Sgltd Trio 1000mg Tab

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• Name: SGLTD-TRIO 1000 Tablet (common name), manufactured by Mankind Pharma Ltd.
• Composition: Dapagliflozin (10mg), Metformin (1000mg), Sitagliptin (100mg).
• Uses: Management of Type 2 Diabetes Mellitus in adults, adjunct to diet and exercise. Improves blood sugar control, enhances insulin sensitivity, promotes glucose excretion, reduces hepatic glucose production. Also noted for cardiovascular and kidney protection and supporting weight loss.
• Dosage and Administration: Take as advised by a doctor. Can be taken with or without food, but taking it with meals may reduce gastrointestinal discomfort. Should be taken at the same time every day. Do not crush, break, or chew. Do not stop without consulting a doctor.
• Side Effects:
  • Common: Hypoglycemia (low blood glucose), nausea, vomiting, diarrhea, abdominal pain/stomach upset, headache, flatulence, genital infections (especially female mycotic infections), urinary tract infections, nasopharyngitis (sore throat, nasal congestion), increased/frequent urination, drowsiness, dizziness, constipation, itching, dry mouth, decreased weight, thirst.
  • Serious (rare, require immediate medical attention): Lactic acidosis (weakness, breathing difficulty, severe stomach pain, unexplained weight loss, muscular cramps, rapid breathing, feeling cold), ketoacidosis (nausea, vomiting, confusion, fruity breath), acute pancreatitis (severe and persistent abdominal pain radiating to the back with/without nausea/vomiting), severe allergic reactions (rash, hives, blisters, swelling of face/lips/tongue/throat, difficulty breathing/swallowing), bullous pemphigoid (blistering of the skin).
• Precautions:
  • Not for Type 1 Diabetes or diabetic ketoacidosis.
  • Avoid if allergic to any components.
  • Not recommended for children under 18.
  • Pregnancy/Breastfeeding: Consult doctor; generally not recommended unless benefits outweigh risks.
  • Liver/Kidney Disease: Not recommended for severe liver/kidney disease; use with caution and close monitoring in mild to moderate cases due to increased risk of lactic acidosis.
  • Alcohol: Limit consumption due to increased risk of hypoglycemia and lactic acidosis.
  • Elderly: Use with caution and close monitoring of renal function and blood sugar levels.
  • Drug Interactions: Interacts with insulin, other antidiabetic agents, diuretics (thiazide and loop diuretics), carbonic anhydrase inhibitors, NSAIDs, COX-2 inhibitors, ACE inhibitors, angiotensin II receptor antagonists, sympathomimetics, iodinated contrast agents, alcohol-containing medicines, cimetidine, ranolazine, dolutegravir, vandetanib, digoxin. Inform doctor about all medications, herbs, and supplements.
  • May cause dizziness or drowsiness; avoid driving/operating machinery if affected.
• Storage: Store in a cool, dry place away from direct sunlight and out of reach of children. Store below 30°C.SGLTD-TRIO 1000 Tablet

Name: SGLTD-TRIO 1000 Tablet Brand Name: SGLTD-TRIO 1000 (Manufactured by Mankind Pharma Ltd.)

Composition: Each tablet contains a fixed-dose combination of:

• Dapagliflozin: 10 mg
• Metformin: 1000 mg
• Sitagliptin: 100 mg

Uses: SGLTD-TRIO 1000 Tablet is an antidiabetic medicine prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used as an adjunct to diet and exercise when blood sugar levels are not adequately controlled by metformin alone or dual therapy. This medication helps to:

• Improve overall blood sugar control by reducing glucose production in the liver, delaying sugar absorption from the intestines, increasing insulin release, enhancing insulin sensitivity, and promoting glucose excretion through urine.
• Offer cardiovascular and kidney protection.
• Support weight and metabolic control.

Dosage and Administration: Take SGLTD-TRIO 1000 Tablet exactly as advised by your doctor. It can be taken with or without food, though taking it with meals may help reduce gastrointestinal discomfort. It is recommended to take the medicine at the same time every day for optimal benefits. Do not crush, break, or chew the tablet. Do not stop taking this medicine without consulting your doctor, as this may lead to increased blood sugar levels and a higher risk of complications.

Side Effects:

• Common Side Effects: Hypoglycemia (low blood glucose), nausea, vomiting, diarrhea, abdominal pain, headache, flatulence, female genital mycotic infections, urinary tract infections, nasopharyngitis (sore throat, nasal congestion), increased or frequent urination, drowsiness, dizziness, constipation, itching, dry mouth, decreased weight, and thirst.
• Serious Side Effects (Seek immediate medical attention if experienced): Symptoms of lactic acidosis (weakness, breathing difficulty, severe stomach pain, unexplained weight loss, muscular cramps, rapid breathing, feeling cold), ketoacidosis (nausea, vomiting, confusion, fruity breath), acute pancreatitis (severe and persistent abdominal pain that may radiate to the back with or without nausea and vomiting), severe allergic reactions (rash, hives, blisters, swelling of the face, lips, tongue, and throat causing difficulty breathing or swallowing), or bullous pemphigoid (blistering of the skin).

Precautions:

• SGLTD-TRIO 1000 Tablet is not for the treatment of Type 1 Diabetes Mellitus or diabetic ketoacidosis.
• Do not take this medicine if you are allergic to dapagliflozin, metformin, sitagliptin, or any other components of the tablet.
• Pregnancy and Breastfeeding: Generally not recommended. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Kidney and Liver Conditions: Not recommended for patients with severe liver or kidney disease. Use with caution in patients with mild to moderate kidney disease, requiring close monitoring due to an increased risk of lactic acidosis.
• Alcohol Consumption: Limit alcohol intake while on this medication as it can increase the risk of hypoglycemia and lactic acidosis.
• Elderly Patients: Use with caution, and close monitoring of renal function and blood sugar levels is recommended.
• Drug Interactions: Inform your doctor about all medications, including herbal supplements, you are currently taking, as SGLTD-TRIO 1000 can interact with certain drugs such as insulin, other antidiabetic agents, diuretics, NSAIDs, certain blood pressure medications (ACE inhibitors, ARBs), and iodinated contrast agents.
• If you experience dizziness or drowsiness, avoid driving or operating machinery.
• Not recommended for use in children below 18 years of age.

Storage: Store SGLTD-TRIO 1000 Tablet in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. Ensure it is stored below 30°C. Do not use the medicine past its expiration date.

SGLTD TRIO 1000MG Tablet is a combination medication manufactured by Mankind Pharma Ltd., used for the management of Type 2 Diabetes Mellitus. It contains three active ingredients: Dapagliflozin (10 mg), Metformin (1000 mg), and Sitagliptin (100 mg).

Here are some frequently asked questions about SGLTD TRIO 1000MG Tablet:

What is SGLTD TRIO 1000MG Tablet used for?

SGLTD TRIO 1000MG Tablet is used to improve blood sugar control in adults with Type 2 Diabetes Mellitus, especially when diet, exercise, and therapy with conventional medicines alone do not provide adequate control. It is also beneficial for patients requiring enhanced blood sugar management beyond dual therapy. This medicine helps manage blood glucose levels and can assist in preventing diabetes-related complications such as kidney damage, eye problems, and nerve issues. Additionally, it may help lower the risk of heart failure and diabetic kidney disease.

How does SGLTD TRIO 1000MG Tablet work?

SGLTD TRIO 1000MG Tablet combines three different antidiabetic medicines that work through complementary mechanisms:

• Dapagliflozin (10 mg): This is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by removing excess glucose from the body through the urine, independent of insulin levels, thereby lowering blood sugar.
• Metformin (1000 mg): A biguanide, Metformin reduces the amount of glucose produced by the liver and delays glucose absorption from the intestines. It also improves the body's sensitivity to insulin, allowing cells to better utilize glucose.
• Sitagliptin (100 mg): This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of certain natural substances (incretin hormones) that help the pancreas release more insulin and signal the liver to stop producing sugar when blood sugar levels are high.

What is the usual dosage of SGLTD TRIO 1000MG Tablet?

The dosage and frequency of SGLTD TRIO 1000MG Tablet are determined by your doctor based on your individual health condition and response to treatment. It is usually taken orally, with or without food, but it is recommended to take it consistently at the same time each day to reduce the risk of gastrointestinal side effects. It's important not to crush, break, or chew the tablet, and not to alter the prescribed dose or discontinue the medication without consulting your doctor.

What are the possible side effects of SGLTD TRIO 1000MG Tablet?

Common side effects may include:

• Urinary tract infections (UTIs)
• Female genital mycotic (fungal) infections
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Diarrhea
• Headache
• Nausea and vomiting
• Abdominal pain
• Hypoglycemia (low blood sugar), especially when taken with other antidiabetic medicines or alcohol
• Increased or more frequent urination
• Flatulence

Serious but rare side effects requiring immediate medical attention include signs of lactic acidosis (weakness, breathing difficulty, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), acute pancreatitis (severe and persistent abdominal pain), or severe allergic reactions (rash, swelling, difficulty breathing).

Is SGLTD TRIO 1000MG Tablet safe during pregnancy or breastfeeding?

SGLTD TRIO 1000MG Tablet is generally not recommended during pregnancy as there is limited information on its effects in pregnant women. It should only be used if the potential benefits justify the potential risks to the fetus, and a doctor should be consulted if you are pregnant or planning to conceive. Similarly, it is not recommended during breastfeeding, as some components may pass into breast milk. Always consult your doctor if you are pregnant or breastfeeding before taking this medicine.

Can SGLTD TRIO 1000MG Tablet be taken with other medications?

SGLTD TRIO 1000MG Tablet can interact with various medications. It is crucial to inform your doctor about all prescription, non-prescription, herbal supplements, and other medicines you are taking. Particular care should be taken with:

• Other antidiabetic agents: Such as insulin or sulfonylureas, as co-administration may increase the risk of extremely low blood sugar (hypoglycemia).
• Diuretics (water pills): Medicines like furosemide or hydrochlorothiazide may increase the risk of dehydration, low blood pressure, and lactic acidosis.
• Carbonic Anhydrase Inhibitors: Such as acetazolamide, which can increase the risk of lactic acidosis.
• Certain antibiotics (e.g., clarithromycin), antifungals (e.g., ketoconazole, itraconazole), and HIV/AIDS medicines (e.g., ritonavir): These can impact kidney function and drug metabolism.
• Corticosteroids: Used for pain and inflammatory conditions.
• NSAIDs and COX-2 inhibitors: Medicines used for pain and inflammation.
• Cimetidine: A gastric medicine.

What precautions should be taken?

• Kidney and Liver Disease: SGLTD TRIO 1000MG Tablet is not recommended for patients with severe kidney or liver disease due to potential risks, including lactic acidosis from metformin accumulation. Close monitoring is essential in those with less severe impairment.
• Alcohol Consumption: Avoid or limit alcohol consumption while taking this medication, as it can increase the risk of hypoglycemia and lactic acidosis.
• Driving and Operating Machinery: The medicine usually does not affect the ability to drive, but if you experience dizziness or drowsiness, avoid these activities until you are certain you can do so safely.
• Dehydration: Drink plenty of fluids to prevent dehydration, especially due to dapagliflozin's action of removing sugar via urine.
• Type 1 Diabetes and Diabetic Ketoacidosis: This medicine is not meant for managing Type 1 Diabetes or diabetic ketoacidosis.
• Children: SGLTD TRIO 1000MG Tablet is not recommended for use in children below 18 years of age.

What happens if a dose is missed?

If you miss a dose of SGLTD TRIO 1000MG Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this might cause your blood sugar level to fall rapidly.

How should it be stored?

SGLTD TRIO 1000MG Tablet should be stored in a cool and dry place, away from direct sunlight. Keep the medication out of the sight and reach of children. Do not use the medicine past its expiration date. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.