Exermet Sr 500 Tablet

EXERMET SR 500 TABLET

Name: EXERMET SR 500 TABLET (Brand names include Exermet 500 SR Tablet, Exermet Sr Tablet). Manufactured by Cipla Ltd..

Composition: Each tablet contains Metformin Hydrochloride 500 mg. It is a sustained-release (SR) formulation, designed for gradual release of the medication.

Uses:

• Type 2 Diabetes Mellitus: EXERMET SR 500 TABLET is prescribed to manage and control blood sugar levels in adults with type 2 diabetes, especially when diet and exercise alone are insufficient. It works by decreasing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin.
• Polycystic Ovary Syndrome (PCOS): It is also used to treat PCOS in women, helping to improve insulin sensitivity, regulate menstrual cycles, reduce symptoms like excess hair growth and acne, and support weight management.

Dosage and Administration:

• EXERMET SR 500 TABLET should be taken orally, typically once or twice daily, with meals to minimize gastrointestinal side effects.
• The usual starting dose is 500 mg once daily, often with the evening meal. Your doctor may gradually increase the dosage based on blood sugar levels and tolerance, up to a maximum of 2000 mg per day, which may be divided into two or three doses.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect its sustained-release properties.
• Take the medicine regularly, ideally at the same time each day, for optimal benefits. Do not stop taking it without consulting your doctor.

Side Effects:

• Common: Diarrhea, nausea, vomiting, flatulence, abdominal discomfort, headache, indigestion, metallic taste, and loss of appetite. These side effects are often temporary and can be reduced by taking the medicine with food.
• Serious: Lactic acidosis (a rare but serious condition that requires immediate medical attention), and prolonged use may lead to Vitamin B12 deficiency.

Precautions:

• Inform your doctor about any pre-existing kidney, liver, or heart problems. EXERMET SR 500 TABLET is generally not recommended for patients with severe kidney disease or severe liver disease.
• Avoid excessive alcohol consumption while taking this medicine, as it can increase the risk of lactic acidosis and hypoglycemia (low blood sugar).
• Use with caution in pregnant or breastfeeding women; consult your healthcare provider.
• Regular monitoring of blood sugar levels and kidney function is essential during treatment.
• Interactions can occur with other medicines, including insulin, sulfonylureas (e.g., glimepiride), diuretics (e.g., furosemide), and certain pain/swelling reducers (e.g., Ibuprofen, Celecoxib).

Storage:

• Store EXERMET SR 500 TABLET in a cool, dry place, typically at room temperature between 20°C and 25°C, or below 30°C.
• Protect from direct sunlight and high humidity.
• Keep out of sight and reach of children.

What is EXERMET SR 500 TABLET used for?

EXERMET SR 500 TABLET is primarily used to manage and control blood sugar levels in adults with type 2 diabetes mellitus, especially in overweight patients where diet and exercise alone haven't been sufficient. It is also used to treat Polycystic Ovary Syndrome (PCOS) in women, helping to improve insulin sensitivity, regulate menstrual cycles, and reduce symptoms like excess hair growth and acne. Additionally, it can help prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, and may reduce the risk of heart attack or stroke.

How does EXERMET SR 500 TABLET work?

EXERMET SR 500 TABLET contains Metformin, a biguanide. It works through several mechanisms to lower blood sugar levels. Firstly, it decreases glucose production in the liver. Secondly, it increases the body's sensitivity to insulin in peripheral tissues like muscle and fat, allowing cells to use glucose more effectively. Thirdly, it reduces the absorption of glucose from the intestines. This multi-pronged approach helps to maintain stable blood sugar control. For PCOS, it improves insulin sensitivity, which helps to lower insulin and androgen levels, restoring hormonal balance and menstrual regularity.

What is the usual dosage of EXERMET SR 500 TABLET?

EXERMET SR 500 TABLET is for oral administration and should be taken exactly as prescribed by your doctor. The typical starting dose is usually one tablet (500 mg) once daily, often taken with the evening meal to minimize gastrointestinal side effects. Your doctor may gradually increase the dosage in increments of 500 mg every 10-15 days or weekly, up to a maximum of 2000 mg (4 tablets) per day, depending on your blood sugar levels and tolerance. The maximum daily dose is usually divided and taken two to three times a day with meals. It's important to swallow the tablet whole with a full glass of water and not crush, chew, or break it, as this can affect its sustained-release properties.

What are the possible side effects of EXERMET SR 500 TABLET?

Common side effects of EXERMET SR 500 TABLET include gastrointestinal issues such as diarrhea, nausea, vomiting, abdominal pain or discomfort, flatulence, headache, and loss of appetite. These side effects are usually mild and temporary. Prolonged use may lead to Vitamin B12 deficiency. In rare cases, a serious side effect called lactic acidosis can occur, which requires immediate medical attention. Symptoms of lactic acidosis include weakness, muscle pain, trouble breathing, stomach pain with nausea and vomiting, dizziness, or lightheadedness.

Is EXERMET SR 500 TABLET safe during pregnancy or breastfeeding?

EXERMET SR 500 TABLET should be used with caution during pregnancy and only if prescribed by your doctor. While animal studies have shown low or no adverse effects, human studies are limited. For breastfeeding, Metformin is known to pass into breast milk in small amounts. It should be used with caution, and only if prescribed by your doctor. Your doctor will weigh the benefits and risks.

Can EXERMET SR 500 TABLET be taken with other medications?

It's crucial to inform your doctor about all other medications, supplements, and herbal products you are taking before starting EXERMET SR 500 TABLET. Certain medications can interact, potentially affecting its effectiveness or increasing the risk of side effects. For example:

• Insulin and Sulfonylureas: These can intensify the blood sugar-lowering effect, increasing the risk of hypoglycemia (low blood sugar).
• Diuretics: These can lead to dehydration and electrolyte imbalance, potentially increasing the risk of lactic acidosis.
• Corticosteroids: These can increase blood sugar levels, reducing the effectiveness of EXERMET SR 500 TABLET.
• Cationic Medications (e.g., amiloride, digoxin, morphine): These may increase the accumulation of both medicines.
• Carbonic Anhydrase Inhibitors (e.g., acetazolamide): Can cause metabolic acidosis and increase the risk of lactic acidosis.
• Iodinated Contrast Agents: These can lead to acute renal failure and metformin accumulation, increasing the risk of lactic acidosis.

What precautions should be taken with EXERMET SR 500 TABLET?

Before taking EXERMET SR 500 TABLET, inform your doctor about any existing medical conditions, especially kidney or liver problems, heart failure, or a history of lactic acidosis. Regular monitoring of blood sugar levels and kidney function is essential during treatment. Avoid excessive alcohol consumption, as it can lower blood sugar and increase the risk of lactic acidosis. If you experience continuous diarrhea, vomiting, or loss of body fluids, contact your doctor. Be cautious if you experience signs of low blood glucose, such as dizziness or weakness, especially if driving.

What happens if a dose of EXERMET SR 500 TABLET is missed?

If you miss a dose of EXERMET SR 500 TABLET, take it as soon as you remember, ideally with food. However, if it's almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

How should EXERMET SR 500 TABLET be stored?

EXERMET SR 500 TABLET should be stored in a cool, dry place, typically between 20°C and 25°C, protected from direct sunlight and high humidity. Keep it out of reach and sight of children. Always check the expiry date on the pack before taking the medicine.