Afoglip M 500 Mg Tablet (15 Tab)

AFOGLIP M 500 MG Tablet is a combination medication prescribed for the management of type 2 diabetes mellitus. It helps control high blood sugar levels in adults when diet and exercise alone are insufficient.

Name

• Brand Name: AFOGLIP M 500 MG TABLET
• Manufacturer: Torrent Pharmaceuticals Ltd.

Composition

Each tablet contains two active ingredients:

• Metformin (500 mg)
• Teneligliptin (20 mg)

Uses

AFOGLIP M 500 MG Tablet is primarily used for:

• Treating type 2 diabetes mellitus in adults
• Improving glycemic control by reducing liver glucose production, lowering intestinal glucose uptake, and increasing insulin levels
• As an adjunct to a healthy diet and regular physical activity for effective diabetes management

Dosage and Administration

• Typically taken once daily, or as advised by a physician.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It is recommended to take the tablet with food to reduce stomach upset.

Side Effects

Common Side Effects:

• Nausea, vomiting
• Diarrhea, stomach ache
• Headache
• Respiratory infection
• Weight gain, sweating

Serious Side Effects:

• Lactic Acidosis: A rare but serious condition, indicated by symptoms such as abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. This requires immediate medical attention.
• Hypoglycemia (low blood sugar), especially when combined with other diabetes medications like insulin or sulfonylureas.

Precautions

• Inform your doctor if you have liver, kidney, or heart problems, severe infection, or a history of pancreatitis.
• Avoid excessive alcohol consumption as it increases the risk of lactic acidosis.
• Caution is advised if pregnant or breastfeeding; consult your doctor.
• Long-term use may lead to Vitamin B12 deficiency; monitoring may be advised.
• Do not stop taking this medicine abruptly.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep out of the sight and reach of children and pets.
• Store below 25°C or at room temperature.

Frequently Asked Questions about AFOGLIP M 500 MG TABLET

AFOGLIP M 500 MG TABLET is a medication commonly prescribed for managing type 2 diabetes mellitus. It contains two active ingredients, Metformin and Teneligliptin, which work together to help control blood sugar levels.

What is AFOGLIP M 500 MG TABLET used for?

AFOGLIP M 500 MG TABLET is used to improve blood sugar control in adults with type 2 diabetes mellitus. It is typically prescribed alongside a proper diet and exercise regimen. This medication helps manage high baseline HbA1c levels and can be used as a second-line treatment when blood sugar levels are not adequately controlled by metformin alone.

How does AFOGLIP M 500 MG TABLET work?

AFOGLIP M 500 MG TABLET contains Metformin and Teneligliptin. Metformin, a biguanide, works by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and enhancing insulin sensitivity in peripheral tissues, thereby lowering blood sugar levels. Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by slowing the breakdown of incretin hormones (GLP-1 and GIP), which increases insulin release from the pancreas and decreases hormones that raise blood sugar levels, especially after meals.

What is the usual dosage for AFOGLIP M 500 MG TABLET?

AFOGLIP M 500 MG TABLET is typically taken orally, usually once daily with the evening meal. The tablet should be swallowed whole with water and should not be crushed, chewed, or broken. It is crucial to follow your doctor's prescribed dosage and duration, as it depends on individual conditions and blood sugar levels.

What are the possible side effects of AFOGLIP M 500 MG TABLET?

Common side effects of AFOGLIP M 500 MG TABLET may include upper respiratory tract infection, diarrhea, headache, hypertension, nausea, vomiting, and flatulence. Some patients might also experience stomach upset or low blood sugar (hypoglycemia), especially if taken with other diabetes medications like insulin. A rare but serious side effect associated with Metformin is lactic acidosis, characterized by symptoms like muscle pain, difficulty breathing, persistent nausea, vomiting, and stomach pain, which requires immediate medical attention.

Is AFOGLIP M 500 MG TABLET safe during pregnancy or breastfeeding?

Caution is advised when taking AFOGLIP M 500 MG TABLET during pregnancy, and it may be considered unsafe. For breastfeeding women, limited data exists, and it is generally considered probably unsafe or not recommended, as components may pass into breast milk and potentially harm the infant. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can AFOGLIP M 500 MG TABLET be taken with other medications?

AFOGLIP M 500 MG TABLET can interact with various medications. For instance, carbonic anhydrase inhibitors (e.g., acetazolamide) and cationic medications (e.g., amiloride, digoxin) may increase the risk of lactic acidosis or metformin accumulation. CYP3A4/P-gp inducers (e.g., rifampin) may reduce the effectiveness of teneligliptin. Other antidiabetic medicines, steroids, and certain blood pressure medications can also interact. Always inform your doctor about all medicines, including over-the-counter drugs and herbal supplements, you are currently taking.

What precautions should be taken with AFOGLIP M 500 MG TABLET?

Before taking this medicine, inform your doctor if you have kidney, liver, or heart disease, problems with your pancreas, or a history of metabolic acidosis or severe infection. Excessive alcohol consumption should be avoided as it increases the risk of lactic acidosis. Regular monitoring of kidney function and blood sugar levels is important during treatment. AFOGLIP M 500 MG TABLET may also lead to Vitamin B12 deficiency with long-term use.

What happens if a dose is missed?

If you miss a dose of AFOGLIP M 500 MG TABLET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one without consulting your doctor. Missing doses frequently can lead to high blood sugar and increase the risk of diabetes complications.

How should AFOGLIP M 500 MG TABLET be stored?

AFOGLIP M 500 MG TABLET should be stored in a cool and dry place, ideally below 25°C or 30°C, away from direct sunlight and moisture. Keep the medicine in its original container, tightly closed, and out of reach of children and pets. Dispose of any unused medicine according to instructions.