Glucreta S 5+50 Tab

GLUCRETA S 5+50 TAB

• Name: GLUCRETA S 5/50MG TABLET. The brand name is GLUCRETA S, manufactured by Torrent Pharmaceuticals Ltd.

• Composition: Each tablet contains a combination of Dapagliflozin 5 mg and Sitagliptin 50 mg. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.

• Uses: GLUCRETA S 5+50 TAB is primarily used to manage Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels, especially when diet and exercise alone are insufficient. The medication works to prevent serious diabetes complications like kidney damage, blindness, nerve problems, and loss of limbs. It may also reduce the risk of heart attack, heart failure, or other cardiovascular events in some patients.

• Dosage and Administration: This medicine is typically taken orally, once or twice daily. It can be taken with or without food, but it is often recommended to take it with meals to minimize gastrointestinal side effects. Tablets should be swallowed whole and not crushed or chewed. Dosage is determined by a doctor based on the patient's medical condition and response to treatment. Consistent daily timing is important for steady blood sugar control.

• Side Effects:

  • Common: Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, hypoglycemia (low blood sugar), upper respiratory tract infection, nasal congestion, sore throat, increased urination, and genital fungal infections.
  • Serious: Lactic acidosis (rare but serious, characterized by muscle pain, trouble breathing, unusual tiredness), acute pancreatitis (severe and persistent stomach pain), and severe allergic reactions (rash, hives, swelling of face/lips/tongue/throat).

• Precautions: Inform your doctor about any kidney or liver problems, heart conditions, or history of pancreatitis. Exercise caution with alcohol consumption. Pregnant or breastfeeding women should consult a doctor before use. Do not stop the medication abruptly without consulting a doctor, as this can elevate blood sugar levels and increase the risk of complications. It is not recommended for Type 1 diabetes.

• Storage: Store GLUCRETA S 5+50 TAB in a cool, dry place, away from direct sunlight and moisture, and out of the reach of children.

Here are frequently asked questions about GLUCRETA S 5+50 TAB, along with concise answers:

What is GLUCRETA S 5+50 TAB used for?

GLUCRETA S 5+50 TAB is primarily used to manage type 2 diabetes mellitus in adults whose blood sugar levels are not adequately controlled by metformin alone. It helps control high blood sugar, prevents serious complications of diabetes like kidney damage, blindness, and nerve problems, and can reduce the risk of heart attack, heart failure, or other cardiovascular events. This medication is typically used alongside a healthy diet and regular exercise.

How does GLUCRETA S 5+50 TAB work?

GLUCRETA S 5+50 TAB is a combination medicine containing Dapagliflozin (5mg) and Sitagliptin (50mg). Dapagliflozin, an SGLT-2 inhibitor, works by blocking a protein in the kidneys (sodium-glucose co-transporter 2), which leads to the removal of excess sugar from the body through urine, thereby lowering blood glucose levels. Sitagliptin, a DPP-4 inhibitor, increases the levels of natural substances called incretin hormones. These hormones stimulate the pancreas to produce more insulin when blood sugar is high and decrease the release of glucagon, a hormone that raises blood sugar levels.

What is the usual dosage for GLUCRETA S 5+50 TAB?

The typical dosage is one tablet, taken once or twice daily, as advised by your doctor. It can be taken with or without food, but it is best to take it consistently at the same time each day to maintain steady blood sugar control. Your doctor will determine the appropriate dosage based on your blood glucose levels and overall health condition.

What are the possible side effects of GLUCRETA S 5+50 TAB?

Common side effects can include urinary tract infections (UTIs), nasal congestion, sore throat, upper respiratory tract infections, headache, dizziness, and genital fungal infections. Other common side effects may include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, stomach pain, loss of appetite, and increased urination. More serious, but rare, side effects that require immediate medical attention include lactic acidosis and acute pancreatitis.

Is GLUCRETA S 5+50 TAB safe during pregnancy or breastfeeding?

GLUCRETA S 5+50 TAB is not recommended for use during pregnancy. If you are pregnant or breastfeeding, or plan to become pregnant, you should consult your doctor before taking this medicine, as it should be used with caution in breastfeeding women, or only if considered clearly necessary.

Can GLUCRETA S 5+50 TAB be taken with other medications?

Yes, but you should inform your doctor about all other medications, herbal products, or supplements you are currently taking or plan to take to avoid potential interactions. Taking GLUCRETA S with insulin or sulfonylureas can increase the risk of low blood sugar. Diuretics may increase the risk of dehydration and low blood pressure. Caution is also advised when taken with NSAIDs, certain antifungals (e.g., ketoconazole), antibacterials (e.g., clarithromycin), antivirals (e.g., ritonavir), immunosuppressants (e.g., ciclosporin), and cardiac glycosides (e.g., digoxin).

What precautions should be taken while using GLUCRETA S 5+50 TAB?

It is important to inform your doctor if you have kidney or liver issues, urinary tract infections, heart problems, a history of pancreatitis, or if you are on dialysis. This medicine is not for type 1 diabetes. You should stay well-hydrated by drinking plenty of fluids to prevent dehydration. Practicing good hygiene can help prevent genital fungal infections. Avoid excessive alcohol consumption. Regular monitoring of your blood sugar levels is crucial, and you should not stop taking the medicine without consulting your doctor.

What happens if a dose of GLUCRETA S 5+50 TAB is missed?

If you miss a dose of GLUCRETA S 5+50 TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should GLUCRETA S 5+50 TAB be stored?

GLUCRETA S 5+50 TAB should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of the reach of children. The typical storage temperature is below 30ºC.