Zoryl Mp 2 Mg Tablet (15 Tab)

ZORYL MP 2 MG TABLET by Intas Pharmaceuticals Ltd. is an oral antidiabetic medication used for the management of type 2 diabetes mellitus. It is typically prescribed when diet, exercise, and treatment with a single antidiabetic agent are not sufficient to control blood sugar levels.

Name

• Brand Name: ZORYL MP 2 MG TABLET (also known as Zoryl MP 2 Tablet ER)

Composition

Each tablet contains a combination of three active ingredients:

• Glimepiride: 2 mg
• Metformin: 500 mg
• Pioglitazone: 15 mg

These ingredients work together to enhance insulin sensitivity, decrease glucose production in the liver, delay glucose absorption from the intestines, and stimulate the pancreas to release more insulin, thereby lowering blood sugar levels.

Uses

ZORYL MP 2 MG TABLET is primarily used for:

• Treating type 2 diabetes mellitus in adults.
• Controlling high blood sugar levels when diet, exercise, and other single medications are inadequate.
• Reducing the risk of diabetes-related complications such as kidney damage, nerve problems, vision loss, and cardiovascular issues.

Dosage and Administration

• Take ZORYL MP 2 MG TABLET as directed by your doctor.
• It should be swallowed whole with a glass of water, preferably with food to minimize stomach upset.
• Take it at a fixed time daily for optimal results.
• Do not crush, cut, chew, or double the dose.
• If a dose is missed, take it as soon as you remember unless it is almost time for the next scheduled dose.

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Nausea, vomiting, diarrhea, abdominal pain, or stomach upset
• Headache, dizziness
• Metallic taste
• Muscle pain, joint pain, back pain
• Upper respiratory tract infection
• Edema (swelling due to fluid retention)
• Weight gain

Serious side effects, though rare, can include lactic acidosis (signs include unusual muscle pain, trouble breathing, cold hands/feet, weakness), and symptoms of heart failure (e.g., unusual shortness of breath, rapid weight gain, swelling). Seek immediate medical attention if these occur.

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy and breastfeeding as it may harm the unborn baby or be excreted in breast milk. Consult your doctor.
• Alcohol: Avoid alcohol consumption as it can increase the risk of lactic acidosis and hypoglycemia.
• Medical Conditions: Inform your doctor if you have kidney disease, liver problems, heart failure (especially Class III or IV), metabolic acidosis, or any severe infections.
• Driving and Using Machines: May cause low blood sugar, leading to drowsiness, confusion, or visual disturbances, which can affect driving ability.
• Interactions: Inform your doctor about all other medicines, including supplements and herbal products, to avoid potential drug interactions.

Storage

• Store below 30°C.
• Keep in a cool and dry place, away from direct sunlight.
• Keep out of reach and sight of children.

What is ZORYL MP 2 MG TABLET used for?

ZORYL MP 2 MG TABLET is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and treatment with a single or dual anti-diabetic medication are not sufficient to control blood sugar levels. This medicine helps to effectively lower high blood sugar and reduce the risk of diabetes-related complications such as kidney damage, nerve problems, vision loss, limb amputations, and cardiovascular diseases like heart attack and stroke.

How does ZORYL MP 2 MG TABLET work?

ZORYL MP 2 MG TABLET is a combination of three active ingredients: Glimepiride, Metformin, and Pioglitazone, each working through different mechanisms to control blood sugar.

• Glimepiride is a sulfonylurea that stimulates the pancreas to release more insulin, a hormone that helps move sugar (glucose) from the blood into cells.
• Metformin is a biguanide that reduces glucose production in the liver, delays the absorption of glucose from the intestines, and increases the body's sensitivity to insulin.
• Pioglitazone is a thiazolidinedione that enhances the body's response to insulin, particularly in muscle, fat, and liver tissues, allowing cells to utilize blood glucose more effectively.

What is the usual dosage for ZORYL MP 2 MG TABLET?

ZORYL MP 2 MG TABLET should be taken exactly as prescribed by your doctor. It is typically taken once daily with food to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken. The dosage is determined by your doctor based on your blood sugar levels and response to treatment.

What are the possible side effects of ZORYL MP 2 MG TABLET?

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Nausea, vomiting, diarrhea, or abdominal pain
• Loss of appetite or metallic taste
• Headache and muscle pain
• Fractures or upper respiratory tract infection
• Edema (swelling due to fluid retention)

In rare cases, more serious side effects like lactic acidosis (a buildup of lactic acid in the body) or symptoms of heart failure can occur. If you experience any severe or persistent side effects, contact your doctor immediately.

Is ZORYL MP 2 MG TABLET safe during pregnancy or breastfeeding?

ZORYL MP 2 MG TABLET is generally not recommended for use during pregnancy as it may harm the unborn baby. If you are pregnant or planning a pregnancy, your doctor may suggest alternative treatments.

Similarly, it is not recommended during breastfeeding because it is not known if the medicine passes into human milk and if it can harm the newborn baby. Always inform your doctor if you are a nursing mother.

Can ZORYL MP 2 MG TABLET be taken with other medications?

ZORYL MP 2 MG TABLET can interact with several other medications. It is crucial to inform your doctor about all the medicines, supplements, or herbal products you are currently taking or might take to avoid potential interactions. Some medications that may interact include:

• Other anti-diabetic medicines (e.g., insulin, glipizide)
• Certain heart or blood pressure medications
• Antibiotics (e.g., rifampicin, tetracycline, clarithromycin)
• Painkillers
• Blood thinners
• Antacids
• Carbonic anhydrase inhibitors (e.g., topiramate, zonisamide)
• Thiazide diuretics or corticosteroids

What precautions should be taken while on ZORYL MP 2 MG TABLET?

• Avoid consuming alcohol excessively while taking this medicine, as it can increase the risk of low blood sugar (hypoglycemia) and a serious condition called lactic acidosis.
• Regularly monitor your blood sugar levels as advised by your doctor.
• If you experience symptoms of low blood sugar (e.g., cold sweats, tremor, anxiety, confusion, dizziness), immediately consume a sugary food item or juice.
• Be cautious when driving or operating machinery, as ZORYL MP 2 MG TABLET can cause low blood sugar, leading to dizziness, drowsiness, or visual disturbances.
• Inform your doctor if you have kidney, liver, or heart problems, class III or IV heart failure, or any metabolic acidosis.
• Your doctor may conduct regular liver function tests during treatment.
• Protect your skin from the sun as this medication may increase sun sensitivity.

What happens if a dose of ZORYL MP 2 MG TABLET is missed?

If you miss a dose of ZORYL MP 2 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to dangerously low blood sugar levels. Missing a dose can result in elevated blood sugar levels.

How should ZORYL MP 2 MG TABLET be stored?

Store ZORYL MP 2 MG TABLET at room temperature in a cool and dry place. Protect it from light and moisture. Keep the medicine out of the reach of children and pets.