Dubinor Tablet

DUBINOR TABLET by INTEGRACE PVT LTD

Name

Brand Name: Dubinor Tablet

Composition

DUBINOR TABLET is a combination medicine containing three active ingredients:

• Methylcobalamin (1500 mcg): A form of Vitamin B12, essential for nerve health, aiding in the production of myelin (a substance that protects nerve fibers) and regenerating damaged nerve cells.
• Nortriptyline (10 mg): A tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) in the brain, thereby reducing pain signals.
• Pregabalin (75 mg): An anticonvulsant that reduces pain by interfering with pain messages traveling through the brain and down the spine. It modulates calcium channel activity of nerve cells.

Uses

Dubinor Tablet is primarily prescribed for the management of neuropathic pain. This includes conditions such as:

• Diabetic neuropathy/Diabetic peripheral neuropathic pain.
• Postherpetic neuralgia (nerve pain after shingles infection).
• Neuropathic pain associated with spinal cord injury. It also helps to manage nutritional deficiencies and provides a protective effect on nerve tissues and the brain.

Dosage and Administration

Take DUBINOR TABLET as prescribed by your doctor. It should be swallowed whole with water and not crushed, broken, or chewed. It can be taken with or without food, but it is advisable to take it at a fixed time each day to maintain consistent medicine levels. The typical recommended adult dose is 75 mg, taken once or twice daily, with a maximum daily dosage of 150 mg, adjusted based on the condition's severity and patient response. Do not stop taking the medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.

Side Effects

Common side effects may include:

• Dizziness
• Sleepiness/Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Stomach upset
• Blurred vision/Loss of vision
• Dry mouth
• Weight gain
• Constipation
• Tiredness/Fatigue
• Peripheral oedema (swelling of lower legs and hands)

Serious side effects, though less common, can include irregular heartbeats, severe drowsiness, confusion, hallucinations, agitation, stiff muscles, seizures, or coma in overdose situations.

Precautions

• Allergies: Do not take if you are allergic to any of its ingredients.
• Pregnancy & Breastfeeding: Consult your doctor before taking if pregnant or breastfeeding, as limited studies have been done, and it's generally not advised unless benefits outweigh risks.
• Alcohol: Avoid consuming alcohol, as it may increase dizziness and sleepiness.
• Driving & Machinery: Dubinor Tablet may cause drowsiness, dizziness, and blurred vision; therefore, avoid driving or operating heavy machinery until you know how the medication affects you.
• Medical Conditions: Inform your doctor if you have liver or kidney issues, heart problems, diabetes, thyroid problems, or a history of seizures.
• Suicidal Thoughts: Report any unusual changes in mood or behavior, worsening depression, or suicidal thoughts to your doctor immediately.
• Children: Safety and effectiveness have not been established in children.
• Interactions: Inform your doctor about all other medicines and supplements you are taking to avoid potential drug interactions.

Storage

Store DUBINOR TABLET in its original packaging at room temperature in a clean and dry place. Protect it from moisture and light. Keep this medication out of the sight and reach of children. Dispose of expired or unused medication properly.

What is Dubinor Tablet used for?

Dubinor Tablet is primarily used to manage neuropathic pain, which is pain caused by nerve damage. This includes conditions such as diabetic peripheral neuropathy, postherpetic neuralgia (nerve pain after shingles), and pain associated with spinal cord injury. It also helps in producing red blood cells and supports nerve function.

How does Dubinor Tablet work?

Dubinor Tablet is a combination of three active ingredients: Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin, a form of Vitamin B12, helps in the production of myelin (a substance that protects nerve fibers) and regenerates damaged nerve cells. Nortriptyline, a tricyclic antidepressant, works by increasing the levels of chemical messengers like serotonin and noradrenaline in the brain, which helps reduce pain signals and regulate mood. Pregabalin, an anticonvulsant, reduces pain by modulating calcium channel activity in nerve cells and interfering with pain messages traveling through the brain and spinal cord.

What is the usual dosage of Dubinor Tablet?

The usual starting dosage is one tablet at bedtime. If the response is not adequate, your doctor may increase it to twice daily. It should be taken as prescribed by your doctor, swallowed whole with water, and not crushed or chewed. It can be taken with or without food, but it is best to take it at a fixed time each day to maintain a consistent level of medicine in your body.

What are the possible side effects of Dubinor Tablet?

Common side effects include dizziness, sleepiness, trouble concentrating, blurred vision, dry mouth, weight gain, swelling of the hands or feet, constipation, nausea, headache, difficulty in urination, weakness, confusion, increased heart rate, and decreased sexual desire. More serious but rare side effects can include hypersensitivity or allergic reactions (like skin rash, blisters, hives, difficulty breathing), angioedema (swelling of the face, lips, or tongue), and suicidal thoughts or actions. If you experience any severe or persistent side effects, contact your doctor immediately.

Is Dubinor Tablet safe during pregnancy or breastfeeding?

Dubinor Tablet is generally not recommended for use during pregnancy or breastfeeding. Limited studies suggest it may have adverse effects on the fetus, and its components may pass into breast milk. Always consult your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medicine.

Can Dubinor Tablet be taken with other medications?

Dubinor Tablet can interact with various medications. It is crucial to inform your doctor about all other medicines, supplements, or herbal products you are currently taking to avoid potential interactions. Specific interactions can occur with:

• Opioid analgesics: Such as oxycodone and tramadol.
• Antidepressants: Including MAO inhibitors, sertraline, and other medications for depression and anxiety (e.g., lorazepam, diazepam).
• Medicines for gastroesophageal reflux: Such as cimetidine and ranitidine.
• Oral contraceptives.
• Certain cancer chemotherapy medicines.
• Antihypertensives: Like reserpine, which may increase the effect of Dubinor.
• Non-opioid analgesics: Such as acetaminophen, which may decrease the effect of Dubinor.
• Alcohol: Avoid alcohol consumption as it can increase side effects like dizziness, drowsiness, and impaired thinking.

What precautions should be taken while taking Dubinor Tablet?

You should avoid consuming alcohol while on this medication. Due to potential dizziness, sleepiness, or blurred vision, do not drive or operate heavy machinery until you know how the medicine affects you. Inform your doctor if you have liver, kidney, or heart problems, diabetes, thyroid problems, angioedema, or a history of seizures. It is important not to stop taking Dubinor Tablet suddenly without consulting your doctor, as this can lead to withdrawal symptoms. Also, report any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts to your doctor immediately.

What happens if a dose of Dubinor Tablet is missed?

If you miss a dose of Dubinor Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

How should Dubinor Tablet be stored?

Dubinor Tablet should be stored at room temperature, ideally below 30°C. Keep it in its original packaging, protected from moisture and light. Ensure the medicine is kept out of reach of children and pets.