Consivas Ez 20 Mg Tablet (10 Tab)

CONSIVAS EZ 20 MG TABLET

CONSIVAS EZ 20 MG TABLET, manufactured by Emcure Pharmaceuticals Ltd., is a combination medication used to manage high cholesterol and reduce the risk of cardiovascular events.

Composition

Each tablet contains:

• Rosuvastatin: 20 mg
• Ezetimibe: 10 mg

Uses

CONSIVAS EZ 20 MG TABLET is primarily prescribed for:

• Treating high cholesterol levels (hyperlipidemia, hypercholesterolemia, dyslipidemia), including primary hyperlipidaemia and mixed dyslipidaemia.
• Reducing LDL ("bad") cholesterol and triglycerides, while increasing HDL ("good") cholesterol.
• Preventing heart attacks, strokes, and other cardiovascular diseases.
• Managing lipid levels in patients with familial hypercholesterolemia.

Dosage and Administration

This medicine should be taken orally as directed by a doctor. It is typically taken once daily, with or without food, at the same time each day to maintain consistent blood levels. The tablet should be swallowed whole with water and not crushed, chewed, or broken. Do not stop taking the medication prematurely, even if symptoms improve.

Side Effects

Common Side Effects include:

• Headache, dizziness
• Nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence
• Muscle pain (myalgia), joint pain, back pain, weakness (asthenia), fatigue
• Upper respiratory tract infection, common cold

Serious Side Effects (seek immediate medical attention):

• Unexplained muscle pain or weakness with fever or reddish-brown urine (rhabdomyolysis)
• Liver problems (yellowing of skin or eyes, dark urine, severe abdominal pain, persistent nausea, vomiting, loss of appetite)
• Severe allergic reactions (skin rash, itching, swelling of face or throat)

Precautions

• Contraindications: Do not use if allergic to ezetimibe, rosuvastatin, or any other ingredients. It is contraindicated in active liver disease, severe kidney problems, muscle disorders, pregnancy, and breastfeeding.
• Medical Conditions: Inform your doctor if you have liver or kidney problems, diabetes, severe lung disease, thyroid disorders, or a history of musculoskeletal disorders.
• Alcohol: Avoid excessive alcohol consumption as it may increase the risk of liver damage.
• Monitoring: Regular monitoring of liver function and blood sugar levels may be recommended during treatment.
• Interactions: Inform your doctor about all other medications, especially immunosuppressants (like ciclosporin), fibrates (like gemfibrozil), blood thinners (like warfarin), and antacids, as they may interact with Consivas EZ 20 Tablet.

Storage

Store in a cool and dry place, protected from moisture, sunlight, and heat, ideally between 20-25°C or below 30°C. Keep out of sight and reach of children and pets.

CONSIVAS EZ 20 MG TABLET: Frequently Asked Questions

What is Consivas EZ 20 MG Tablet used for?

Consivas EZ 20 MG Tablet is a combination medicine primarily used to treat high cholesterol levels in the blood, a condition known as hyperlipidemia or dyslipidemia. It helps to lower "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL). By managing cholesterol levels, it also significantly reduces the risk of cardiovascular events such as heart attacks and strokes. It can be particularly beneficial for individuals who have not achieved their target LDL cholesterol levels with statin therapy alone, including those with homozygous familial hypercholesterolemia (HoFH).

How does Consivas EZ 20 MG Tablet work?

Consivas EZ 20 MG Tablet works through the combined action of its two active ingredients: rosuvastatin and ezetimibe. Rosuvastatin is a statin that reduces the production of cholesterol in the liver by inhibiting the HMG-CoA reductase enzyme, which is crucial for cholesterol synthesis. Ezetimibe complements this by decreasing the absorption of cholesterol from the diet in the small intestine, specifically by blocking the Niemann-Pick C1-Like 1 (NPC1L1) protein. Together, these mechanisms provide a comprehensive approach to lowering blood cholesterol levels.

What is the usual dosage for Consivas EZ 20 MG Tablet?

The typical starting dose for Consivas EZ 20 MG Tablet is 20mg, taken once daily. It should be swallowed whole with a glass of water, and can be taken with or without food. To achieve optimal results and maintain consistent drug levels in your body, it is best to take the tablet at the same time each day. Your physician may adjust the dosage based on your individual response, the condition being treated, and other factors such as kidney function. It is crucial to strictly adhere to your doctor's instructions and not to stop the medication prematurely.

What are the possible side effects of Consivas EZ 20 MG Tablet?

Common side effects of Consivas EZ 20 MG Tablet may include headache, muscle pain (myalgia), weakness (asthenia), back pain, stomach pain, nausea, diarrhea, constipation, and dizziness. These are usually mild and temporary. However, more serious side effects, though rare, can occur. You should seek immediate medical attention if you experience unexplained muscle pain or weakness accompanied by fever or dark reddish-brown urine (signs of rhabdomyolysis), severe allergic reactions (skin rashes, itching, swelling of face or throat), or symptoms of liver problems (fatigue, abdominal pain, yellowing of skin or eyes, dark urine, loss of appetite, vomiting).

Is Consivas EZ 20 MG Tablet safe during pregnancy or breastfeeding?

No, Consivas EZ 20 MG Tablet is considered highly unsafe and is not recommended for use during pregnancy. Rosuvastatin, one of its active ingredients, may cause significant harm to a developing baby. Women of childbearing age should use effective contraception while taking this medicine. It is also not recommended during breastfeeding, as limited human data suggests the drug may pass into breast milk and potentially harm the baby. Always consult your doctor for alternative treatment options if you are pregnant, planning to become pregnant, or breastfeeding.

Can Consivas EZ 20 MG Tablet be taken with other medications?

Consivas EZ 20 MG Tablet can interact with several other medications, affecting their effectiveness or increasing the risk of side effects. It is essential to inform your doctor about all medicines, supplements, or herbal products you are currently taking. Notable interactions include:

• Immunosuppressants (e.g., ciclosporin): Can increase the concentration of rosuvastatin and ezetimibe in your blood.
• Fibrates (e.g., gemfibrozil, fenofibrate): Can increase the effect of rosuvastatin and raise the risk of muscle damage.
• Blood thinners (anticoagulants like warfarin): May alter their effects, requiring careful monitoring.
• Antacids (containing aluminium and magnesium hydroxide): Can reduce the absorption of rosuvastatin; maintain a 2-hour gap between doses.
• Anti-HIV medications (e.g., ritonavir, lopinavir, atazanavir): Can increase blood levels of rosuvastatin and the risk of liver damage and rhabdomyolysis.
• Grapefruit juice: Avoid consuming large amounts as it can increase the concentration of rosuvastatin in your bloodstream, potentially increasing side effects.

What precautions should be taken while taking Consivas EZ 20 MG Tablet?

Several precautions should be taken:

• Liver and Kidney Conditions: Inform your doctor if you have any pre-existing liver or kidney problems, as dose adjustments may be needed, and the medicine is not recommended for severe cases. Regular monitoring of liver function tests is often recommended.
• Muscle Problems: Be cautious if you have a history of muscle disorders or experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever.
• Diabetes: Regular monitoring of blood sugar levels may be recommended as statins can slightly increase blood glucose.
• Alcohol Consumption: Avoid excessive alcohol intake as it can increase the risk of liver damage.
• Elderly Patients: Elderly patients may be more susceptible to side effects, requiring close monitoring and potential dosage adjustments.
• Driving: This medicine may cause dizziness, so caution is advised while driving or operating machinery.
• Lifestyle Modifications: For optimal results, it is advisable to combine the medication with a healthy low-fat diet, regular exercise, smoking cessation, and stress management.

What happens if a dose of Consivas EZ 20 MG Tablet is missed?

If you miss a dose of Consivas EZ 20 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Consivas EZ 20 MG Tablet be stored?

Consivas EZ 20 MG Tablet should be stored at room temperature (20-25°C or below 30°C) in a clean and dry place. Protect it from moisture, direct sunlight, and heat. Keep the medicine out of reach of children and pets. Always check the expiration date before use.