil). The medication can cause dose and duration-dependent decreases in bone mineral density that may not be completely reversible. It may also alter menstrual bleeding, making it harder to recognize pregnancy, thus non-hormonal contraception is recommended during treatment and for one week after discontinuation. Patients should be monitored for mood changes, depression, and suicidal thoughts.

• Storage: Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Here are the most frequently asked questions about EGOLIX 150 MG:

What is EGOLIX 150 MG used for?

EGOLIX 150 MG is used for the management of moderate to severe pain associated with endometriosis, including pelvic pain, menstrual cramps, and pain during sexual intercourse (dyspareunia).

How does EGOLIX 150 MG work?

EGOLIX 150 MG contains Elagolix, which is a gonadotropin-releasing hormone (GnRH) receptor antagonist. It works by inhibiting GnRH signaling in the pituitary gland, leading to a dose-dependent reduction in the blood concentrations of ovarian sex hormones like estradiol and progesterone. This action helps to reduce the growth and activity of endometrial tissue, thereby relieving pain.

What is the usual dosage of EGOLIX 150 MG?

The typical initial dosage for EGOLIX 150 MG is one tablet (150 mg) once daily for up to 24 months. It should be taken at approximately the same time each day, with or without food. For patients with moderate hepatic impairment, the treatment duration is limited to 6 months.

What are the possible side effects of EGOLIX 150 MG?

Common side effects can include hot flushes, night sweats, headache, nausea, insomnia (difficulty sleeping), amenorrhea (absence of menstrual periods), anxiety, arthralgia (joint pain), mood changes, bone loss, and elevated hepatic transaminase. Some users may also experience depression or suicidal thoughts, and it is important to seek medical attention if such symptoms occur.

Is EGOLIX 150 MG safe during pregnancy or breastfeeding?

EGOLIX 150 MG is contraindicated in pregnant women because exposure to Elagolix early in pregnancy may increase the risk of early pregnancy loss. Non-hormonal contraception is recommended during treatment and for at least one week after discontinuing the medication. There is limited information on whether Elagolix or its metabolites are present in human milk or their effects on breastfed infants, so it is advisable to consult a doctor before using this medicine while breastfeeding.

Can EGOLIX 150 MG be taken with other medications?

EGOLIX 150 MG can interact with other medications. It is contraindicated with strong organic anion transporting polypeptide (OATP1B1) inhibitors such as cyclosporine and gemfibrozil. Estrogen-containing contraceptives are expected to reduce the efficacy of Elagolix, and non-hormonal contraception should be used. It may also affect the levels of certain other drugs, such as P-gp substrates (e.g., digoxin), CYP2C19 substrates (e.g., omeprazole), and CYP3A substrates (e.g., oral midazolam, rosuvastatin). Strong CYP3A inhibitors and rifampin may also require limitations on the duration of Elagolix treatment.

What precautions should be taken while on EGOLIX 150 MG?

Significant precautions include the risk of dose and duration-dependent decreases in bone mineral density (bone loss), which may not be fully reversible. EGOLIX may also alter menstrual bleeding, which can make it harder to recognize a pregnancy; therefore, pregnancy tests are crucial if pregnancy is suspected. Patients should be monitored for new or worsening mood changes, depression, anxiety, or suicidal ideation. It is also contraindicated in individuals with known osteoporosis or severe hepatic impairment.

What happens if a dose of EGOLIX 150 MG is missed?

If you miss a dose of EGOLIX 150 MG, take it as soon as you remember on the same day. Afterwards, resume your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should EGOLIX 150 MG be stored?

EGOLIX 150 MG tablets should be stored below 30°C in a dry place, protected from light and moisture. Always keep all medicines out of the reach of children.