Botropase Inj 2ml

BOTROPASE INJ 2ML

Botropase Injection 2ML is a haemostatic agent manufactured by Juggat Pharma (Jagdale Industries Pvt. Ltd.) used to control and prevent bleeding.

• Name

  • Common Name: Botropase Injection
  • Brand Name: Botropase INJ 2ML

• Composition

  • Active Ingredient: Haemocoagulase (1 IU or 1 CU). Haemocoagulase is derived from the venom of Bothrops Jararaca or Bothrops atrox snakes. It functions by promoting blood clot formation, similar to thrombin and thromboplastin, converting fibrinogen into fibrin, and accelerating platelet clumping.

• Uses Botropase Injection is primarily used to stop or control bleeding by speeding up the process of clot formation. It is effective in managing bleeding in various medical and surgical scenarios, including:

  • During or after surgery.
  • Dental procedures, such as tooth extraction.
  • Traumatic bleeding.
  • Gynecological cases.
  • Oral bleeding.
  • Pulmonary bleeding (pulmonary haemorrhage).
  • Capillary bleeding during cleft-palate surgery and skin grafting procedures.
  • Internal and external haemorrhages.

• Dosage and Administration Botropase Injection is administered by a doctor or a nurse. It should not be self-administered at home. The dosage and frequency depend on the severity of the condition and the patient's response to management. It can be administered either intramuscularly or intravenously.

• Side Effects

  • Common Side Effects:
    • Injection site reactions such as pain, redness, and swelling.
    • Allergic reactions (e.g., rash, itching, difficulty breathing, swelling of the face and throat).
    • Dizziness.
  • Serious Side Effects (Rare):
    • Severe allergic reactions.
    • Blood clot formation (increased risk of abnormal clots).
    • Chest pain.
    • Difficulty breathing.
    • Swelling in the legs. Immediate medical attention is required if these serious side effects occur.

• Precautions

  • Individuals should not take Botropase Injection if they have known allergies to haemocoagulase or similar medicines.
  • It is not recommended for people with clotting disorders such as thrombosis, embolism, or disseminated intravascular coagulation (DIC).
  • Caution is advised for patients with severe heart, liver, or kidney problems, as these conditions can affect how the medicine works.
  • It should not be given to patients who already have blood clots, as it may worsen the condition.
  • Pregnant and breastfeeding women should consult a doctor before use, as it may not be recommended.
  • Used cautiously in elderly or pediatric populations.

• Storage Store Botropase Injection below 25°C or between 10°C to 25°C (non-cold chain). It should be kept in a cool, dry place, away from direct sunlight, and out of reach of children. Always check the expiry date before use.

Here are some frequently asked questions about BOTROPASE INJ 2ML:

What is BOTROPASE INJ 2ML used for?

BOTROPASE INJ 2ML is primarily used to manage bleeding disorders and control bleeding during and after various surgical procedures. This includes situations like tooth extractions, cleft-palate surgeries, skin grafting, post-extraction bleeding in patients with hemophilia, and bleeding in cardiac patients who are taking aspirin. It helps to stop bleeding and prevent complications associated with excessive blood loss.

How does BOTROPASE INJ 2ML work?

BOTROPASE INJ 2ML contains Haemocoagulase, an enzyme derived from snake venom (Bothrops Jararaca or Bothropsatrox). It works by promoting blood clot formation, similar to thrombin and thromboplastin. It converts fibrinogen into fibrin, which are crucial components for forming blood clots. It also accelerates the clumping of platelets and reduces capillary permeability at the site of injury, thereby reducing bleeding and coagulation time.

What is the usual dosage of BOTROPASE INJ 2ML?

The dosage of BOTROPASE INJ 2ML is typically 1-2 units (1-2 ml) and is administered either intramuscularly (IM) or intravenously (IV). For prophylactic use before surgery, it might be given 30 minutes to 1 hour prior. Therapeutically, it can be repeated every 6 to 8 hours until the desired effect is achieved, or even every 30 minutes in emergencies. The maximum daily dose should not exceed 5 ml (5 KU). The exact dosage depends on the severity of the condition and should be determined by a doctor.

What are the possible side effects of BOTROPASE INJ 2ML?

Common side effects include allergic reactions (such as rash, itching, or difficulty breathing), redness, swelling, or pain at the injection site, and dizziness. Serious but rare side effects can include severe allergic reactions, blood clot formation, chest pain, difficulty breathing, or swelling in the legs, which require immediate medical attention.

Is BOTROPASE INJ 2ML safe during pregnancy or breastfeeding?

The safety of BOTROPASE INJ 2ML during pregnancy has not been established, and it is not known whether the medication passes into breast milk. Therefore, it is advisable to consult a doctor before using this medication if you are pregnant or breastfeeding.

Can BOTROPASE INJ 2ML be taken with other medications?

BOTROPASE INJ 2ML can interact with certain medications. It may interact with anticoagulants (like warfarin, heparin), nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, platelet aggregation inhibitors (like aspirin, clopidogrel), and thrombolytics (such as alteplase, reteplase). It has also been noted to interact with Reserpine, Sulfadimethoxine, and Testosterone. It is important to inform your doctor about all other medications you are taking.

What precautions should be taken with BOTROPASE INJ 2ML?

BOTROPASE INJ 2ML should be used with caution in individuals with a history of bleeding disorders, severe liver or kidney problems, or known allergies to hemocoagulase. It is contraindicated in patients with existing clotting disorders like thrombosis, embolism, or disseminated intravascular coagulation (DIC), as it can worsen these conditions and increase the risk of dangerous complications. Alcohol consumption should be avoided while using this medicine.

What happens if a dose of BOTROPASE INJ 2ML is missed?

If a dose of BOTROPASE INJ 2ML is missed, you should contact your healthcare provider for guidance. It is important not to double up on doses to make up for a missed one unless specifically instructed by your doctor.

How should BOTROPASE INJ 2ML be stored?

BOTROPASE INJ 2ML should be stored in a cool and dry place, protected from direct sunlight, and kept out of the reach of children. It is generally recommended to store it below 30°C or between 10°C and 25°C. Always check the expiry date before use.