NEPTAZ 200 MG TABLET is a medication primarily prescribed for the management of chronic heart failure. It is manufactured by Mankind Pharma Ltd.

Name

• Brand Name: NEPTAZ 200 MG TABLET

Composition

NEPTAZ 200 MG TABLET is a combination of two active ingredients:

• Sacubitril (97 mg)
• Valsartan (103 mg) This combination belongs to a class of medicines known as Angiotensin Receptor Neprilysin Inhibitors (ARNI).

Uses

NEPTAZ 200 MG TABLET is used to treat:

• Heart Failure: It is indicated for adults with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction. It helps reduce the risk of cardiovascular death and hospitalization in these patients. It can also be used in children above one year of age for heart failure. The medication works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body and helping the body retain less water.

Dosage and Administration

• NEPTAZ 200 MG TABLET should be taken exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• It can be taken with or without food.
• For maximum benefits, it is recommended to take the medicine at a consistent time each day.
• Do not stop taking the medication abruptly, even if you feel well, as this may worsen your condition.

Side Effects

Common Side Effects

• Dizziness, light-headedness (low blood pressure/hypotension)
• Cough
• Nausea
• Diarrhoea
• Weakness, fatigue, tiredness
• Headache
• Signs of high potassium levels in the blood (e.g., irregular heartbeat, muscle weakness)
• Decrease in renal (kidney) function
• Signs of low red blood cells (anemia)
• Fainting or spinning sensation
• Inflammation of the lining of the stomach (stomach pain, nausea)
• Signs of low sugar levels in the blood (e.g., fast heartbeat, sweating, nervousness or anxiety)

Serious Side Effects (seek immediate medical attention if experienced)

• Severe allergic reactions, including angioedema (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing).

Precautions

• Allergies: Do not take NEPTAZ 200 MG TABLET if you are allergic to Sacubitril, Valsartan, or any other ingredients in the medicine.
• Pregnancy and Breastfeeding: This medicine is not recommended during pregnancy (especially after the first 3 months) due to potential harm to the baby. It is also not advised for use in breastfeeding women.
• Kidney or Liver Disease: Inform your doctor if you have kidney or liver problems, as dosage adjustments or monitoring may be necessary. It is contraindicated in patients with severe liver disease.
• Blood Pressure: NEPTAZ 200 MG TABLET can cause low blood pressure. Patients should get up slowly and carefully to reduce the risk of orthostatic hypotension (sudden lowering of blood pressure when standing).
• Drug Interactions:
  • Avoid taking with ACE inhibitors (e.g., captopril, enalapril) due to an increased risk of serious side effects like angioedema. A gap of at least 36 hours is required before or after taking an ACE inhibitor.
  • Do not use if you have diabetes or impaired kidney function and are being treated with aliskiren.
  • Avoid potassium-containing salt substitutes or over-the-counter potassium supplements unless advised by your doctor, as this can lead to high potassium levels.
  • Inform your doctor about all other medications you are taking, including lithium and other heart or blood pressure medications.
• Alcohol Consumption: Avoid alcohol while taking this medicine as it may interact and lead to adverse effects.
• Use in Children: Not advised for children under one year of age; use with caution in children above one year.
• Use in Elderly: Use with caution in patients 65 years of age and above.
• Driving and Operating Machinery: This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery if you experience these side effects.
• Diabetes: If you have diabetes, consult your doctor before taking this medicine, as it may induce hypoglycemia.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep out of the sight and reach of children.
• Store at temperatures between 10ºC to 25ºC or below 30ºC.
• Store in the original package to protect from light.

NEPTAZ 200 MG TABLET (7 TAB) by MANKIND PHARMA LTD. - Frequently Asked Questions

What is NEPTAZ 200 MG TABLET used for?

NEPTAZ 200 MG TABLET is primarily used to treat heart failure in adults with long-term (chronic) heart failure, especially those with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization associated with heart failure. Symptoms of heart failure can include difficulty breathing, fatigue, and swelling in the ankles.

How does NEPTAZ 200 MG TABLET work?

NEPTAZ 200 MG TABLET is a combination medicine containing sacubitril and valsartan, which belong to a class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs). Sacubitril works by increasing the levels of certain beneficial peptides in the body that relax blood vessels, promote sodium excretion through urine, and increase urination, thereby lowering blood pressure. Valsartan works by blocking the effects of a hormone called angiotensin II, which normally constricts blood vessels. By blocking angiotensin II, valsartan helps relax and widen blood vessels, making it easier for the heart to pump blood throughout the body. Together, these actions improve heart function and reduce the strain on the heart.

What is the usual dosage for NEPTAZ 200 MG TABLET?

The dosage of NEPTAZ 200 MG TABLET is determined by your doctor based on your condition and how well you respond to the medicine. It should be taken as instructed by your doctor, usually at the same time each day, with or without food. The tablets should be swallowed whole with water and not chewed, crushed, or broken. It is crucial to continue taking the medication regularly as prescribed, even if you start to feel better, and not to stop suddenly, as this may worsen your condition.

What are the possible side effects of NEPTAZ 200 MG TABLET?

Common side effects of NEPTAZ 200 MG TABLET can include dizziness, light-headedness (due to low blood pressure), cough, nausea, diarrhea, headache, fatigue or weakness, and increased potassium levels in the blood (hyperkalemia). Some rare but serious side effects include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat, which can cause breathing difficulties) and impaired kidney function. If you experience severe or persistent side effects, contact your doctor immediately.

Is NEPTAZ 200 MG TABLET safe during pregnancy or breastfeeding?

NEPTAZ 200 MG TABLET is not recommended during early pregnancy and must not be used after the first three months of pregnancy as it can cause serious harm to the unborn baby. It is also not recommended for use in breastfeeding women, as the drug may pass into breast milk and potentially harm the baby. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor.

Can NEPTAZ 200 MG TABLET be taken with other medications?

It is crucial to inform your doctor about all other medications, herbal preparations, and supplements you are currently taking to avoid potential drug interactions. NEPTAZ 200 MG TABLET should not be taken with ACE inhibitors (e.g., enalapril, lisinopril, ramipril); you should wait at least 36 hours after taking the last dose of an ACE inhibitor before starting NEPTAZ. Concomitant use with aliskiren (a blood pressure-lowering medicine) is also contraindicated if you have diabetes or kidney disease. Other medications that can interact include potassium supplements, potassium-containing salt substitutes, certain diuretics, NSAIDs (painkillers), and sildenafil.

What precautions should be taken with NEPTAZ 200 MG TABLET?

Inform your doctor if you have kidney or liver problems, a history of angioedema, low blood pressure, or are dehydrated. Regular monitoring of blood pressure and kidney function is often advised during treatment. Avoid driving or operating heavy machinery if you experience dizziness or tiredness after taking this medicine. Alcohol consumption should also be avoided as it can cause dizziness.

What happens if a dose of NEPTAZ 200 MG TABLET is missed?

If you miss a dose of NEPTAZ 200 MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should NEPTAZ 200 MG TABLET be stored?

NEPTAZ 200 MG TABLET should be stored at room temperature, away from light and moisture. Keep it out of the sight and reach of children. Do not store above 25°C.