Antidep 75 Tab

ANTIDEP 75 TAB by TORRENT PHARMACEUTICALS LTD

Name:

• Common Name: Imipramine
• Brand Name: Antidep 75 Tablet

Composition: Each Antidep 75 Tablet contains Imipramine Hydrochloride 75 mg. This medicine belongs to the tricyclic antidepressants (TCA) class of drugs.

Uses: Antidep 75 Tablet is primarily prescribed for the treatment of depression, including severe forms or when other antidepressant therapies have been ineffective. Additionally, it is used to manage bed-wetting (nocturnal enuresis) in children aged 6 years and older. It may also be used to treat chronic neuropathic pain.

Dosage and Administration: Antidep 75 Tablet should be taken orally, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole and not crushed, chewed, or broken. To minimize daytime drowsiness, the main dose is often recommended to be taken at night.

• For Depression in Adults: The typical initial dose ranges from 75 mg to 100 mg per day, which may be divided into multiple doses or taken once daily at bedtime. The dosage can be gradually adjusted by the doctor based on individual response and tolerance, usually not exceeding 300 mg per day in severely depressed patients.
• For Bed-wetting in Children (6 years and older): An initial dose of 25 mg is usually taken one hour before bedtime. If the response is unsatisfactory after one week, the dose may be increased, typically up to 50 mg for children under 12 years and up to 75 mg for children over 12 years. The daily dose should not exceed 2.5 mg/kg.
• For Elderly Patients: An initial dose of 10 mg at night may be prescribed, with gradual increases up to 30-50 mg daily, as dosages are often adjusted significantly for older adults.

Do not discontinue the medication suddenly; the dose should be gradually reduced under medical supervision to prevent withdrawal symptoms.

Side Effects: Common side effects include:

• Dry mouth
• Constipation
• Nausea, vomiting
• Drowsiness, sleepiness, unsteadiness, dizziness
• Blurred vision, changes in vision
• Increased heart rate, palpitations
• Difficulty in urination
• Orthostatic hypotension (sudden drop in blood pressure upon standing)
• Anxiety, nervousness
• Weight gain

Serious or less common side effects that require immediate medical attention include:

• Suicidal thoughts or attempts, worsening depression or anxiety
• Rashes or itching
• Hallucination, confusion, disorientation
• Irregular heartbeat, heart block, heart attack, stroke, heart failure
• Seizures
• Low body temperature
• Glaucoma (change in eye pressure)
• Sexual dysfunction
• Muscle stiffness, tremors

Precautions:

• Allergies: Do not take if allergic to imipramine or any of its components.
• Drug Interactions: Avoid concomitant use with monoamine oxidase inhibitors (MAOIs) or if MAOIs have been taken within the last 14 days, due to risk of serious adverse effects.
• Cardiac Conditions: Use with extreme caution in patients with heart disease, including heart failure, heart block, irregular heartbeats, or if recovering from a recent heart attack. Cardiac surveillance is required.
• Pregnancy and Breastfeeding: Not recommended during pregnancy as it can cause harmful effects to the unborn child, including breathing difficulties, irritability, and low blood pressure in newborns. It is also not recommended for breastfeeding women as it passes into breast milk.
• Driving and Operating Machinery: This medicine can cause drowsiness, sleepiness, and blurred vision, which may impair alertness. Avoid driving or operating heavy machinery until you are aware of how the medicine affects you.
• Alcohol Consumption: Avoid alcohol as it can increase the side effects of Antidep 75 Tablet, potentially leading to increased drowsiness, dizziness, hallucinations, convulsions, and breathing failure.
• Other Medical Conditions: Use with caution in patients with liver disease, kidney disease, glaucoma, seizure disorders, respiratory disease, paralytic conditions of the gut, chronic constipation, pheochromocytoma, neuroblastoma, schizophrenia, manic depression, enlarged prostate, overactive thyroid, low blood pressure, or if undergoing electroconvulsive therapy.
• Photosensitivity: May cause sensitivity to sunlight; use sunscreen or wear protective clothing.
• Children: Not recommended for children under 6 years of age.

Storage: Store Antidep 75 Tablet at room temperature, ideally between 20°C and 25°C (68°F and 77°F) or below 25°C/30°C. Keep it away from heat, moisture, and light. Due to its toxic effects, it should be stored out of reach of children and pets, preferably in a locked place, to prevent misuse.

Here are frequently asked questions about ANTIDEP 75 mg Tablet:

What is ANTIDEP 75 mg Tablet used for?

ANTIDEP 75 mg Tablet is primarily used to treat severe depression, especially when other medications have not been effective. It is also prescribed for bed-wetting (nocturnal enuresis) in children aged 6 years and older, and in some cases, for chronic neuropathic pain.

How does ANTIDEP 75 mg Tablet work?

ANTIDEP 75 mg Tablet contains imipramine, which belongs to a class of medicines called tricyclic antidepressants (TCAs). It works by increasing the levels of certain natural chemical messengers in the brain, such as serotonin and norepinephrine, which are responsible for regulating mood. This helps to alleviate symptoms of sadness, anxiety, and nervousness, thereby elevating mood. For bed-wetting, it helps control involuntary urination by relaxing the urinary bladder muscles.

What is the usual dosage for ANTIDEP 75 mg Tablet?

The dosage of ANTIDEP 75 mg Tablet varies depending on the condition being treated and the patient's age. For adults with depression, the usual starting dose is 75 mg to 100 mg per day, which can be taken in divided doses or once daily at bedtime. The dose may be adjusted by your doctor, typically not exceeding 300 mg per day. For children aged 6 years and above treating bed-wetting, an initial dose of 25 mg taken one hour before bedtime is common, which may be increased if needed, up to a maximum of 75 mg per night for children over 12 years. Always follow your doctor's specific instructions for dosage and duration. The tablet should be swallowed whole with or without food and not crushed or chewed.

What are the possible side effects of ANTIDEP 75 mg Tablet?

Common side effects of ANTIDEP 75 mg Tablet include drowsiness, sleepiness, dry mouth, constipation, blurred vision, increased heart rate, and difficulty urinating. Some individuals may also experience unsteadiness, delirium, anxiety, or weight gain. More serious, but rare, side effects can include rashes, dizziness, hallucinations, confusion, low blood pressure, irregular heartbeat, and suicidal thoughts. If you experience persistent or severe side effects, or any suicidal thoughts, contact your doctor immediately.

Is ANTIDEP 75 mg Tablet safe during pregnancy or breastfeeding?

ANTIDEP 75 mg Tablet is generally not recommended during pregnancy as it has been shown to cause harmful effects on the unborn child, such as breathlessness, irritability, tremors, and low blood pressure in infants. Similarly, it is probably unsafe during breastfeeding as the medicine is known to pass into breast milk and may lead to adverse effects in the newborn. It is crucial to discuss the potential risks and benefits with your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can ANTIDEP 75 mg Tablet be taken with other medications?

ANTIDEP 75 mg Tablet can interact with several other medications. It should not be taken with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of taking them, as this can lead to severe, life-threatening reactions. Combining it with alcohol is unsafe, as it can significantly increase drowsiness and other side effects. Caution is advised with other central nervous system depressants, SSRIs (selective serotonin reuptake inhibitors), and certain opioids, as these can increase the risk of side effects or lead to conditions like serotonin syndrome. Always inform your doctor about all prescription, over-the-counter, and herbal medications you are taking to avoid potential drug interactions.

What precautions should be taken while taking ANTIDEP 75 mg Tablet?

Several precautions should be observed when taking ANTIDEP 75 mg Tablet. It should be used with caution, or may be contraindicated, in individuals with heart conditions (including a history of heart attack, heart failure, or irregular heartbeat), liver or kidney disease, glaucoma, seizure disorders, schizophrenia, bipolar disorder, or an enlarged prostate. Due to potential drowsiness, blurred vision, and reduced alertness, avoid driving or operating heavy machinery until you know how the medicine affects you. Do not stop taking the medication suddenly, as this can lead to withdrawal symptoms; your doctor will advise on gradual discontinuation. Also, avoid excessive exposure to sunlight as it can cause photosensitivity.

What happens if a dose of ANTIDEP 75 mg Tablet is missed?

If you miss a dose of ANTIDEP 75 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ANTIDEP 75 mg Tablet be stored?

ANTIDEP 75 mg Tablet should be stored at room temperature, away from the reach of children and pets. It is advisable to keep it in a locked place to prevent misuse.