Nucoxia Pg Tablet (10 Tab)

NUCOXIA PG TABLET is a combination medicine manufactured by Zydus Cadila, designed to provide relief from neuropathic pain and inflammatory conditions.

Name

• Brand Name: NUCOXIA PG TABLET (10 TAB)
• Manufacturer: CADILA (ZYDUS)
• Common Name: Etoricoxib and Pregabalin Tablet

Composition

NUCOXIA PG TABLET contains two active ingredients:

• Etoricoxib (60 mg): A non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins responsible for pain and inflammation.
• Pregabalin (75 mg): An anticonvulsant and analgesic that works by modulating calcium channels in the central nervous system, reducing the release of neurotransmitters that transmit pain signals.

Uses

NUCOXIA PG TABLET is primarily used for the management of neuropathic pain and pain associated with inflammatory conditions.

• Neuropathic Pain: Including diabetic neuropathy, post-herpetic neuralgia (pain after shingles), neuropathic pain associated with spinal cord injury, fibromyalgia, trigeminal neuralgia, and central neuropathic pain.
• Inflammatory Pain: Such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gout. It also provides relief from muscle pain, back pain, toothache, post-operative pain, ear pain, throat pain, period pain, bone and joint pain, and spondylitis.

Dosage and Administration

• Take NUCOXIA PG TABLET exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• It can be taken with or without food, though taking it after food may help reduce the risk of stomach upset.
• For best results, take the medicine at the same time each day to maintain consistent medication levels.
• The dosage and duration of treatment will be determined by your doctor based on your condition and response to the medication. Do not exceed the prescribed dose.

Side Effects

Common side effects may include:

• Dizziness, drowsiness/sleepiness, headache
• Nausea, vomiting, stomach pain/upset, constipation, diarrhoea, flatulence
• Dry mouth, increased appetite, weight gain
• Swelling of ankles or feet (peripheral oedema)
• Blurred vision, difficulty concentrating, fatigue
• Cold and flu symptoms, irregular heartbeat

Serious side effects requiring immediate medical attention include breathing difficulties, chest pain, ankle swelling, liver issues, severe stomach pain, black stools, or signs of allergic reactions (e.g., skin ulcers, blistering, facial swelling that affects breathing).

Precautions

• Allergies: Do not take if you are allergic to etoricoxib, pregabalin, other NSAIDs (such as aspirin or celecoxib), or any other ingredients in the tablet.
• Pregnancy and Breastfeeding: NUCOXIA PG TABLET is generally not recommended during pregnancy, especially in the third trimester, or while breastfeeding, unless considered clearly necessary by a doctor.
• Alcohol: Avoid consuming alcohol, as it can intensify side effects like drowsiness and dizziness and increase the risk of liver damage.
• Driving and Machinery: This medicine may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating machinery until you understand how it affects you.
• Pre-existing Conditions: Use with caution or avoid if you have severe liver or kidney diseases, inflammatory bowel diseases, gastrointestinal bleeding, congestive heart failure, uncontrolled high blood pressure, or a history of cardiovascular or cerebrovascular disease.
• Drug Interactions: Inform your doctor about all other medications, supplements, or herbal products you are taking, as NUCOXIA PG TABLET can interact with various drugs including other painkillers, antiepileptic drugs, blood thinners, diuretics, and certain antidepressants.
• Children and Elderly: This medication is not recommended for use in children under a certain age. Elderly patients should use it with caution as they may be more susceptible to side effects.
• Monitoring: For long-term treatment, your doctor may recommend regular blood tests to monitor liver function.

Storage

• Store NUCOXIA PG TABLET at room temperature, ideally between 15-30°C or below 30°C.
• Keep the medicine in a cool, dry place, away from direct sunlight and moisture.
• Keep it out of reach of children and pets.
• Always check the expiry date on the packaging before use.

NUCOXIA PG TABLET is a combination medicine containing Etoricoxib and Pregabalin, used to manage various pain conditions, particularly neuropathic pain.

What is Nucoxia PG Tablet used for?

Nucoxia PG Tablet is primarily used to treat long-lasting (chronic) pain caused by nerve damage, known as neuropathic pain. This includes conditions such as diabetic peripheral neuropathy (nerve damage due to high sugar levels), post-herpetic neuralgia (pain after shingles infection), fibromyalgia (widespread muscle pain), and neuropathic pain associated with spinal cord injury. It may also be used for other painful conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, muscle pain, back pain, and post-operative pain.

How does Nucoxia PG Tablet work?

Nucoxia PG Tablet combines two active ingredients: Etoricoxib and Pregabalin.

• Etoricoxib is a selective COX-2 inhibitor, a type of non-steroidal anti-inflammatory drug (NSAID). It works by blocking the COX-2 enzyme, which is responsible for producing prostaglandins that cause pain and inflammation. This action reduces pain, inflammation, and swelling.
• Pregabalin is an anticonvulsant and pain modulator. It binds to specific sites on voltage-gated calcium channels in the nervous system, which helps to reduce the release of certain neurotransmitters that send pain signals. This calms overactive nerves, thereby decreasing the intensity of pain signals reaching the brain.

Together, these ingredients provide dual-action relief by addressing both nerve-related pain and inflammation.

What is the usual dosage of Nucoxia PG Tablet?

The dosage of Nucoxia PG Tablet is determined by your doctor based on your specific condition, its severity, and your response to treatment. It is crucial to take the tablet exactly as prescribed by your doctor and not to exceed the recommended dose. The tablet should be swallowed whole with a glass of water, and can be taken with or without food, preferably at the same time each day for consistent medication levels. Your doctor may start with a low dose and gradually increase it.

What are the possible side effects?

Common side effects of Nucoxia PG Tablet include dizziness, sleepiness/drowsiness, difficulty in concentrating, dry mouth, blurred vision, weight gain, swelling of hands or feet (peripheral edema), headache, nausea, vomiting, flatulence, constipation, diarrhea, and muscle pain. Most side effects are usually mild and temporary, often resolving as your body adjusts to the medication. If any side effects persist or worsen, consult your doctor. Serious side effects like breathing difficulties, chest pain, liver issues, severe stomach pain, or signs of allergic reactions (skin ulcers, blistering, facial swelling) require immediate medical attention.

Is Nucoxia PG Tablet safe during pregnancy or breastfeeding?

Nucoxia PG Tablet is generally not recommended during pregnancy, especially in the third trimester, due to a lack of safety data and potential risks. Women who are pregnant or planning to conceive should consult their doctor before taking this medicine.

It is also generally not recommended during breastfeeding, as the components may pass into human breast milk. Your doctor will assess the benefits and risks before recommending its use during lactation.

Can it be taken with other medications?

Inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential drug interactions. Nucoxia PG Tablet can interact with various medications, including:

• Medicines for fits/seizures: Phenytoin, carbamazepine, lamotrigine, valproic acid.
• Medicines for anxiety: Lorazepam.
• Pain relievers: Oxycodone, acetylsalicylic acid (aspirin), other NSAIDs (e.g., ibuprofen).
• Diuretics (water pills): Chlorothiazide, chlorthalidone, furosemide.
• Blood thinners/anticoagulants: Warfarin, clopidogrel, low-dose aspirin.
• Medicines for high blood pressure: Angiotensin II antagonists (e.g., telmisartan, losartan), ramipril.
• Immunosuppressants: Cyclosporin, tacrolimus.
• Other CNS depressants: Diazepam, fluoxetine, alcohol, as these can enhance side effects like drowsiness.
• Oral contraceptives: Ethinyl estradiol, norethindrone.

What precautions should be taken?

Several precautions should be taken:

• Medical supervision: Nucoxia PG Tablet should only be taken under medical supervision due to the potential for addiction, dependence, and withdrawal reactions.
• Underlying conditions: Inform your doctor if you have a history of heart disease (e.g., congestive heart failure, high blood pressure, stroke), kidney disease, liver disease, stomach ulcers, gastrointestinal bleeding, inflammatory bowel disease, or diabetes.
• Alcohol: Avoid alcohol consumption as it can increase dizziness and sleepiness, and may increase the risk of liver damage.
• Driving and operating machinery: This medicine can cause dizziness, drowsiness, and blurred vision. Avoid driving or operating heavy machinery until you know how it affects you.
• Children and adolescents: Not recommended for children and adolescents below 16 years of age.
• Vision changes: Inform your doctor immediately if you notice any changes in your vision.
• Long-term treatment: For long-term treatment, your doctor may recommend regular blood tests to monitor liver function.

What happens if a dose is missed?

If you miss a dose of Nucoxia PG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose (e.g., within 2 hours), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects. It is important to take this medicine regularly, especially if you have epilepsy, as missing doses can trigger a seizure.

How should it be stored?

Nucoxia PG Tablet should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it out of the reach of children.