Tenvir Af 25 Mg Tablet (30 Tab)

TENVIR AF 25 MG TABLET

TENVIR AF 25 MG TABLET is an antiviral medication manufactured by Cipla Ltd.

• Name:

  • Brand Name: TENVIR AF 25 MG TABLET
  • Common Name: Tenofovir Alafenamide

• Composition:

  • Each tablet contains 25 mg of Tenofovir Alafenamide.

• Uses: TENVIR AF 25 MG TABLET is primarily used to treat:

  • Chronic Hepatitis B virus (HBV) infection in adults with compensated liver disease. It is also indicated for adolescents aged 12 years and older with chronic HBV.
  • Human Immunodeficiency Virus type 1 (HIV-1) infection in adults, typically as part of combination therapy with other antiretroviral medicines.

• Dosage and Administration:

  • The typical dosage for chronic hepatitis B is 25 mg once daily, or as advised by a doctor.
  • It should be taken with food to enhance absorption.
  • Swallow the tablet whole with a glass of water; do not break, chew, or crush it.
  • It is important not to miss doses and to complete the full course of treatment as prescribed by your doctor.

• Side Effects: Common side effects may include:

  • Headache
  • Diarrhoea
  • Nausea
  • Vomiting
  • Rash
  • Fatigue
  • Abdominal pain
  • Cough
  • Back pain
  • Joint pain
  • Indigestion
  • Dizziness

  Serious side effects can include lactic acidosis (buildup of lactic acid in the blood) and hepatomegaly (enlarged liver). Rarely, skin reactions or liver damage may occur.

• Precautions:

  • Allergy: Avoid if allergic to Tenofovir Alafenamide or any other components of the tablet.
  • Kidney and Liver Impairment: Use with caution in patients with kidney or liver problems. It is not recommended for severe kidney or liver impairment.
  • Pregnancy and Breastfeeding: Consult a doctor if pregnant, planning pregnancy, or breastfeeding. Generally considered safe during pregnancy and probably safe during breastfeeding if prescribed.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of side effects like liver damage and dizziness.
  • Driving and Machinery: This medicine may cause dizziness or sleepiness; avoid driving or operating heavy machinery if you experience these effects.
  • Pediatric Use: Not recommended for children less than 12 years of age for HBV and for children weighing less than 25 kg for HIV-1 infection. Some sources state not for children below 18 years of age for HIV.
  • Infection Transmission: Patients should take necessary precautions to avoid infecting others with HBV or HIV.
  • Monitoring: Regular blood tests are needed to monitor liver function, HBV/HIV viral load, and blood counts during treatment and for a period after stopping the medicine.
  • Other Medications: Inform your doctor about all medicines, supplements, or herbal products you are taking to avoid potential interactions.

• Storage:

  • Store at a temperature between 20°C to 25°C (68°F to 77°F) or below 30°C.
  • Keep away from moisture, heat, and light.
  • Do not freeze.
  • Keep it in its original packaging.
  • Keep out of reach and sight of children and pets.

Here are frequently asked questions about TENVIR AF 25 MG TABLET:

What is TENVIR AF 25 MG TABLET used for?

TENVIR AF 25 MG TABLET, which contains Tenofovir Alafenamide (TAF), is primarily used to treat chronic (long-term) Hepatitis B virus (HBV) infection in adults with compensated liver disease. It is also used in combination with other antiretroviral medications for the treatment of Human Immunodeficiency Virus type 1 (HIV-1) infection.

How does TENVIR AF 25 MG TABLET work?

TENVIR AF 25 MG TABLET is a prodrug of tenofovir, meaning it's converted into its active form in the body. It belongs to a class of medications called nucleotide reverse transcriptase inhibitors (NRTIs). Once it enters liver cells, it is converted into tenofovir diphosphate, which then inhibits the HBV reverse transcriptase and HIV-1 reverse transcriptase enzymes. This action prevents the virus from multiplying, thereby reducing the viral load and helping to clear the infection.

What is the usual dosage for TENVIR AF 25 MG TABLET?

For chronic hepatitis B infection, the usual dosage for adults and children 6 years of age and older weighing at least 25 kilograms (kg) is one 25 mg tablet taken orally once daily with food.

What are the possible side effects of TENVIR AF 25 MG TABLET?

Common side effects may include headache, abdominal pain, nausea, diarrhea, vomiting, gas (flatulence), cough, fatigue, back pain, and rash. More serious, but rare, side effects can include lactic acidosis (too much acid in the blood), severe liver problems, and kidney problems. You should contact your doctor immediately if you experience severe symptoms like unusual tiredness, yellowing of the skin or eyes, dark urine, severe stomach pain, or decreased urination.

Is TENVIR AF 25 MG TABLET safe during pregnancy or breastfeeding?

Pregnancy: Limited data on tenofovir alafenamide (TAF) in pregnancy, particularly for HIV-infected women, suggest high efficacy and a low risk of adverse effects. However, TAF is not universally recommended during pregnancy due to ongoing data collection. Close fetal monitoring is advised. Breastfeeding: Studies have shown that tenofovir alafenamide and its active metabolite, tenofovir, are present in breastmilk in low concentrations, resulting in negligible infant exposure, which supports its use to prevent mother-to-child transmission in breastfeeding women with chronic hepatitis B. However, for HIV, HIV-infected mothers are generally advised not to breastfeed to avoid postnatal transmission of HIV. It is important to discuss the risks and benefits with your healthcare provider.

Can TENVIR AF 25 MG TABLET be taken with other medications?

TENVIR AF 25 MG TABLET can interact with several medications. It is not recommended to take it with strong inducers of P-glycoprotein (P-gp), such as certain anticonvulsants (e.g., carbamazepine, phenobarbital, phenytoin), antimycobacterials (e.g., rifampicin, rifabutin), or the herbal product St. John's wort, as these can decrease the effectiveness of TAF. Co-administration with drugs that inhibit P-gp and BCRP may increase TAF concentrations. Additionally, it should not be taken with other medicines containing tenofovir alafenamide, tenofovir disoproxil, or adefovir dipivoxil. High doses of nonsteroidal anti-inflammatory drugs (NSAIDs) should be avoided due to an increased risk of kidney damage. Always inform your doctor or pharmacist about all prescription, over-the-counter, herbal products, and vitamin supplements you are taking.

What precautions should be taken while taking TENVIR AF 25 MG TABLET?

It is very important not to stop taking TENVIR AF 25 MG TABLET without consulting your doctor, as discontinuing treatment can lead to a severe worsening (acute exacerbation) of your hepatitis B infection. Regular blood and urine tests will be needed to monitor your liver and kidney function during treatment. If you are co-infected with HIV, TENVIR AF should not be used as a single agent for HIV treatment because it can lead to the development of HIV resistance. Your doctor may test you for HIV before you begin treatment for HBV. The medication should be taken with food. Use with caution if you have existing kidney problems, and it is generally not recommended for severe hepatic impairment.

What happens if a dose of TENVIR AF 25 MG TABLET is missed?

If you miss a dose of TENVIR AF 25 MG TABLET and less than 18 hours have passed since your usual time, take it as soon as you remember. If more than 18 hours have passed, skip the missed dose and take your next dose at your regularly scheduled time. Do not take a double dose to make up for a missed one.

How should TENVIR AF 25 MG TABLET be stored?

TENVIR AF 25 MG TABLET should be stored below 30°C (86°F). Keep the tablets in their original container, tightly closed, to protect them from moisture. Keep this medicine out of the reach of children.