Pramirol 0.25 Mg Tablet (10 Tab)

PRAMIROL 0.25 MG TABLET

Pramirol 0.25 mg Tablet is a medication manufactured by Intas Pharmaceuticals Ltd., primarily used in the management of Parkinson's disease and Restless Legs Syndrome.

• Name

  • Brand Name: Pramirol 0.25 mg Tablet
  • Common Name (Active Ingredient): Pramipexole

• Composition

  • Each tablet contains Pramipexole 0.25 mg.

• Uses Pramirol 0.25 mg Tablet is prescribed for:

  • Parkinson's Disease: To manage symptoms such as tremors, stiffness, slow movement, and unsteadiness, by improving motor function.
  • Restless Legs Syndrome (RLS): For moderate-to-severe primary restless legs syndrome, reducing uncomfortable sensations and the irresistible urge to move the legs, particularly in the evening and at night.

• Dosage and Administration

  • Take Pramirol 0.25 mg Tablet exactly as directed by your doctor.
  • Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
  • It can be taken with or without food, though taking it with food may help reduce nausea.
  • For Restless Legs Syndrome, it is often advised to take the medicine 2 to 3 hours before bedtime.
  • It is crucial not to stop the medication suddenly without consulting your doctor.

• Side Effects

  • Common Side Effects: Nausea, dizziness, drowsiness (sleepiness), insomnia, constipation, headache, dry mouth, fatigue, muscle spasms, and peripheral edema (leg swelling due to fluid overload).
  • Serious Side Effects (Seek medical attention if experienced): Hallucinations (seeing or hearing things that are not real), sudden sleep attacks, dyskinesia (abnormal, uncontrolled movements), confusion, aggressive behavior, agitation, abnormal thoughts, changes in vision, and intense urges such as increased sex drive or compulsive gambling.

• Precautions

  • Kidney/Liver Impairment: Use with caution; dose adjustments may be necessary.
  • Cardiac Conditions: Use with caution in patients with heart conditions due to the risk of orthostatic hypotension (a sudden drop in blood pressure upon standing).
  • Psychiatric Disorders: Use cautiously in patients with a history of hallucinations or psychosis, as Pramirol may exacerbate these symptoms.
  • Pregnancy and Breastfeeding: Consult your doctor. Pramirol 0.25 mg Tablet is generally not recommended during breastfeeding as it can pass into breast milk and may reduce milk production.
  • Alcohol: Avoid or limit alcohol consumption, as it can increase drowsiness and dizziness.
  • Driving and Operating Machinery: This medicine may cause dizziness, drowsiness, or sudden sleep attacks. Avoid activities requiring alertness until you know how it affects you.
  • Drug Interactions: Inform your doctor about all other medications you are taking, especially sedatives, dopamine antagonists, and cimetidine, as interactions can occur.

• Storage

  • Store Pramirol 0.25 mg Tablets in a cool and dry place, below 30°C.
  • Protect from direct sunlight, moisture, and heat.
  • Keep out of the reach and sight of children.

PRAMIROL 0.25 MG TABLET, manufactured by Intas Pharmaceuticals Ltd., contains Pramipexole as its active ingredient. It is primarily used to manage the symptoms of Parkinson's disease and moderate-to-severe Restless Legs Syndrome (RLS).

What is PRAMIROL 0.25 MG TABLET used for?

PRAMIROL 0.25 MG TABLET is used to treat the symptoms of idiopathic Parkinson's disease, helping to improve motor function and reduce tremors, stiffness, slow movement, and unsteadiness. It is also effective in managing moderate-to-severe primary restless legs syndrome (RLS), which involves an uncomfortable sensation and an irresistible urge to move the legs, typically in the evenings or at night, thereby improving sleep quality.

How does PRAMIROL 0.25 MG TABLET work?

Pramirol 0.25 mg Tablet contains Pramipexole, which is a dopamine agonist. It works by mimicking the action of dopamine, a natural chemical messenger in the brain crucial for controlling body movements. In Parkinson's disease, dopamine levels are low, and Pramirol stimulates the dopamine receptors in the brain, thereby triggering nerve impulses that help control body movements. The exact mechanism for RLS is not fully understood, but it is also believed to involve stimulating dopamine receptors.

What is the usual dosage of PRAMIROL 0.25 MG TABLET?

The dosage of PRAMIROL 0.25 MG TABLET is determined by your doctor, depending on the severity of your condition and your response to the medicine. It is typically initiated at a low dose and gradually increased to avoid side effects. For Parkinson's disease, a common starting dose is 0.125 mg three times a day, which can be adjusted as needed, usually not exceeding 4.5 mg per day. For restless legs syndrome, the recommended starting dose is 0.125 mg once daily, taken 2 to 3 hours before bedtime. It should be swallowed whole with water, and not crushed, broken, or chewed. It can be taken with or without food.

What are the possible side effects of PRAMIROL 0.25 MG TABLET?

Common side effects of PRAMIROL 0.25 MG TABLET include nausea, dizziness, drowsiness, fatigue, constipation, dry mouth, headache, and insomnia. Some individuals may also experience hallucinations (seeing, hearing, or feeling things that are not present), orthostatic hypotension (a drop in blood pressure upon standing), and dyskinesia (uncontrolled body movements). More serious but less common side effects can include sudden sleep attacks and impulse control disorders (e.g., increased sex drive, compulsive gambling, overeating). If side effects persist or worsen, consult your doctor.

Is PRAMIROL 0.25 MG TABLET safe during pregnancy or breastfeeding?

PRAMIROL 0.25 MG TABLET is generally not recommended during pregnancy, and its safety in human pregnancy is limited. Your doctor will assess the benefits and risks before prescribing it during pregnancy. For breastfeeding women, PRAMIROL 0.25 MG TABLET is not recommended as it may reduce breast milk production, and it is unknown if Pramipexole passes into breast milk.

Can PRAMIROL 0.25 MG TABLET be taken with other medications?

PRAMIROL 0.25 MG TABLET can interact with other medicines. Caution is advised when taking it with sedatives, as this can increase drowsiness. Dopamine antagonists (like metoclopramide and certain antipsychotics) may reduce its effectiveness. If taken with levodopa for Parkinson's disease, your doctor may need to reduce the levodopa dose. Medicines affecting renal clearance, such as cimetidine, can increase the levels of Pramipexole in the body, requiring dose adjustment. Always inform your doctor about all medications, supplements, and herbal preparations you are taking.

What precautions should be taken?

PRAMIROL 0.25 MG TABLET should be used with caution in individuals with kidney conditions, low blood pressure, a history of mental health conditions (like hallucinations or psychosis), or cardiovascular disease. It can cause dizziness and drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Alcohol consumption should be avoided or limited as it can enhance side effects like sleepiness and dizziness. Rising slowly from a sitting or lying position can help prevent dizziness caused by orthostatic hypotension. Do not stop taking the medicine abruptly without consulting your doctor, as this can worsen symptoms or cause withdrawal effects.

What happens if a dose is missed?

If you miss a dose of PRAMIROL 0.25 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

PRAMIROL 0.25 MG TABLET should be stored in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of the reach and sight of children and pets.