Syntran 100 Mg Capsule

SYNTRAN 100 MG CAPSULE

• Name: Syntran 100 MG Capsule

• Composition: Syntran 100 MG Capsule contains 100mg of Itraconazole, an antifungal agent.

• Uses: Syntran 100 MG Capsule is an antifungal medication primarily used to treat various fungal and yeast infections in different parts of the body. It is prescribed for:

  • Systemic fungal infections such as blastomycosis, histoplasmosis, and aspergillosis.
  • Superficial fungal infections including those of the mouth, throat (oral candidiasis, oropharyngeal candidiasis, esophageal candidiasis), nails (onychomycosis of toenails and fingernails), skin (tinea strains like ringworm, athlete's foot), and vagina (vaginal candidiasis/vulvovaginal candidiasis).
  • Treatment of flaky discolored patches on the chest and back (pityriasis versicolor).
  • Prevention of fungal infections in immunocompromised patients.

• Dosage and Administration: Syntran 100 MG Capsule should be taken orally as directed by a healthcare professional.

  • It is generally advised to take the capsule with food to enhance absorption.
  • Swallow the capsule whole with a glass of water; do not crush, chew, or break it.
  • Dosage and duration vary based on the type and severity of the infection and individual response.
  • For adults, typical doses may range from 100mg once or twice daily, or 200mg daily for specific conditions.
  • Do not discontinue the medication without consulting your doctor, even if symptoms improve, to prevent recurrence and resistance.

• Side Effects: Common side effects may include:

  • Headache, dizziness, fatigue, fever.
  • Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal pain, indigestion, constipation, anorexia.
  • Skin reactions: Skin rash, itching, pruritus.
  • Other: Edema (swelling), hypertension, decreased libido, hypertriglyceridemia, irregular menstrual cycle, cough, cold, throat pain, back pain, increased frequency of urine, blurred/double vision, taste changes, ringing in ears, and sensitivity of the skin to light.

  Serious side effects, though rare, can include:

  • Severe allergic reactions (skin rash, breathing difficulties, swelling of the face, lips, tongue, or neck).
  • Liver problems (yellowing of eyes or skin, dark urine, stomach pain, pale stools, loss of appetite, extreme fatigue, vomiting, or nausea), which may indicate liver failure.
  • Heart failure symptoms (shortness of breath, unexpected weight gain, swollen legs or stomach, unusual tiredness).
  • Neuropathy (tingling, numbness, weakness in limbs).
  • Severe skin disorders.

• Precautions:

  • Contraindications: Do not take Syntran 100 MG Capsule if you are allergic to itraconazole or any other components, have a history of heart failure or other serious heart conditions, or significant liver problems.
  • Pregnancy and Breastfeeding: Syntran 100 MG Capsule is a pregnancy category C drug and is generally not recommended during pregnancy, especially in the first trimester, due to potential harm to the unborn baby. It is also excreted in human milk and may harm a breastfeeding infant. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
  • Medical Conditions: Inform your doctor if you have a history of heart failure, kidney disease, liver disease, lung problems, abnormal electrolyte levels, or adrenal dysfunction. Patients with a history of heart failure should avoid this medication due to potential life-threatening adverse effects.
  • Driving and Operating Machinery: This medicine may cause dizziness, blurred/double vision, or hearing loss. Exercise caution when driving or operating machinery until you know how the medication affects you.
  • Drug Interactions: Avoid concomitant use with certain medications, including astemizole, busulfan, cisapride, terfenadine, vinca alkaloids, and fentanyl, due to increased risk of serious side effects like cardiotoxicity or severe breathing complications. Antacids or acid blockers should be avoided for at least two hours after taking Syntran as they may reduce its efficacy. Inform your doctor about all medications and herbal supplements you are taking.
  • Alcohol: Avoid alcohol consumption while taking Syntran 100 MG Capsule as it may increase the risk of liver problems and other adverse effects.
  • Monitoring: Regular monitoring of liver function tests may be required during prolonged therapy. If diabetic, test serum glucose regularly as it can cause hypoglycemia when given with sulfonylureas.

• Storage: Store Syntran 100 MG Capsule in a cool, dry place, typically between 20°C to 25°C (68°F to 77°F). Keep it in its original packaging, protected from excessive heat, moisture, and direct sunlight. Ensure it is kept out of sight and reach of children and pets.

SYNTRAN 100 MG CAPSULE is an antifungal medication manufactured by Glenmark Laboratories, containing Itraconazole as its active ingredient. It is primarily used to treat a variety of fungal and yeast infections in different parts of the body.

What is SYNTRAN 100 MG CAPSULE used for?

SYNTRAN 100 MG CAPSULE is used to treat various fungal infections, including those affecting the mouth, throat (oral thrush), vagina (vaginal candidiasis), skin (e.g., ringworm, athlete's foot, jock itch), fingernails, and toenails (onychomycosis), and internal organs like the lungs (e.g., aspergillosis, blastomycosis, histoplasmosis). It can also be prescribed to prevent fungal infections in immunocompromised patients, such as those undergoing chemotherapy.

How does SYNTRAN 100 MG CAPSULE work?

SYNTRAN 100 MG CAPSULE contains Itraconazole, which is an azole antifungal drug. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol production, it weakens and damages the fungal cell membranes, causing the leakage of essential cell contents and ultimately leading to the death of the fungus, thereby clearing the infection.

What is the usual dosage of SYNTRAN 100 MG CAPSULE?

The dosage and duration of treatment with SYNTRAN 100 MG CAPSULE depend on the type and severity of the fungal infection and your response to the medication. It is crucial to follow your doctor's instructions precisely. For adults, a common dosage for some infections can be 1 or 2 capsules, taken once or twice a day. For certain conditions like onychomycosis, a pulse-dosing regimen might be prescribed. It's often recommended to take the capsules with or immediately after food for optimal absorption.

What are the possible side effects of SYNTRAN 100 MG CAPSULE?

Common side effects of SYNTRAN 100 MG CAPSULE can include nausea, headache, dizziness, fatigue, diarrhea, stomach pain, gas or bloating, and menstrual problems. More serious, but rare, side effects can include liver toxicity, heart failure, severe allergic reactions, peripheral neuropathy (tingling/numbness), and blurred vision or hearing loss. If you experience severe or persistent side effects, or any signs of liver problems (e.g., yellowing of skin/eyes, dark urine, severe fatigue), seek immediate medical attention.

Is SYNTRAN 100 MG CAPSULE safe during pregnancy or breastfeeding?

SYNTRAN 100 MG CAPSULE is generally not recommended during pregnancy, especially in the first trimester, as it may pose harmful effects to the fetus. Women of childbearing age should use effective contraception during treatment and continue for a period after stopping the medication. It is also generally considered unsafe during breastfeeding as it may excrete into breast milk. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can SYNTRAN 100 MG CAPSULE be taken with other medications?

SYNTRAN 100 MG CAPSULE (Itraconazole) can interact with many other medications, potentially increasing their levels and the risk of side effects. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking. Specific interactions include certain medications for allergies, cholesterol-lowering drugs, medicines for irregular heartbeats, some anti-cancer medicines, anticoagulants like warfarin, anti-HIV medicines, and medications for erectile dysfunction. Concomitant use with certain drugs like alfuzosin, dofetilide, astemizole, and cisapride is generally contraindicated due to increased risk of serious side effects like heart rhythm problems. Antacids or other medications that affect stomach acid should generally be avoided within 2 hours before or after taking Itraconazole capsules as they can reduce its absorption.

What precautions should be taken with SYNTRAN 100 MG CAPSULE?

Before taking SYNTRAN 100 MG CAPSULE, inform your doctor if you have a history of heart failure, liver disease, kidney disease, lung disorders, or a weakened immune system. Regular monitoring of liver function may be advised during prolonged treatment. Since it can cause dizziness or blurred vision, avoid driving or operating heavy machinery until you know how the medicine affects you. Alcohol consumption should generally be avoided during treatment.

What happens if a dose of SYNTRAN 100 MG CAPSULE is missed?

If you miss a dose of SYNTRAN 100 MG CAPSULE, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important to complete the full course of medication as prescribed, even if your symptoms improve, to prevent the infection from returning or developing drug resistance.

How should SYNTRAN 100 MG CAPSULE be stored?

SYNTRAN 100 MG CAPSULE should be stored in a cool, dry place, typically below 30°C (86°F) or 25°C (77°F), and in its original packaging. Keep the medicine out of the reach of children and pets.