Izra-d 40 Capsules

IZRA-D 40 CAPSULES

IZRA-D 40 CAPSULES, manufactured by Torrent Pharmaceuticals Ltd, is a prescription medication designed to manage various gastrointestinal conditions. It is available as sustained-release capsules.

Composition Each capsule of IZRA-D 40 contains a combination of two active ingredients:

• Esomeprazole: 40 mg (a proton pump inhibitor)
• Domperidone: 30 mg (a prokinetic agent)

Uses IZRA-D 40 CAPSULES are primarily used for the treatment and management of:

• Gastroesophageal Reflux Disease (GERD), also known as acid reflux.
• Symptoms associated with GERD, such as heartburn, acidity, stomach pain, and irritation.
• Healing of stomach (gastric) and duodenal ulcers.
• Zollinger-Ellison syndrome and other conditions involving excessive stomach acid production.
• Relief from nausea and vomiting.
• Indigestion (dyspepsia).

Dosage and Administration IZRA-D 40 CAPSULES should be taken orally, swallowed whole with a glass of water, and should not be chewed, crushed, or broken. It is most effective when taken on an empty stomach, ideally 30 minutes to 1 hour before a meal, preferably in the morning. The exact dose and duration of treatment will be determined by a healthcare professional based on the patient's medical condition and response to the medicine.

Side Effects Commonly reported side effects include:

• Diarrhea
• Flatulence
• Stomach pain
• Dryness in the mouth
• Headache
• Nausea
• Dizziness and sleepiness
• Constipation

Long-term use may lead to a decrease in magnesium and vitamin B12 levels, and may increase the risk of bone fractures and certain bacterial infections.

Precautions

• Allergies: Do not take if allergic to esomeprazole, domperidone, or any other ingredients in the capsule.
• Pregnancy and Breastfeeding: Consult a doctor. The medicine may be unsafe to use during pregnancy and is considered unsafe during breastfeeding as it passes into breast milk.
• Driving and Operating Machinery: Avoid activities requiring mental focus if dizziness or sleepiness occurs.
• Alcohol: Exercise caution with alcohol consumption as it can increase drowsiness and may elevate stomach acid production.
• Medical Conditions: Inform your doctor if you have severe kidney disease, severe liver disease, heart problems (especially those causing QT prolongation), a pituitary tumor (prolactinoma), a blockage or tear in the intestine, bleeding in the digestive system, gastric cancer, low magnesium or vitamin B12 levels, or osteoporosis.
• Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, as IZRA-D 40 can interact with various medicines like certain antifungals, antibiotics, blood thinners, cardiac medications, and anti-cancer drugs.
• Diet and Lifestyle: Avoid caffeine-containing beverages, spicy/deep-fried/processed foods, carbonated drinks, and acidic foods as they can worsen symptoms.
• Pediatric Use: The safety and efficacy of IZRA-D 40 in children under 18 years of age have not been established.

Storage Store IZRA-D 40 CAPSULES in a cool and dry place, protected from direct sunlight and moisture. The ideal storage temperature is below 25°C or 30°C. Keep this medicine out of the reach and sight of children and pets.

What is IZRA-D 40 CAPSULES used for?

IZRA-D 40 CAPSULES is primarily used to treat gastroesophageal reflux disease (GERD), a condition where stomach acid flows back into the food pipe, causing symptoms like heartburn, chest discomfort, and acidity. It is also effective in managing stomach and duodenal ulcers, Zollinger-Ellison syndrome (a condition with excessive stomach acid production), and provides relief from general acidity and indigestion.

How does IZRA-D 40 CAPSULES work?

IZRA-D 40 CAPSULES works through the combined action of its two active ingredients: Esomeprazole and Domperidone. Esomeprazole is a proton pump inhibitor (PPI) that reduces the production of stomach acid by blocking a pump responsible for acid secretion on the stomach wall. Domperidone is a prokinetic agent that increases the movement and contractions of the stomach and intestines. This action helps food move more easily through the digestive system and prevents acid from flowing back into the esophagus.

What is the usual dosage and how should it be taken?

IZRA-D 40 CAPSULES should be taken at least one hour before meals, preferably in the morning, or as directed by your doctor. The capsules should be swallowed whole with water and should not be crushed, chewed, or opened. The exact dosage and duration of treatment will depend on your specific medical condition and response to the medicine, and should not be altered without consulting your doctor.

What are the possible side effects of IZRA-D 40 CAPSULES?

Common side effects of IZRA-D 40 CAPSULES include headache, dizziness, stomach pain, diarrhea, dry mouth, nausea, and flatulence. Most of these side effects are temporary and usually resolve over time. If you experience any persistent or severe side effects, it is important to consult your doctor.

Is IZRA-D 40 CAPSULES safe during pregnancy or breastfeeding?

IZRA-D 40 CAPSULES should generally be avoided during pregnancy as there is limited information regarding its safety in human pregnancy, and animal studies suggest potential harm to the developing baby. It is also not recommended during breastfeeding as it passes into breast milk in small amounts and might affect the baby. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, to assess the benefits and risks.

Can IZRA-D 40 CAPSULES be taken with other medications?

IZRA-D 40 CAPSULES can interact with certain medicines, affecting how they work or being affected itself. It is crucial to inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medicines, and herbal supplements. Specific interactions have been noted with anti-HIV medications (like rilpivirine, nelfinavir), disopyramide (for irregular heartbeats), certain antibiotics (like clarithromycin, erythromycin, moxifloxacin), antifungals (like ketoconazole, itraconazole), medicines for mental problems (like diazepam, phenytoin), digoxin (for heart failure), blood thinners (like clopidogrel, warfarin), and methotrexate (an anti-cancer medication).

What precautions should be taken while using IZRA-D 40 CAPSULES?

Several precautions should be considered:

• Liver and Kidney Conditions: Use with caution in patients with kidney disease, and it is not recommended for those with severe liver disease.
• Heart Problems: Caution is advised for patients with existing heart conditions due to the risk of QT prolongation associated with domperidone.
• Long-term Use: Prolonged use (more than three months) may lead to decreased blood magnesium levels and an increased risk of bone fractures. It can also reduce vitamin B12 absorption. Regular monitoring and supplements may be advised by your doctor.
• Alcohol Consumption: Avoid or limit alcohol consumption as it can increase acidity and worsen symptoms, and may also increase drowsiness.
• Driving: This medicine may cause dizziness or sleepiness, so avoid driving or operating machinery if you feel unwell or cannot be alert.
• Other Conditions: Inform your doctor if you have a history of pituitary gland tumors (prolactinoma), blockage or bleeding in the digestive system, or are undergoing specific blood tests (e.g., Chromogranin A).

What happens if a dose of IZRA-D 40 CAPSULES is missed?

If you miss a dose of IZRA-D 40 CAPSULES, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should IZRA-D 40 CAPSULES be stored?

IZRA-D 40 CAPSULES should be stored below 25°C or 30°C in a clean and dry place, protected from direct sunlight, moisture, and heat. Keep this medicine out of sight and reach of children and pets.