Stalix D (10+50) Tablet

STALIX D (10+50) Tablet is a combination medication manufactured by Torrent Pharmaceuticals Ltd., primarily used in the management of Type 2 diabetes mellitus. It is particularly prescribed for adults whose blood sugar levels are not adequately controlled with diet and exercise alone, or with metformin monotherapy.

• Name: STALIX D (10+50) TABLET
• Composition: Each tablet contains Dapagliflozin 10 mg and Sitagliptin 50 mg.
• Uses:
  • Manages high blood sugar levels in adults with Type 2 diabetes mellitus.
  • Improves blood sugar control and proper utilization of insulin.
  • Reduces the risk of diabetes-related complications such as kidney damage, nerve problems, and eyesight loss.
  • May lower the risk of heart attack, heart failure, and other cardiovascular events.
  • Also used to treat chronic kidney disease in adults with reduced kidney function.
• Dosage and Administration:
  • Typically taken orally once daily, or as directed by a physician.
  • Can be taken with or without food, but consistency in timing each day is recommended.
  • Swallow the tablet whole with water; do not crush, chew, or break it.
  • Do not stop taking the medication without consulting a doctor.
• Side Effects:
  • Common: Urinary tract infections (UTIs), genital fungal infections, nasopharyngitis (common cold symptoms), upper respiratory tract infection, headache, diarrhea, nausea, vomiting, stomach pain, flatulence, constipation, increased urination, and dehydration.
  • Serious: Inflammation of the pancreas (pancreatitis), severe allergic reactions, necrotizing fasciitis of the perineum (Fournier's gangrene), diabetic ketoacidosis, and severe hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines.
• Precautions:
  • Not recommended for Type 1 diabetes or diabetic ketoacidosis.
  • Inform your doctor about any kidney or liver problems, urinary tract infections, heart failure, gallstones, pancreatitis, alcohol dependence, or high triglyceride levels.
  • Use with caution in pregnant or breastfeeding women; consult a doctor.
  • Avoid excessive alcohol intake.
  • Regular monitoring of kidney function and blood sugar levels is recommended.
  • May cause dizziness or sleepiness; use caution when driving or operating machinery.
• Storage: Store in a cool and dry place, below 30°C, protected from light, and out of the sight and reach of children.

What is STALIX D (10+50) Tablet used for?

STALIX D (10+50) Tablet is a combination medicine primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed when blood sugar levels are not adequately controlled by metformin alone, or in conjunction with diet and exercise. It also helps in preventing serious complications of diabetes such as kidney damage, nerve damage, eyesight loss, and may reduce the risk of heart attack, heart failure, or other cardiovascular events.

How does STALIX D (10+50) Tablet work?

STALIX D (10+50) Tablet contains two active ingredients: Dapagliflozin (10mg) and Sitagliptin (50mg).

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor. It works by blocking a specific protein in the kidneys that is responsible for reabsorbing glucose from the urine back into the blood. This action increases the removal of sugar through the urine, thereby reducing blood glucose levels.
• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by indirectly increasing the activity of certain natural chemicals (incretin hormones) in the body, such as GLP-1 and GIP. These hormones help regulate blood sugar by stimulating insulin release, especially after meals, and decreasing the amount of sugar produced by the liver.

What is the usual dosage of STALIX D (10+50) Tablet?

STALIX D (10+50) Tablet should be taken exactly as directed by your doctor. It is usually taken orally once daily, and can be taken with or without food. It is recommended to take the tablet at the same time each day for optimal benefits. Do not cut, break, or chew the medicine, and do not exceed the prescribed dose. Your doctor will determine the appropriate dosage based on your medical condition and response to treatment.

What are the possible side effects of STALIX D (10+50) Tablet?

Common side effects include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, headache, diarrhea, nausea, and vomiting. Some individuals might also experience fungal infections in the genital area. Other possible side effects can include low blood sugar (hypoglycemia), especially when used with other anti-diabetic medicines, and dehydration.

Is STALIX D (10+50) Tablet safe during pregnancy or breastfeeding?

There is limited information on the effect of STALIX D (10+50) Tablet in pregnant women, so it should not be used during pregnancy unless considered clearly necessary and prescribed by a doctor. Similarly, no information is available if it passes into human breast milk, so it should not be used by breastfeeding women. Always inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medication.

Can STALIX D (10+50) Tablet be taken with other medications?

Yes, STALIX D (10+50) Tablet can interact with other medications. It's crucial to inform your doctor about all other medicines, herbals, or supplements you are currently taking or might take to avoid potential interactions. Particular care should be taken if you are using:

• Other anti-diabetic medicines like insulin or sulfonylureas, as this can increase the risk of extremely low blood sugar levels (hypoglycemia).
• Diuretics (water pills) such as furosemide and hydrochlorothiazide, as this may increase the risk of dehydration and low blood pressure.
• Medicines for fungal infections (e.g., ketoconazole, itraconazole), bacterial infections (e.g., clarithromycin), or HIV/AIDS (e.g., ritonavir).
• Medicines for heart failure (e.g., digoxin).
• Nonsteroidal Anti-inflammatory Drugs (NSAIDs) like ibuprofen or naproxen, which could increase the risk of kidney problems.

What precautions should be taken?

Before taking STALIX D (10+50) Tablet, discuss your medical history with your doctor, especially if you have:

• Type 1 diabetes or diabetic ketoacidosis.
• Kidney disease, severe kidney impairment, or are on dialysis.
• Liver disease or heart failure.
• A history of pancreatitis or gallstones.
• A history of low blood pressure or are elderly (≥ 65 years).
• Any stomach or intestine illness. It is important to drink plenty of fluids to prevent dehydration and practice good hygiene to prevent genital fungal and urinary tract infections. Avoid excessive alcohol consumption as it can interfere with blood sugar control and increase the risk of side effects like diabetic ketoacidosis or hypoglycemia. Regular monitoring of blood sugar levels is crucial while on this medication. Do not stop taking the medication without consulting your doctor, as abrupt discontinuation can lead to increased sugar levels and a higher risk of diabetes complications.

What happens if a dose is missed?

If you miss a dose of STALIX D (10+50) Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

STALIX D (10+50) Tablet should be stored in a cool and dry place, away from moisture and direct sunlight. It should be kept out of the sight and reach of children. The recommended storage temperature is usually below 30°C or between 10ºC to 25ºC.