Cremagel ( For Pain Relief & Healing In Anal Fissures

CREMAGEL

Name: Cremagel (Brand Name by Abbott) Composition: Diltiazem (2% w/w)

Uses: Cremagel is a topical medication primarily prescribed for the treatment of anal fissures, which are small tears in the lining of the anus. Its active ingredient, Diltiazem, works as a calcium channel blocker to relax the smooth muscles around the anus, thereby reducing anal pressure and promoting increased blood flow to the affected area. This action helps to alleviate pain, irritation, and itching associated with anal fissures, facilitating wound healing.

Dosage and Administration: Cremagel is for external use only.

• Clean and dry the affected area thoroughly before application.
• Apply a small amount of the gel gently over the affected area.
• It is typically advised to use it twice daily or as directed by a healthcare professional.
• For rectal use, a rectal applicator may be attached to the tube, inserted gently, and the medication squeezed while withdrawing.
• Apply with clean hands, using a finger cot or disposable glove, especially after a bowel movement and gentle cleansing, to ensure proper dosing and avoid contamination.
• Avoid contact with eyes, mouth, nose, ears, and vagina. In case of accidental contact, rinse thoroughly with water.

Side Effects: Common side effects of Cremagel may include:

• Application site reactions such as burning, irritation, itching, and redness.
• Headache.
• Dizziness or lightheadedness.
• Rectal bleeding (less common). More serious, though rare, skin reactions like Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and exfoliative dermatitis have been reported with diltiazem and should prompt immediate medical consultation if symptoms occur.

Precautions:

• Pregnancy: Cremagel is generally considered unsafe for use during pregnancy as there is evidence of risk to the developing baby. Consult a doctor.
• Breastfeeding: Use with caution during breastfeeding. It is advisable to consult a doctor, as limited human data suggests the drug may not represent a significant risk, but some sources recommend holding breastfeeding until the drug is eliminated.
• Allergies: Do not use if you have a known allergy to Diltiazem or any other ingredients in Cremagel.
• Medical Conditions: Use with caution in patients with heart conditions such as heart failure or bradycardia, as it may worsen symptoms. Limited information is available for use in kidney and liver disease; consult a doctor.
• Interactions: Inform your doctor about all current medications to avoid potential interactions, although systemic absorption is low due to external use.
• Avoid using on open wounds or bleeding hemorrhoids unless specifically directed by a doctor.
• Limit physical exercises, standing, and prolonged sitting while on medication.
• Do not exceed the recommended dosage.

Storage: Store Cremagel below 25°C. Keep in a cool and dry place, away from sunlight. Do not freeze. Keep out of reach of children.

Here are frequently asked questions about CREMAGEL (Diltiazem 2% w/w) for pain relief and healing in anal fissures by Abbott:

What is CREMAGEL used for?

CREMAGEL is a gel formulation primarily used for the treatment of anal fissures, which are small tears in the lining of the anal canal. It helps to relieve pain, reduce anal spasms, and promote the healing of these tears.

How does CREMAGEL work?

CREMAGEL contains Diltiazem, which is a calcium channel blocker. It works by relaxing the muscles around the anus, specifically the anal sphincter. This action helps to reduce anal pressure and improve blood flow to the affected area, thereby reducing pain and promoting the healing process of the anal fissure.

What is the usual dosage of CREMAGEL?

The typical dosage involves cleaning the affected area and applying a thin layer of the gel to the anal area twice daily, or as directed by your doctor. It should be gently massaged into the skin until absorbed.

What are the possible side effects of CREMAGEL?

Common side effects may include headache, dizziness, and skin irritation at the application site, such as a burning sensation, itching, redness, or rashes. Rectal bleeding has also been reported as a less common side effect. If any side effects persist or worsen, consult your doctor.

Is CREMAGEL safe during pregnancy or breastfeeding?

CREMAGEL should be used with caution during both pregnancy and breastfeeding. It is essential to consult your doctor before using this medicine, as they will evaluate the potential benefits against any possible risks.

Can CREMAGEL be taken with other medications?

While CREMAGEL is applied topically, it is always advisable to inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions. Although topical application generally leads to low systemic absorption, some interactions have been noted with certain oral medications like those used for erectile dysfunction, blood clot management, migraine, and high blood pressure.

What precautions should be taken while using CREMAGEL?

CREMAGEL is for external use only. Avoid contact with your eyes, mouth, nose, and any open wounds. Wash your hands thoroughly before and after applying the gel. Do not apply it on broken or infected skin. If you have a known allergy to diltiazem, you should avoid using this product. Caution is also advised for elderly patients, children, and individuals with pre-existing heart, liver, or kidney conditions. Since it may cause light-headedness or dizziness, it is recommended not to drive or operate heavy machinery until you are mentally alert.

What happens if a dose of CREMAGEL is missed?

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply a double dose to compensate for the missed one.

How should CREMAGEL be stored?

CREMAGEL should be stored in a cool, dry place, typically below 25°C. It should not be frozen and must be kept out of the reach of children.