Doxinate Plus Tablet (30 Tab)

DOXINATE PLUS TABLET is a combination medication manufactured by Maneesh Pharmaceuticals Ltd., primarily used to manage nausea and vomiting during pregnancy, often referred to as morning sickness. It also provides essential nutrients beneficial for both maternal and fetal health.

Name

• Brand Name: DOXINATE PLUS TABLET
• Manufacturer: Maneesh Pharmaceuticals Ltd.

Composition Each tablet contains:

• Doxylamine: 10 mg
• Pyridoxine (Vitamin B6): 10 mg
• Folic Acid: 2.5 mg

Uses DOXINATE PLUS TABLET is prescribed for the treatment of:

• Nausea and vomiting during pregnancy (morning sickness).
• Supplementing essential nutrients for fetal development and maternal well-being.

Dosage and Administration

• Take DOXINATE PLUS TABLET exactly as prescribed by a healthcare professional.
• It is typically administered orally.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it due to its special delayed-release coating.
• It can be taken on an empty stomach or as advised by your doctor.
• Do not discontinue the medicine abruptly, as symptoms may return.

Side Effects Common side effects may include:

• Drowsiness/Sleepiness
• Dizziness/Lightheadedness
• Dry mouth
• Tiredness/Fatigue
• Constipation Consult your doctor if any side effects persist or worsen.

Precautions

• Inform your doctor about any existing medical conditions, especially asthma, glaucoma, stomach ulcers, blockages in the gastrointestinal or urinary tract, or vitamin B12 deficiency.
• Not recommended for use in children below 18 years of age.
• Use with caution during breastfeeding, as components may pass into breast milk.
• Avoid alcohol consumption while on this medication, as it may increase drowsiness and other side effects.
• Due to potential dizziness and drowsiness, avoid driving or operating heavy machinery until you know how the medicine affects you.
• Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, to prevent potential interactions, especially with MAO inhibitors, sleeping pills, pain killers, and cough/cold medicines.

Storage

• Store DOXINATE PLUS TABLET below 25°C or 30°C.
• Keep in a clean, dry place, protected from moisture, direct sunlight, and heat.
• Keep out of sight and reach of children and pets.

DOXINATE PLUS TABLET is a medication primarily used to manage nausea and vomiting during pregnancy, commonly known as morning sickness. It is a combination medicine containing doxylamine, pyridoxine (Vitamin B6), and folic acid.

What is DOXINATE PLUS TABLET used for?

DOXINATE PLUS TABLET is prescribed to treat nausea and vomiting experienced during pregnancy. It helps alleviate these symptoms, which are often caused by hormonal changes, and also provides essential nutrients like folic acid and vitamin B6 crucial for the healthy development of the fetus.

How does DOXINATE PLUS TABLET work?

The tablet contains three active ingredients: Doxylamine, Pyridoxine (Vitamin B6), and Folic Acid. Doxylamine is an antihistamine that works by blocking certain natural chemicals, like histamine, in the body that trigger nausea and vomiting. Pyridoxine helps by restoring vitamin B6 levels, as a deficiency can contribute to morning sickness, and it also has anti-nausea properties. Folic acid is a B vitamin that supplies vital nutrients for healthy fetal development.

What is the usual dosage for DOXINATE PLUS TABLET?

The dosage of DOXINATE PLUS TABLET should be strictly as prescribed by your doctor. It is typically taken on an empty stomach and swallowed whole with a glass of water, without chewing, crushing, or breaking the tablet. Your doctor will determine the correct dose and duration based on your symptoms and condition. Often, it is prescribed at bedtime, and depending on the severity of symptoms, the dosage may vary from once to twice daily.

What are the possible side effects of DOXINATE PLUS TABLET?

Common side effects may include drowsiness, dizziness, dry mouth, tiredness, constipation, weakness, and stomach pain. These side effects are generally mild and temporary, resolving as your body adjusts to the medication. If any side effects persist or worsen, it is important to inform your doctor immediately.

Is DOXINATE PLUS TABLET safe during pregnancy or breastfeeding?

DOXINATE PLUS TABLET is considered safe for use during pregnancy when prescribed by a doctor, as it is specifically designed to manage nausea and vomiting in pregnant women.

However, caution is advised during breastfeeding. Doxylamine, one of the components, can pass into breast milk and may cause sedation and irritability in nursing infants. Therefore, it is generally not recommended for breastfeeding mothers, or your doctor may advise you to stop breastfeeding while on this medication.

Can DOXINATE PLUS TABLET be taken with other medications?

DOXINATE PLUS TABLET can interact with other medicines. It is important to inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal remedies, and supplements, to avoid potential interactions.

Avoid taking it with:

• Monoamine Oxidase Inhibitors (MAOIs) (certain antidepressants) as they can increase and prolong the effects of Doxinate Plus on your central nervous system.
• Central Nervous System (CNS) depressants like sleeping pills (e.g., zolpidem, alprazolam), opioid pain relievers (e.g., morphine), and some cough or cold medicines, as this combination can lead to excessive drowsiness and dizziness.
• Anticholinergic medicines (e.g., atropine) as they can worsen side effects like dry mouth, blurred vision, or increased heart rate. Additionally, pyridoxine in Doxinate Plus can reduce the effects of certain medicines like Levodopa, Phenobarb, and Phenytoin.

What precautions should be taken while using DOXINATE PLUS TABLET?

• Alcohol: Do not consume alcohol while taking this medicine, as it can significantly increase drowsiness and dizziness.
• Driving/Operating Machinery: Due to potential drowsiness and dizziness, avoid driving or operating heavy machinery until you know how the medicine affects you.
• Medical Conditions: Inform your doctor if you have pre-existing conditions such as asthma, glaucoma (increased eye pressure), stomach ulcer, blockages in the stomach, small intestine, or bladder, or vitamin B12 deficiency.
• Children: This medicine is not recommended for use in children below 18 years of age.
• Abrupt Discontinuation: Do not stop taking the medicine suddenly, as this may lead to the recurrence or worsening of your symptoms.

What happens if a dose of DOXINATE PLUS TABLET is missed?

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.

How should DOXINATE PLUS TABLET be stored?

Store DOXINATE PLUS TABLET at a cool room temperature, ideally between 20°C and 25°C, or below 25°C/30°C. Keep the tablets in their original packaging in a dry place, protected from moisture, direct sunlight, and heat. Always ensure the medicine is kept out of the sight and reach of children and pets. Check the expiry date before use.