Lupase 10000 Tablet (10 Tab)

LUPASE 10000 TABLET (10 TAB) by LUPIN LTD.

Name: Lupase 10000 Tablet (Brand Name)

Composition:

• Active Ingredient: Pancreatin 150mg
• Pancreatin is a blend of digestive enzymes including porcine-derived lipases, proteases, and amylases.

Uses: Lupase 10000 Tablet is a pancreatic enzyme supplement used to manage exocrine pancreatic insufficiency (deficient pancreatic enzyme production). It is prescribed for conditions such as:

• Cystic fibrosis
• Chronic pancreatitis
• Pancreatic cancer
• Surgical removal of the pancreas (pancreatectomy)
• It aids in the digestion of fats, carbohydrates, and proteins, thereby improving nutrient absorption and alleviating symptoms like bloating, gas, abdominal discomfort, and diarrhea caused by poor digestion. It also helps in the treatment of steatorrhea (fatty stools).

Dosage and Administration:

• Take Lupase 10000 Tablet orally with or immediately after meals or snacks, as directed by your physician.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect its effectiveness and cause mouth irritation.
• If using granules (from capsules), they can be mixed with soft foods like yogurt or applesauce, or with acidic liquids such as apple, pineapple, or orange juice, and consumed immediately without crushing.
• The dosage is individualized based on age, body weight, and the specific condition being treated, and may be required long-term.

Side Effects: Common side effects may include:

• Nausea, vomiting
• Mild stomach pain, abdominal bloating, abdominal discomfort
• Diarrhea, constipation
• Mild skin rash Serious side effects, though rare, can include fibrosing colonopathy in patients with cystic fibrosis, characterized by severe abdominal pain, swelling, constipation, and vomiting.

Precautions:

• Inform your doctor if you are allergic to Pancreatin or any porcine, cow, or buffalo products.
• Caution is advised in pregnant or breastfeeding women; consult a doctor before use.
• Patients with a history of gout, asthma, kidney problems, or liver impairment should inform their doctor.
• For diabetic patients, this medication may affect blood sugar levels, necessitating monitoring and potential adjustments to their diabetes management plan.
• Avoid concurrent use with antacids.
• Do not exceed the prescribed dose to avoid overdose symptoms like irritation or inflammation in the anal region.

Storage:

• Store Lupase 10000 Tablet in a cool and dry place away from direct sunlight.
• Keep it in its original packaging at room temperature (15-25°C or below 30°C).
• Keep out of sight and reach of children.

Frequently Asked Questions about Lupase 10000 Tablet

What is Lupase 10000 Tablet used for?

Lupase 10000 Tablet is a pancreatic enzyme supplement used to treat exocrine pancreatic insufficiency (EPI). This condition occurs when the pancreas does not produce enough digestive enzymes, which can be due to conditions like cystic fibrosis, chronic pancreatitis, pancreatic cancer, or surgical removal of the pancreas. It helps to improve digestion and relieve symptoms such as bloating, gas, abdominal discomfort, and diarrhea caused by poor digestion. It can also help manage steatorrhea (fatty stools) and aid in nutrient absorption.

How does Lupase 10000 Tablet work?

Lupase 10000 Tablet contains Pancreatin, which is a combination of digestive enzymes including lipases, proteases, and amylases. These enzymes are derived from pigs. When taken with food, these enzymes mix with the food in the gut and help break down fats, proteins, and carbohydrates into simpler forms, allowing the body to absorb nutrients more effectively.

What is the usual dosage for Lupase 10000 Tablet?

The dosage of Lupase 10000 Tablet is determined by your doctor based on your specific condition and how you respond to the medication. It should be taken during or immediately after meals or snacks with plenty of water. Do not crush or chew the tablet; swallow it whole to prevent mouth irritation.

What are the possible side effects of Lupase 10000 Tablet?

Common side effects of Lupase 10000 Tablet can include nausea, vomiting, stomach pain or discomfort, abdominal bloating, diarrhea, and mild skin rash. Most of these side effects are usually mild and resolve over time as your body adjusts to the medicine. However, if any of these symptoms persist or worsen, you should consult your doctor. In rare cases, especially with high doses in patients with cystic fibrosis, a severe bowel condition called fibrosing colonopathy (narrowing of the digestive tract) can occur, characterized by severe abdominal pain, swelling, constipation, and vomiting. Allergic reactions, though rare, can also occur, presenting as rash, wheezing, breathlessness, or swollen face/lips.

Is Lupase 10000 Tablet safe during pregnancy or breastfeeding?

Lupase 10000 Tablet should be used with caution during pregnancy. While limited human studies are available, animal studies have shown potential harmful effects on the developing baby. Your doctor will assess the benefits versus potential risks before prescribing it during pregnancy. During breastfeeding, Lupase 10000 Tablet is considered probably safe, as limited human data suggests a low risk to the baby. However, it is still advisable to consult your doctor before taking this medicine while breastfeeding.

Can Lupase 10000 Tablet be taken with other medications?

Before taking Lupase 10000 Tablet, inform your doctor about all other medicines, including supplements or herbal products you are currently taking, to avoid potential drug interactions. It's advised to avoid taking antacids one hour before or after taking pancreatin, the active ingredient in Lupase 10000 Tablet. There is also information suggesting that it might decrease the absorption of folic acid and iron.

What precautions should be taken with Lupase 10000 Tablet?

It is important to inform your doctor if you have allergies, especially to products of animal origin (this tablet contains pork-derived enzymes). Exercise caution if you have conditions like gout (as it may increase uric acid levels), asthma, kidney problems, or liver problems. Patients with cystic fibrosis should be monitored for severe abdominal pain, swelling, constipation, or vomiting, as it could indicate fibrosing colonopathy. If you have diabetes, this medicine may affect your blood sugar levels, requiring adjustments to your diabetes treatment. Do not chew or crush the tablet.

What happens if a dose is missed?

If you miss a dose of Lupase 10000 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Lupase 10000 Tablet be stored?

Lupase 10000 Tablet should be stored in a cool and dry place, away from direct sunlight, typically at room temperature (15-25°C or below 30°C). Keep it in its original packaging and out of sight and reach of children. Do not take it after the expiry date.