Zoryl Mf 1 Mg Tablet

ZORYL MF 1 MG TABLET

Zoryl MF 1 mg Tablet is an anti-diabetic medication manufactured by Intas Pharmaceuticals Ltd., used to manage type 2 diabetes mellitus in adults. It is a combination therapy, particularly beneficial when blood sugar levels are not adequately controlled by diet, exercise, or single-agent therapies.

Composition

Each film-coated tablet contains:

• Glimepiride: 1 mg
• Metformin Hydrochloride: 850 mg

Uses

Zoryl MF 1 mg Tablet is primarily used for the treatment of type 2 diabetes mellitus in adults. It aids in controlling high blood sugar levels, thereby reducing the risk of associated serious complications such as kidney damage, eye damage, nerve problems, and loss of limbs. The medicine works by increasing insulin production in the pancreas (Glimepiride) and by reducing glucose production in the liver, delaying glucose absorption from the intestines, and improving the body's sensitivity to insulin (Metformin).

Dosage and Administration

Zoryl MF 1 mg Tablet should be taken in the dose and duration as advised by a healthcare professional. It is recommended to take the tablet whole with food, consistently at the same time each day, without chewing, crushing, or breaking it. Continuous use as prescribed is important, even if blood sugar levels appear stable, to avoid potential complications.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood sugar levels), with symptoms like sweating, dizziness, headache, and shaking.
• Nausea
• Diarrhea
• Stomach pain or discomfort
• Vomiting
• Taste disturbance (metallic taste)
• Headache
• Loss of appetite
• Skin rashes
• Weight gain
• Upper respiratory tract infections

Serious Side Effects (Rare):

• Lactic acidosis (a medical emergency caused by increased lactic acid in the blood), symptoms include muscle pain or weakness, dizziness, severe tiredness, difficulty breathing, stomach pain, nausea, vomiting, and slow heart rate.
• Liver inflammation (jaundice, yellowing of skin or eyes).
• Severe allergic reactions (skin rash, hives, increased sensitivity to sun, inflammation of blood vessels).
• Vitamin B12 deficiency (with long-term use).

Precautions

• Hypoglycemia Management: Patients should be vigilant for symptoms of low blood sugar and carry a quick source of glucose.
• Alcohol Consumption: Avoid excessive alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Contraindications: Not recommended for individuals with type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver disease, dehydration, severe infections, shock, or a history of heart problems.
• Pregnancy and Breastfeeding: Not recommended during pregnancy as it may harm the unborn baby. Avoid breastfeeding as the medicine may pass into breast milk and cause adverse effects in the baby.
• Drug Interactions: Inform your doctor about all other medications being taken, as interactions can occur (e.g., with other antidiabetic medicines, corticosteroids, thiazide diuretics, calcium channel blockers).
• Monitoring: Regular monitoring of blood sugar levels and additional tests (like fasting blood glucose, postprandial blood glucose, and glycosylated hemoglobin) are crucial.
• Driving/Operating Machinery: Exercise caution as the medicine may decrease alertness.

Storage

Store the medicine in a cool and dry place, away from heat, moisture, and direct sunlight. Keep it out of reach and sight of children. The recommended storage temperature is below 30°C, or between 10°C to 25°C. Do not keep outdated medicine.

ZORYL MF 1 MG Tablet is a combination medicine containing Glimepiride and Metformin, primarily used to treat type 2 diabetes mellitus in adults.

Here are some frequently asked questions about ZORYL MF 1 MG Tablet:

What is ZORYL MF 1 MG Tablet used for?

ZORYL MF 1 MG Tablet is prescribed for the management of type 2 diabetes mellitus in adults. It helps to control high blood sugar levels, particularly when diet and exercise alone, or treatment with either glimepiride or metformin individually, are not sufficient. By regulating blood glucose, it helps reduce the risk of long-term diabetes complications such as kidney damage, eye problems, nerve issues, and cardiovascular diseases.

How does ZORYL MF 1 MG Tablet work?

ZORYL MF 1 MG Tablet combines two anti-diabetic medications: Glimepiride and Metformin.

• Glimepiride is a sulfonylurea that stimulates the beta cells in the pancreas to produce and release more insulin, which helps lower blood glucose levels.
• Metformin is a biguanide that works by reducing the amount of glucose produced by the liver, delaying the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin, allowing cells to use blood sugar more effectively. Together, they provide a dual-action approach to improve glycemic control.

What is the usual dosage for ZORYL MF 1 MG Tablet?

The dosage of ZORYL MF 1 MG Tablet is determined by your doctor based on your individual blood glucose levels and response to treatment. It should be taken regularly, usually once a day, with food, at the same time each day to achieve the most benefit. Do not chew, crush, or break the tablet, and do not exceed the prescribed dose.

What are the possible side effects of ZORYL MF 1 MG Tablet?

Common side effects include hypoglycemia (low blood sugar), altered taste, nausea, stomach pain, diarrhea, and headache. More serious, though rare, side effects can include lactic acidosis (an accumulation of lactic acid in the blood), which is a medical emergency, and a long-term use may lead to vitamin B12 deficiency. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, difficulty breathing, nausea, vomiting, stomach pain, or a slow heart rate. If you experience any persistent or worsening side effects, consult your doctor.

Is ZORYL MF 1 MG Tablet safe during pregnancy or breastfeeding?

ZORYL MF 1 MG Tablet is generally considered unsafe during pregnancy and breastfeeding. It may harm the unborn baby or pass into breast milk and cause adverse effects in the infant. Pregnant or breastfeeding women, or those planning to become pregnant, should consult their doctor for alternative treatment options.

Can ZORYL MF 1 MG Tablet be taken with other medications?

ZORYL MF 1 MG Tablet can interact with various medications. Taking it with other antidiabetic medicines (like insulin or gliclazide) can increase the risk of low blood sugar. Corticosteroids and thiazide diuretics may reduce its effectiveness. Certain medications like amlodipine and nifedipine can increase the risk of lactic acidosis. It's crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid potential interactions. Alcohol consumption should be avoided as it can increase the risk of hypoglycemia and lactic acidosis.

What precautions should be taken?

Several precautions should be observed when taking ZORYL MF 1 MG Tablet:

• Alcohol: Avoid alcohol as it can increase the risk of low blood sugar and lactic acidosis.
• Kidney and Liver Disease: Use with caution in patients with kidney or liver disease. It is not recommended for those with severe kidney or liver disease.
• Type 1 Diabetes: This medicine is not for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.
• Hypoglycemia: Be aware of the symptoms of low blood sugar (sweating, dizziness, headache, shaking) and know how to manage them, often by consuming a fast-acting source of glucose. Regular monitoring of blood sugar levels is important.
• Surgery: Inform your doctor about your medication if you are scheduled for surgery under general anesthetic.

What happens if a dose is missed?

If you miss a dose of ZORYL MF 1 MG Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should it be stored?

ZORYL MF 1 MG Tablet should be stored in a cool, dry place, away from direct sunlight and moisture, at temperatures not exceeding 30°C. Keep it out of reach and sight of children.